Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study

HRUSKOVA, Jana, Andrea MAUGERI, Helena PODROUŽKOVÁ, Tatiana ŠTÍPALOVÁ, Juraj JAKUBÍK, Martina BARCHITTA, Jose R. MEDINA-INOJOSA, Martin HOMOLKA, Antonella AGODI, Šárka KUNZOVÁ, Ondřej SOCHOR, Francisco LOPEZ-JIMENEZ a Manlio VINCIGUERRA. Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study. JOURNAL OF CLINICAL MEDICINE. BASEL: MDPI, 2018, roč. 7, č. 5, s. 1-13. ISSN 2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm7050113.

Základní údaje

Originální název

Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study

Autoři

HRUSKOVA, Jana (203 Česká republika), Andrea MAUGERI (203 Česká republika), Helena PODROUŽKOVÁ (203 Česká republika, domácí), Tatiana ŠTÍPALOVÁ (703 Slovensko, domácí), Juraj JAKUBÍK (703 Slovensko), Martina BARCHITTA (380 Itálie), Jose R. MEDINA-INOJOSA (840 Spojené státy), Martin HOMOLKA (203 Česká republika), Antonella AGODI (380 Itálie), Šárka KUNZOVÁ (203 Česká republika), Ondřej SOCHOR (203 Česká republika), Francisco LOPEZ-JIMENEZ (840 Spojené státy) a Manlio VINCIGUERRA (380 Itálie, garant)

Vydání

JOURNAL OF CLINICAL MEDICINE, BASEL, MDPI, 2018, 2077-0383

---

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 5.688

Kód RIV

RIV/00216224:14110/18:00104138

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/jcm7050113

UT WoS

000435194400026

Klíčová slova anglicky

cardiovascular risk; epicardial adipose tissue; intima media thickness

Štítky

14110115, rivok

Příznaky

Mezinárodní význam, Recenzováno

---

Anotace

V originále

Background: Intima-media thickness (IMT) has been proposed as a measurement of subclinical atherosclerosis and has been associated with cardiovascular disease (CVD). Epicardial adipose tissue (EAT) is a fat depot between the pericardium and myocardium and has been associated with coronary atherosclerosis. The relationship between IMT and EAT thickness has not been reported before. We investigated the relationship between EAT thickness, IMT, CVD risk factors, and ideal cardiovascular health (CVH) metrics using subjects from the Kardiovize Brno 2030 cohort study, a random urban sample population in Central Europe. Methods: We studied 102 individuals (65 males) aged 25-64 years (median = 37 years) with no current or past CVD history. We measured IMT using a vascular ultrasound and EAT thickness using transthoracic echocardiography, and collected data on anthropometric factors, CVD risk factors, and CVH score. Correlation tests and multiple linear regression models were applied. Results: In the age- and gender-adjusted model, we demonstrated that, among CVD risk factors, only BMI was significantly and positively associated with EAT thickness ( = 0.182, SE = 0.082, p = 0.030), while no significant associations with IMT were evident. Although both EAT thickness and IMT were negatively correlated with CVH score (r = -0.45, p < 0.001, and r = -0.38, p < 0.001, respectively), we demonstrated that overall CVH score (beta = -0.262; SE = 0.077; p = 0.001), as well as BMI (beta = -1.305; SE = 0.194; p < 0.001) and blood pressure CVH metrics (beta = -0.607; SE = 0.206; p = 0.004) were significantly associated with EAT thickness but not with IMT. Conclusions: Our study is important as it demonstrated for the first time that CVH is associated with EAT thickness. Interestingly, this relationship seems to be dependent on BMI and blood pressure rather than on the other CVH metrics. However, outcome-driven studies are required to confirm these findings.