Prognostic role of c-Met in head and neck squamous cell cancer
tissues: a meta-analysis

J 2018

Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis

VŠIANSKÝ, Vít, Jaromír GUMULEC, Martina RAUDENSKÁ a Michal MASAŘÍK

Základní údaje

Originální název

Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis

Autoři

VŠIANSKÝ, Vít (203 Česká republika, domácí), Jaromír GUMULEC (203 Česká republika, garant, domácí), Martina RAUDENSKÁ (203 Česká republika, domácí) a Michal MASAŘÍK (203 Česká republika, domácí)

Vydání

Scientific reports, LONDON, NATURE PUBLISHING GROUP, 2018, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.011

Kód RIV

RIV/00216224:14110/18:00106938

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/s41598-018-28672-8

UT WoS

000438024500002

Klíčová slova anglicky

c-Met

Štítky

14110515, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 2. 2019 18:11, Soňa Böhmová

Anotace

V originále

This meta-analysis aims to evaluate the effects of high c-Met levels in head and neck squamous cell carcinomas (HNSCC) on survival and clinicopathological features. Publications concerned with the clinical significance of c-Met protein expression in HNSCC were identified from the Scopus and Web of Science database searches. To elucidate the relationship between c-Met expression and clinical outcomes, a meta-analysis of the selected articles was conducted. Seventeen publications involving a total of 1724 patients met the inclusion criteria. c-Met overexpression was significantly correlated with poor overall survival (hazard ratio (HR) = 2.19, 95% confidence interval (CI) = 1.55-3.10). c-Met immunohistochemical staining positivity was also associated with worse relapse-free survival (HR = 1.64, 95% CI = 1.24-2.17) and presence of regional lymph node metastases (odds ratio (OR) = 1.76, 95% CI = 1.26-2.45). High levels of c-Met expression in HNSCC predict unfavorable prognosis associated with common clinicopathological features.

Návaznosti

NV16-29835A, projekt VaV

Název: Molekulárně-genetické markery predikce účinnosti radioterapie u nádorů hlavy a krku

ROZV/25/LF/2017, interní kód MU

Název: LF - Příspěvek na IP 2017

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek na IP 2017, Interní rozvojové projekty

Citovat

VŠIANSKÝ, Vít, Jaromír GUMULEC, Martina RAUDENSKÁ a Michal MASAŘÍK. Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2018, roč. 8, č. 10370, s. 1-7. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-018-28672-8.

@article{1454676,
   author = {Všianský, Vít and Gumulec, Jaromír and Raudenská, Martina and Masařík, Michal},
   article_location = {LONDON},
   article_number = {10370},
   doi = {http://dx.doi.org/10.1038/s41598-018-28672-8},
   keywords = {c-Met},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis},
   volume = {8},
   year = {2018}
}

TY  - JOUR
ID  - 1454676
AU  - Všianský, Vít - Gumulec, Jaromír - Raudenská, Martina - Masařík, Michal
PY  - 2018
TI  - Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis
JF  - Scientific reports
VL  - 8
IS  - 10370
SP  - 1-7
EP  - 1-7
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
KW  - c-Met
N2  - This meta-analysis aims to evaluate the effects of high c-Met levels in head and neck squamous cell carcinomas (HNSCC) on survival and clinicopathological features. Publications concerned with the clinical significance of c-Met protein expression in HNSCC were identified from the Scopus and Web of Science database searches. To elucidate the relationship between c-Met expression and clinical outcomes, a meta-analysis of the selected articles was conducted. Seventeen publications involving a total of 1724 patients met the inclusion criteria. c-Met overexpression was significantly correlated with poor overall survival (hazard ratio (HR) = 2.19, 95% confidence interval (CI) = 1.55-3.10). c-Met immunohistochemical staining positivity was also associated with worse relapse-free survival (HR = 1.64, 95% CI = 1.24-2.17) and presence of regional lymph node metastases (odds ratio (OR) = 1.76, 95% CI = 1.26-2.45). High levels of c-Met expression in HNSCC predict unfavorable prognosis associated with common clinicopathological features.
ER  -

VŠIANSKÝ, Vít, Jaromír GUMULEC, Martina RAUDENSKÁ a Michal MASAŘÍK. Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2018, roč.~8, č.~10370, s.~1-7. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-018-28672-8.

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