KARÁSEK, Petr, Natalia Anna GABŁO, Jan HLAVSA, Igor KISS, Petra VYCHYTILOVÁ, Markéta HERMANOVÁ, Zdeněk KALA, Ondřej SLABÝ a Vladimír PROCHÁZKA. Pre-operative Plasma miR-21-5p Is a Sensitive Biomarker and Independent Prognostic Factor in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Surgical Resection. CANCER GENOMICS & PROTEOMICS. ATHENS: INT INST ANTICANCER RESEARCH, 2018, roč. 15, č. 4, s. 321-327. ISSN 1109-6535. Dostupné z: https://dx.doi.org/10.21873/cgp.20090. |
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@article{1454917, author = {Karásek, Petr and Gabło, Natalia Anna and Hlavsa, Jan and Kiss, Igor and Vychytilová, Petra and Hermanová, Markéta and Kala, Zdeněk and Slabý, Ondřej and Procházka, Vladimír}, article_location = {ATHENS}, article_number = {4}, doi = {http://dx.doi.org/10.21873/cgp.20090}, keywords = {Pancreatic ductal adenocarcinoma; microRNAs; plasma; miR-21-5p; diagnosis; prognosis}, language = {eng}, issn = {1109-6535}, journal = {CANCER GENOMICS & PROTEOMICS}, title = {Pre-operative Plasma miR-21-5p Is a Sensitive Biomarker and Independent Prognostic Factor in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Surgical Resection}, volume = {15}, year = {2018} }
TY - JOUR ID - 1454917 AU - Karásek, Petr - Gabło, Natalia Anna - Hlavsa, Jan - Kiss, Igor - Vychytilová, Petra - Hermanová, Markéta - Kala, Zdeněk - Slabý, Ondřej - Procházka, Vladimír PY - 2018 TI - Pre-operative Plasma miR-21-5p Is a Sensitive Biomarker and Independent Prognostic Factor in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Surgical Resection JF - CANCER GENOMICS & PROTEOMICS VL - 15 IS - 4 SP - 321-327 EP - 321-327 PB - INT INST ANTICANCER RESEARCH SN - 11096535 KW - Pancreatic ductal adenocarcinoma KW - microRNAs KW - plasma KW - miR-21-5p KW - diagnosis KW - prognosis N2 - Blood plasma microRNAs (miRNAs) are emerging as a clinically useful tool for non-invasive detection and prognosis estimation in various cancer types including pancreatic ductal adenocarcinoma (PDAC). The aim of the present study was to provide an independent validation of circulating miRNAs identified in previous studies as diagnostic and/or prognostic biomarkers in PDAC. Based on the literature search, 6 miRNAs were chosen as candidates for independent validation; miR-21-5p, miR-375, miR-155, miR-17-5p, miR-126-5p and miR-1290. Validation of these miRNAs was performed in a cohort of 25 patients with PDAC undergoing surgical resection and 24 healthy donors. Plasma levels of miRNAs were determined using quantitative real-time PCR. We confirmed significantly higher levels of all tested miRNA in blood plasma of PDAC patients in comparison to healthy controls with miR-21-5p showing the highest analytical performance (p<0.001; AUC>0.99). Increased levels of miR-21-5p (p=0.045) and miR-375 (p=0.013) were significantly associated with overall survival. Multivariate analysis demonstrated that miR-21-5p is a significant unfavorable prognostic factor independent on other clinical variables including adjuvant chemotherapy (hazard ratio 2.95; 95% CI 1.06-8.18; p=0.038). Our preliminary data indicate promising diagnostic and prognostic utility of plasma miR-21-5p in PDAC patients. ER -
KARÁSEK, Petr, Natalia Anna GABŁO, Jan HLAVSA, Igor KISS, Petra VYCHYTILOVÁ, Markéta HERMANOVÁ, Zdeněk KALA, Ondřej SLABÝ a Vladimír PROCHÁZKA. Pre-operative Plasma miR-21-5p Is a Sensitive Biomarker and Independent Prognostic Factor in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Surgical Resection. \textit{CANCER GENOMICS \&{}amp; PROTEOMICS}. ATHENS: INT INST ANTICANCER RESEARCH, 2018, roč.~15, č.~4, s.~321-327. ISSN~1109-6535. Dostupné z: https://dx.doi.org/10.21873/cgp.20090.
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