| VŠIANSKÝ, Vít, Jaromír GUMULEC, Martina RAUDENSKÁ a Michal MASAŘÍK. Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2018, roč. 8, č. 10370, s. 1-7. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-018-28672-8. |
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@article{1454676,
author = {Všianský, Vít and Gumulec, Jaromír and Raudenská, Martina and Masařík, Michal},
article_location = {LONDON},
article_number = {10370},
doi = {http://dx.doi.org/10.1038/s41598-018-28672-8},
keywords = {c-Met},
language = {eng},
issn = {2045-2322},
journal = {Scientific reports},
title = {Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis},
volume = {8},
year = {2018}
}
TY - JOUR
ID - 1454676
AU - Všianský, Vít - Gumulec, Jaromír - Raudenská, Martina - Masařík, Michal
PY - 2018
TI - Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis
JF - Scientific reports
VL - 8
IS - 10370
SP - 1-7
EP - 1-7
PB - NATURE PUBLISHING GROUP
SN - 20452322
KW - c-Met
N2 - This meta-analysis aims to evaluate the effects of high c-Met levels in head and neck squamous cell carcinomas (HNSCC) on survival and clinicopathological features. Publications concerned with the clinical significance of c-Met protein expression in HNSCC were identified from the Scopus and Web of Science database searches. To elucidate the relationship between c-Met expression and clinical outcomes, a meta-analysis of the selected articles was conducted. Seventeen publications involving a total of 1724 patients met the inclusion criteria. c-Met overexpression was significantly correlated with poor overall survival (hazard ratio (HR) = 2.19, 95% confidence interval (CI) = 1.55-3.10). c-Met immunohistochemical staining positivity was also associated with worse relapse-free survival (HR = 1.64, 95% CI = 1.24-2.17) and presence of regional lymph node metastases (odds ratio (OR) = 1.76, 95% CI = 1.26-2.45). High levels of c-Met expression in HNSCC predict unfavorable prognosis associated with common clinicopathological features.
ER -
VŠIANSKÝ, Vít, Jaromír GUMULEC, Martina RAUDENSKÁ a Michal MASAŘÍK. Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2018, roč.~8, č.~10370, s.~1-7. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-018-28672-8.
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