Association of interleukin 6, interleukin 7 receptor alpha, and
interleukin 12B gene polymorphisms with multiple sclerosis

J 2018

Association of interleukin 6, interleukin 7 receptor alpha, and interleukin 12B gene polymorphisms with multiple sclerosis

BENEŠOVÁ, Yvonne, Anna VAŠKŮ a Julie BIENERTOVÁ VAŠKŮ

Základní údaje

Originální název

Association of interleukin 6, interleukin 7 receptor alpha, and interleukin 12B gene polymorphisms with multiple sclerosis

Autoři

BENEŠOVÁ, Yvonne (203 Česká republika, garant, domácí), Anna VAŠKŮ (203 Česká republika, domácí) a Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, domácí)

Vydání

Acta Neurologica Belgica, Heidelberg, Springer Heidelberg, 2018, 0300-9009

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.612

Kód RIV

RIV/00216224:14110/18:00104199

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s13760-018-0994-9

UT WoS

000442249600020

Klíčová slova anglicky

Gene; Interleukin 6; Interleukin 7 receptor alpha chain; Interleukin 12B; Multiple sclerosis; Single nucleotide polymorphism

Štítky

14110221, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 2. 2019 20:48, Soňa Böhmová

Anotace

V originále

Pro-inflammatory and anti-inflammatory cytokines have been shown to play a crucial role in the pathophysiology of multiple sclerosis (MS). We investigated the association between interleukin (IL) IL6-174 G/C (rs1800795), IL7RA C/T (rs6897932), and IL-12B A1188C (rs3212227) gene polymorphisms (SNPs) and MS. The study consisted of 297 unrelated MS patients and 135 healthy individuals. In IL6-174G/C (rs1800795), a significant association between the C allele and MS risk [OR 1.41, 95% CI (1.05-1.92); P = 0.025] was found. Carriage of genotypes CC and CG were more common in MS patients [OR 1.58, 95% CI (1.04-2.39); P = 0.031] and also in female MS patients [OR 1.68, 95% CI (1.02-2.79); P = 0.043]. However, after applying Bonferroni's correction the differences did not remain significant. No significant association between the IL7RA C/T (rs6897932) and IL12B A1188C (rs3212227) gene polymorphisms and MS susceptibility was observed. Regarding IL-12B A1188C (rs3212227), a significant association between the CC genotype and MS progression, expressed as MSSS, was demonstrated in the female MS group. Our results indicate that the distribution of IL6-174G/C (rs1800795) SNP was marginally associated with MS susceptibility. We also showed that IL-12B A1188C (rs3212227) can contribute to the progression of the disease in the Czech population.

Návaznosti

MUNI/A/1426/2015, interní kód MU

Název: Genetická a epigenetická patofyziologie vybraných stavů (Akronym: Genetika a epigenetika)

Investor: Masarykova univerzita, Genetická a epigenetická patofyziologie vybraných stavů, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

BENEŠOVÁ, Yvonne, Anna VAŠKŮ a Julie BIENERTOVÁ VAŠKŮ. Association of interleukin 6, interleukin 7 receptor alpha, and interleukin 12B gene polymorphisms with multiple sclerosis. Acta Neurologica Belgica. Heidelberg: Springer Heidelberg, 2018, roč. 118, č. 3, s. 493-501. ISSN 0300-9009. Dostupné z: https://dx.doi.org/10.1007/s13760-018-0994-9.

@article{1455316,
   author = {Benešová, Yvonne and Vašků, Anna and Bienertová Vašků, Julie},
   article_location = {Heidelberg},
   article_number = {3},
   doi = {http://dx.doi.org/10.1007/s13760-018-0994-9},
   keywords = {Gene; Interleukin 6; Interleukin 7 receptor alpha chain; Interleukin 12B; Multiple sclerosis; Single nucleotide polymorphism},
   language = {eng},
   issn = {0300-9009},
   journal = {Acta Neurologica Belgica},
   title = {Association of interleukin 6, interleukin 7 receptor alpha, and interleukin 12B gene polymorphisms with multiple sclerosis},
   volume = {118},
   year = {2018}
}

TY  - JOUR
ID  - 1455316
AU  - Benešová, Yvonne - Vašků, Anna - Bienertová Vašků, Julie
PY  - 2018
TI  - Association of interleukin 6, interleukin 7 receptor alpha, and interleukin 12B gene polymorphisms with multiple sclerosis
JF  - Acta Neurologica Belgica
VL  - 118
IS  - 3
SP  - 493-501
EP  - 493-501
PB  - Springer Heidelberg
SN  - 03009009
KW  - Gene
KW  - Interleukin 6
KW  - Interleukin 7 receptor alpha chain
KW  - Interleukin 12B
KW  - Multiple sclerosis
KW  - Single nucleotide polymorphism
N2  - Pro-inflammatory and anti-inflammatory cytokines have been shown to play a crucial role in the pathophysiology of multiple sclerosis (MS). We investigated the association between interleukin (IL) IL6-174 G/C (rs1800795), IL7RA C/T (rs6897932), and IL-12B A1188C (rs3212227) gene polymorphisms (SNPs) and MS. The study consisted of 297 unrelated MS patients and 135 healthy individuals. In IL6-174G/C (rs1800795), a significant association between the C allele and MS risk [OR 1.41, 95% CI (1.05-1.92); P = 0.025] was found. Carriage of genotypes CC and CG were more common in MS patients [OR 1.58, 95% CI (1.04-2.39); P = 0.031] and also in female MS patients [OR 1.68, 95% CI (1.02-2.79); P = 0.043]. However, after applying Bonferroni's correction the differences did not remain significant. No significant association between the IL7RA C/T (rs6897932) and IL12B A1188C (rs3212227) gene polymorphisms and MS susceptibility was observed. Regarding IL-12B A1188C (rs3212227), a significant association between the CC genotype and MS progression, expressed as MSSS, was demonstrated in the female MS group. Our results indicate that the distribution of IL6-174G/C (rs1800795) SNP was marginally associated with MS susceptibility. We also showed that IL-12B A1188C (rs3212227) can contribute to the progression of the disease in the Czech population.
ER  -

BENEŠOVÁ, Yvonne, Anna VAŠKŮ a Julie BIENERTOVÁ VAŠKŮ. Association of interleukin 6, interleukin 7 receptor alpha, and interleukin 12B gene polymorphisms with multiple sclerosis. \textit{Acta Neurologica Belgica}. Heidelberg: Springer Heidelberg, 2018, roč.~118, č.~3, s.~493-501. ISSN~0300-9009. Dostupné z: https://dx.doi.org/10.1007/s13760-018-0994-9.

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