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@article{1453558, author = {Beňovská, Miroslava and Opluštilová, Aneta and Pinkavová, Jana and Hodická, Zuzana and Čermáková, Zdeňka}, article_location = {OXFORD}, article_number = {2}, doi = {http://dx.doi.org/10.1093/labmed/lmx076}, keywords = {preeclampsia; angiogenic factors; placental growth factor; sFlt-1; PIGF; sFlt-1/PIGF ratio}, language = {eng}, issn = {0007-5027}, journal = {LABORATORY MEDICINE}, title = {The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation}, volume = {49}, year = {2018} }
TY - JOUR ID - 1453558 AU - Beňovská, Miroslava - Opluštilová, Aneta - Pinkavová, Jana - Hodická, Zuzana - Čermáková, Zdeňka PY - 2018 TI - The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation JF - LABORATORY MEDICINE VL - 49 IS - 2 SP - 112-117 EP - 112-117 PB - OXFORD UNIV PRESS SN - 00075027 KW - preeclampsia KW - angiogenic factors KW - placental growth factor KW - sFlt-1 KW - PIGF KW - sFlt-1/PIGF ratio N2 - Background: Soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PIGF) ate used in diagnosing preeclampsia (PE), but their potential in early prediction in pregnant women at 16 to 20 weeks gestation (WG) has remained unexplored. Methods: We retrospectively measured serum levels of sFlt-1 and PIGF in 120 pregnant women at 16 to 20 WG. Among these women, 16 had early-onset PE and 23 had late-onset PE. Results: Compared with normal pregnancy values, in the serum of women in whom PE later developed, sFlt-1 values increased (P <.001), values of PIGF decreased (P = .001), and the sFlt-1/PIGF ratio increased (P <.001) as early as 16 to 20 WG. Receiver operating characteristic (ROC) curve analysis for the sFlt-1/PIGF ratio at 16 to 20 WG showed an area under the curve (AUC) value of 0.863 (95% confidence interval [CI], 0.788-0.918), P <.001, sensitivity of 74.4%, and specificity of 86.6 degrees k for PE in general; and AUC of 0.970 (95% CI, 0.913-0.994), P <.001, sensitivity of 100%, and specificity of 81.5% for early-onset PE only. Also, we determined the 5th and 95th percentiles for sFlt-1, PIGF, and sFlt-1/PIGF ratio values of healthy pregnant women. Conclusion: sFlt-1 and PIGF and, in particular, the sFlt-1/PIGF ratio can detect PE as early as 16 to 20 WG-as long as 10 to 15 weeks before PE onset. ER -
BEŇOVSKÁ, Miroslava, Aneta OPLUŠTILOVÁ, Jana PINKAVOVÁ, Zuzana HODICKÁ a Zdeňka ČERMÁKOVÁ. The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation. \textit{LABORATORY MEDICINE}. OXFORD: OXFORD UNIV PRESS, 2018, roč.~49, č.~2, s.~112-117. ISSN~0007-5027. Dostupné z: https://dx.doi.org/10.1093/labmed/lmx076.
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