The New Possibilities in Early Diagnosis of Preeclampsia by
Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor
in 16-20 Weeks Gestation

J 2018

The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation

BEŇOVSKÁ, Miroslava, Aneta OPLUŠTILOVÁ, Jana PINKAVOVÁ, Zuzana HODICKÁ, Zdeňka ČERMÁKOVÁ et. al.

Základní údaje

Originální název

The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation

Autoři

BEŇOVSKÁ, Miroslava (203 Česká republika, garant, domácí), Aneta OPLUŠTILOVÁ (203 Česká republika), Jana PINKAVOVÁ (203 Česká republika), Zuzana HODICKÁ (203 Česká republika, domácí) a Zdeňka ČERMÁKOVÁ (203 Česká republika, domácí)

Vydání

LABORATORY MEDICINE, OXFORD, OXFORD UNIV PRESS, 2018, 0007-5027

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

20602 Medical laboratory technology ;

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.020

Kód RIV

RIV/00216224:14110/18:00104136

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1093/labmed/lmx076

UT WoS

000435092600006

Klíčová slova anglicky

preeclampsia; angiogenic factors; placental growth factor; sFlt-1; PIGF; sFlt-1/PIGF ratio

Štítky

14110411, 14110616, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 2. 2019 14:14, Soňa Böhmová

Anotace

V originále

Background: Soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PIGF) ate used in diagnosing preeclampsia (PE), but their potential in early prediction in pregnant women at 16 to 20 weeks gestation (WG) has remained unexplored. Methods: We retrospectively measured serum levels of sFlt-1 and PIGF in 120 pregnant women at 16 to 20 WG. Among these women, 16 had early-onset PE and 23 had late-onset PE. Results: Compared with normal pregnancy values, in the serum of women in whom PE later developed, sFlt-1 values increased (P <.001), values of PIGF decreased (P = .001), and the sFlt-1/PIGF ratio increased (P <.001) as early as 16 to 20 WG. Receiver operating characteristic (ROC) curve analysis for the sFlt-1/PIGF ratio at 16 to 20 WG showed an area under the curve (AUC) value of 0.863 (95% confidence interval [CI], 0.788-0.918), P <.001, sensitivity of 74.4%, and specificity of 86.6 degrees k for PE in general; and AUC of 0.970 (95% CI, 0.913-0.994), P <.001, sensitivity of 100%, and specificity of 81.5% for early-onset PE only. Also, we determined the 5th and 95th percentiles for sFlt-1, PIGF, and sFlt-1/PIGF ratio values of healthy pregnant women. Conclusion: sFlt-1 and PIGF and, in particular, the sFlt-1/PIGF ratio can detect PE as early as 16 to 20 WG-as long as 10 to 15 weeks before PE onset.

Citovat

BEŇOVSKÁ, Miroslava, Aneta OPLUŠTILOVÁ, Jana PINKAVOVÁ, Zuzana HODICKÁ a Zdeňka ČERMÁKOVÁ. The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation. LABORATORY MEDICINE. OXFORD: OXFORD UNIV PRESS, 2018, roč. 49, č. 2, s. 112-117. ISSN 0007-5027. Dostupné z: https://dx.doi.org/10.1093/labmed/lmx076.

@article{1453558,
   author = {Beňovská, Miroslava and Opluštilová, Aneta and Pinkavová, Jana and Hodická, Zuzana and Čermáková, Zdeňka},
   article_location = {OXFORD},
   article_number = {2},
   doi = {http://dx.doi.org/10.1093/labmed/lmx076},
   keywords = {preeclampsia; angiogenic factors; placental growth factor; sFlt-1; PIGF; sFlt-1/PIGF ratio},
   language = {eng},
   issn = {0007-5027},
   journal = {LABORATORY MEDICINE},
   title = {The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation},
   volume = {49},
   year = {2018}
}

TY  - JOUR
ID  - 1453558
AU  - Beňovská, Miroslava - Opluštilová, Aneta - Pinkavová, Jana - Hodická, Zuzana - Čermáková, Zdeňka
PY  - 2018
TI  - The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation
JF  - LABORATORY MEDICINE
VL  - 49
IS  - 2
SP  - 112-117
EP  - 112-117
PB  - OXFORD UNIV PRESS
SN  - 00075027
KW  - preeclampsia
KW  - angiogenic factors
KW  - placental growth factor
KW  - sFlt-1
KW  - PIGF
KW  - sFlt-1/PIGF ratio
N2  - Background: Soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PIGF) ate used in diagnosing preeclampsia (PE), but their potential in early prediction in pregnant women at 16 to 20 weeks gestation (WG) has remained unexplored. Methods: We retrospectively measured serum levels of sFlt-1 and PIGF in 120 pregnant women at 16 to 20 WG. Among these women, 16 had early-onset PE and 23 had late-onset PE. Results: Compared with normal pregnancy values, in the serum of women in whom PE later developed, sFlt-1 values increased (P <.001), values of PIGF decreased (P = .001), and the sFlt-1/PIGF ratio increased (P <.001) as early as 16 to 20 WG. Receiver operating characteristic (ROC) curve analysis for the sFlt-1/PIGF ratio at 16 to 20 WG showed an area under the curve (AUC) value of 0.863 (95% confidence interval [CI], 0.788-0.918), P <.001, sensitivity of 74.4%, and specificity of 86.6 degrees k for PE in general; and AUC of 0.970 (95% CI, 0.913-0.994), P <.001, sensitivity of 100%, and specificity of 81.5% for early-onset PE only. Also, we determined the 5th and 95th percentiles for sFlt-1, PIGF, and sFlt-1/PIGF ratio values of healthy pregnant women. Conclusion: sFlt-1 and PIGF and, in particular, the sFlt-1/PIGF ratio can detect PE as early as 16 to 20 WG-as long as 10 to 15 weeks before PE onset.
ER  -

BEŇOVSKÁ, Miroslava, Aneta OPLUŠTILOVÁ, Jana PINKAVOVÁ, Zuzana HODICKÁ a Zdeňka ČERMÁKOVÁ. The New Possibilities in Early Diagnosis of Preeclampsia by Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor in 16-20 Weeks Gestation. \textit{LABORATORY MEDICINE}. OXFORD: OXFORD UNIV PRESS, 2018, roč.~49, č.~2, s.~112-117. ISSN~0007-5027. Dostupné z: https://dx.doi.org/10.1093/labmed/lmx076.

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