Older Age and Longer Epilepsy Duration Do Not Predict Worse
Seizure Reduction Outcome after Vagus Nerve Stimulation

J 2018

Older Age and Longer Epilepsy Duration Do Not Predict Worse Seizure Reduction Outcome after Vagus Nerve Stimulation

CHRASTINA, Jan, Jitka KOČVAROVÁ, Zdeněk NOVÁK, Irena DOLEŽALOVÁ, Michal SVOBODA et. al.

Základní údaje

Originální název

Older Age and Longer Epilepsy Duration Do Not Predict Worse Seizure Reduction Outcome after Vagus Nerve Stimulation

Autoři

CHRASTINA, Jan (203 Česká republika, garant, domácí), Jitka KOČVAROVÁ (203 Česká republika, domácí), Zdeněk NOVÁK (203 Česká republika, domácí), Irena DOLEŽALOVÁ (203 Česká republika, domácí), Michal SVOBODA (203 Česká republika, domácí) a Milan BRÁZDIL (203 Česká republika, domácí)

Vydání

Journal of Neurological Surgery, Part A: Central European Neurosurgery, New York, Thieme Medical Publ Inc, 2018, 2193-6315

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.060

Kód RIV

RIV/00216224:14110/18:00104102

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1055/s-0037-1607396

UT WoS

000426299500008

Klíčová slova anglicky

epilepsy; vagus nerve stimulation; seizures reduction; responder

Štítky

14110127, 14110131, 14119612, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2019 13:21, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Introduction We analyzed the results of vagus nerve stimulation (VNS) on older patients and patients with long-lasting epilepsy and included severely intellectually disabled patients. Patients and Methods A total of 103 adults with VNS implanted from 2005 to 2014 were studied. The responder rates, that is, the percentage of VNS patients who responded to VNS, classified as seizure reduction50% (50R) and seizure reduction90% (90R), were compared in defined age groups (< 40 and40 years, and<50 and50 years) and epilepsy duration groups (< 20 and20 years,<30 and30 years, and<40 and40 years) at the 1-year follow-up visit and the last follow-up visit (at least 2 years after surgery). The age distributions and responder rates were also studied in patients with an intellectual disability. Results The analysis did not confirm a significantly lower 50R or 90R rate in patients40,50, or60 years when compared with their younger counterparts, but the 50R rate increase during follow-up care was the lowest in patients50 and60 years. The highest percentage of patients with an intellectual disability in the group<40 years of age did not adversely affect the 50R rate. Longer epilepsy duration was not confirmed as a negative predictor of VNS outcome. There was a significantly higher 50R rate in patients with epilepsy duration20 years (at the last follow-up visit) and a higher 90R rate in patients with epilepsy duration30 years (at the 1-year follow-up visit). The increase in the 50R rate during follow-up care was lower in patients with epilepsy durations30 and40 years. Conclusions The study did not find worse VNS outcomes, as defined by the 50R or 90R rate, in older adult patients or in patients with a longer epilepsy duration. The increasing stimulation effect over time is less marked in older patients and in patients with longer epilepsy duration.

Citovat

CHRASTINA, Jan, Jitka KOČVAROVÁ, Zdeněk NOVÁK, Irena DOLEŽALOVÁ, Michal SVOBODA a Milan BRÁZDIL. Older Age and Longer Epilepsy Duration Do Not Predict Worse Seizure Reduction Outcome after Vagus Nerve Stimulation. Journal of Neurological Surgery, Part A: Central European Neurosurgery. New York: Thieme Medical Publ Inc, 2018, roč. 79, č. 2, s. 152-158. ISSN 2193-6315. Dostupné z: https://dx.doi.org/10.1055/s-0037-1607396.

@article{1452036,
   author = {Chrastina, Jan and Kočvarová, Jitka and Novák, Zdeněk and Doležalová, Irena and Svoboda, Michal and Brázdil, Milan},
   article_location = {New York},
   article_number = {2},
   doi = {http://dx.doi.org/10.1055/s-0037-1607396},
   keywords = {epilepsy; vagus nerve stimulation; seizures reduction; responder},
   language = {eng},
   issn = {2193-6315},
   journal = {Journal of Neurological Surgery, Part A: Central European Neurosurgery},
   title = {Older Age and Longer Epilepsy Duration Do Not Predict Worse Seizure Reduction Outcome after Vagus Nerve Stimulation},
   volume = {79},
   year = {2018}
}

TY  - JOUR
ID  - 1452036
AU  - Chrastina, Jan - Kočvarová, Jitka - Novák, Zdeněk - Doležalová, Irena - Svoboda, Michal - Brázdil, Milan
PY  - 2018
TI  - Older Age and Longer Epilepsy Duration Do Not Predict Worse Seizure Reduction Outcome after Vagus Nerve Stimulation
JF  - Journal of Neurological Surgery, Part A: Central European Neurosurgery
VL  - 79
IS  - 2
SP  - 152-158
EP  - 152-158
PB  - Thieme Medical Publ Inc
SN  - 21936315
KW  - epilepsy
KW  - vagus nerve stimulation
KW  - seizures reduction
KW  - responder
N2  - Introduction We analyzed the results of vagus nerve stimulation (VNS) on older patients and patients with long-lasting epilepsy and included severely intellectually disabled patients. Patients and Methods A total of 103 adults with VNS implanted from 2005 to 2014 were studied. The responder rates, that is, the percentage of VNS patients who responded to VNS, classified as seizure reduction50% (50R) and seizure reduction90% (90R), were compared in defined age groups (< 40 and40 years, and<50 and50 years) and epilepsy duration groups (< 20 and20 years,<30 and30 years, and<40 and40 years) at the 1-year follow-up visit and the last follow-up visit (at least 2 years after surgery). The age distributions and responder rates were also studied in patients with an intellectual disability. Results The analysis did not confirm a significantly lower 50R or 90R rate in patients40,50, or60 years when compared with their younger counterparts, but the 50R rate increase during follow-up care was the lowest in patients50 and60 years. The highest percentage of patients with an intellectual disability in the group<40 years of age did not adversely affect the 50R rate. Longer epilepsy duration was not confirmed as a negative predictor of VNS outcome. There was a significantly higher 50R rate in patients with epilepsy duration20 years (at the last follow-up visit) and a higher 90R rate in patients with epilepsy duration30 years (at the 1-year follow-up visit). The increase in the 50R rate during follow-up care was lower in patients with epilepsy durations30 and40 years. Conclusions The study did not find worse VNS outcomes, as defined by the 50R or 90R rate, in older adult patients or in patients with a longer epilepsy duration. The increasing stimulation effect over time is less marked in older patients and in patients with longer epilepsy duration.
ER  -

CHRASTINA, Jan, Jitka KOČVAROVÁ, Zdeněk NOVÁK, Irena DOLEŽALOVÁ, Michal SVOBODA a Milan BRÁZDIL. Older Age and Longer Epilepsy Duration Do Not Predict Worse Seizure Reduction Outcome after Vagus Nerve Stimulation. \textit{Journal of Neurological Surgery, Part A: Central European Neurosurgery}. New York: Thieme Medical Publ Inc, 2018, roč.~79, č.~2, s.~152-158. ISSN~2193-6315. Dostupné z: https://dx.doi.org/10.1055/s-0037-1607396.

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