Toxic epidermal necrolysis data from the CELESTE multinational
registry. Part I: Epidemiology and general microbiological
characteristics

J 2018

Toxic epidermal necrolysis data from the CELESTE multinational registry. Part I: Epidemiology and general microbiological characteristics

LIPOVÝ, Břetislav, Jakub HOLOUBEK, Markéta HANSLIANOVÁ, Michaela CVANOVÁ, L. KLEIN et. al.

Základní údaje

Originální název

Toxic epidermal necrolysis data from the CELESTE multinational registry. Part I: Epidemiology and general microbiological characteristics

Autoři

LIPOVÝ, Břetislav (203 Česká republika, garant, domácí), Jakub HOLOUBEK (203 Česká republika), Markéta HANSLIANOVÁ (203 Česká republika), Michaela CVANOVÁ (203 Česká republika, domácí), L. KLEIN (203 Česká republika), I. GROSSOVÁ (203 Česká republika), R. ZAJÍČEK (203 Česká republika), P. BUKOVČAN (203 Česká republika), J. KOLLER (203 Česká republika), M. BARAN (203 Česká republika), P. LENGYEL (203 Česká republika), L. EIMER (203 Česká republika), M. JANDOVÁ (203 Česká republika), M. KOŠŤÁL (203 Česká republika) a Pavel BRYCHTA (203 Česká republika, domácí)

Vydání

Burns, OXFORD, ELSEVIER SCI LTD, 2018, 0305-4179

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30212 Surgery

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.247

Kód RIV

RIV/00216224:14110/18:00104205

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.burns.2018.01.019

UT WoS

000444542300020

Klíčová slova anglicky

Toxic epidermal necrolysis; Infectious complications; CELESTE registry

Štítky

14110229, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 2. 2019 14:29, Soňa Böhmová

Anotace

V originále

Introduction: Toxic epidermal necrolysis (TEN) is a rare, life-threatening autoimmune disease predominantly manifested in the skin and mucous membranes. Today, infectious complications have the dominant share in mortality of TEN patients. Due to the nature of the therapy and administration of immunosuppressive medications, a wide range of potentially pathogenic microorganisms, which cause infectious complications in different compartments in these patients, is not surprising. Material and methodology: This is a multicentric study, which included all patients with TEN hospitalized between 2000-2015 in specialized centres in the Czech Republic and Slovakia. The total catchment area was over 12.5 million inhabitants. The actual implementation of the project was carried out using data obtained from the registry CELESTE (Central European LyEll Syndrome: Therapeutic Evaluation), when specific parameters relating to epidemiological indicators and infectious complications in patients with TEN were evaluated in the form of a retrospective analysis. Results: In total, 39 patients with TEN were included in the study (12 patients died, mortality was 31%), who were hospitalized in the monitored period. The median age of patients in the group was 63 years (the range was 4-83 years, the mean was 51 years), the median of the exfoliated area was 70% TBSA (total body surface area) (range 30-100%, mean 67%). SCORTEN was calculated for 38 patients on the day of admission. Its median in all patients was 3 (range 1-6; mean 3). Any kind of infectious complication in the study group was recorded in 33 patients in total (85%). In total, 30 patients (77%) were infected with gram-positive cocci, 27 patients (69%) with gram-negative rods, and yeast cells or fibrous sponge were cultivated in 12 patients (31%). A total of 32 patients (82%) were found to have infectious complications in the exfoliated area, 15 patients (39%) had lower respiratory tract infections, 18 patients (46%) urinary tract infections and 15 patients (39%) an infection in the bloodstream. The most common potentially pathogenic microorganism isolated in our study group was coagulase neg. Staphylococcus, which caused infectious complications in 24 patients. Enterococcus faecalis/faecium (19 patients), Pseudomonas aeruginosa (17 patients), Staphylococcus aureus (11 patients) and Escherichia coli (11 patients) were other most frequently isolated micro-organisms. Conclusion: The published data were obtained from the unique registry of TEN patients in Central Europe. In the first part, we have succeeded in defining the basic epidemiological indicators in the group of patients anonymously included in this registry. The study clearly confirms that infectious complications currently play an essential role in TEN patients, often limiting the chances of survival. The study also shows a high prevalence of these complications in the period after 15 days from the start of hospitalization, when most patients already have completely regenerated skin cover. (C) 2018 Elsevier Ltd and ISBI. All rights reserved.

Citovat

LIPOVÝ, Břetislav, Jakub HOLOUBEK, Markéta HANSLIANOVÁ, Michaela CVANOVÁ, L. KLEIN, I. GROSSOVÁ, R. ZAJÍČEK, P. BUKOVČAN, J. KOLLER, M. BARAN, P. LENGYEL, L. EIMER, M. JANDOVÁ, M. KOŠŤÁL a Pavel BRYCHTA. Toxic epidermal necrolysis data from the CELESTE multinational registry. Part I: Epidemiology and general microbiological characteristics. Burns. OXFORD: ELSEVIER SCI LTD, 2018, roč. 44, č. 6, s. 1551-1560. ISSN 0305-4179. Dostupné z: https://dx.doi.org/10.1016/j.burns.2018.01.019.

@article{1455657,
   author = {Lipový, Břetislav and Holoubek, Jakub and Hanslianová, Markéta and Cvanová, Michaela and Klein, L. and Grossová, I. and Zajíček, R. and Bukovčan, P. and Koller, J. and Baran, M. and Lengyel, P. and Eimer, L. and Jandová, M. and Košťál, M. and Brychta, Pavel},
   article_location = {OXFORD},
   article_number = {6},
   doi = {http://dx.doi.org/10.1016/j.burns.2018.01.019},
   keywords = {Toxic epidermal necrolysis; Infectious complications; CELESTE registry},
   language = {eng},
   issn = {0305-4179},
   journal = {Burns},
   title = {Toxic epidermal necrolysis data from the CELESTE multinational registry. Part I: Epidemiology and general microbiological characteristics},
   volume = {44},
   year = {2018}
}

TY  - JOUR
ID  - 1455657
AU  - Lipový, Břetislav - Holoubek, Jakub - Hanslianová, Markéta - Cvanová, Michaela - Klein, L. - Grossová, I. - Zajíček, R. - Bukovčan, P. - Koller, J. - Baran, M. - Lengyel, P. - Eimer, L. - Jandová, M. - Košťál, M. - Brychta, Pavel
PY  - 2018
TI  - Toxic epidermal necrolysis data from the CELESTE multinational registry. Part I: Epidemiology and general microbiological characteristics
JF  - Burns
VL  - 44
IS  - 6
SP  - 1551-1560
EP  - 1551-1560
PB  - ELSEVIER SCI LTD
SN  - 03054179
KW  - Toxic epidermal necrolysis
KW  - Infectious complications
KW  - CELESTE registry
N2  - Introduction: Toxic epidermal necrolysis (TEN) is a rare, life-threatening autoimmune disease predominantly manifested in the skin and mucous membranes. Today, infectious complications have the dominant share in mortality of TEN patients. Due to the nature of the therapy and administration of immunosuppressive medications, a wide range of potentially pathogenic microorganisms, which cause infectious complications in different compartments in these patients, is not surprising. Material and methodology: This is a multicentric study, which included all patients with TEN hospitalized between 2000-2015 in specialized centres in the Czech Republic and Slovakia. The total catchment area was over 12.5 million inhabitants. The actual implementation of the project was carried out using data obtained from the registry CELESTE (Central European LyEll Syndrome: Therapeutic Evaluation), when specific parameters relating to epidemiological indicators and infectious complications in patients with TEN were evaluated in the form of a retrospective analysis. Results: In total, 39 patients with TEN were included in the study (12 patients died, mortality was 31%), who were hospitalized in the monitored period. The median age of patients in the group was 63 years (the range was 4-83 years, the mean was 51 years), the median of the exfoliated area was 70% TBSA (total body surface area) (range 30-100%, mean 67%). SCORTEN was calculated for 38 patients on the day of admission. Its median in all patients was 3 (range 1-6; mean 3). Any kind of infectious complication in the study group was recorded in 33 patients in total (85%). In total, 30 patients (77%) were infected with gram-positive cocci, 27 patients (69%) with gram-negative rods, and yeast cells or fibrous sponge were cultivated in 12 patients (31%). A total of 32 patients (82%) were found to have infectious complications in the exfoliated area, 15 patients (39%) had lower respiratory tract infections, 18 patients (46%) urinary tract infections and 15 patients (39%) an infection in the bloodstream. The most common potentially pathogenic microorganism isolated in our study group was coagulase neg. Staphylococcus, which caused infectious complications in 24 patients. Enterococcus faecalis/faecium (19 patients), Pseudomonas aeruginosa (17 patients), Staphylococcus aureus (11 patients) and Escherichia coli (11 patients) were other most frequently isolated micro-organisms. Conclusion: The published data were obtained from the unique registry of TEN patients in Central Europe. In the first part, we have succeeded in defining the basic epidemiological indicators in the group of patients anonymously included in this registry. The study clearly confirms that infectious complications currently play an essential role in TEN patients, often limiting the chances of survival. The study also shows a high prevalence of these complications in the period after 15 days from the start of hospitalization, when most patients already have completely regenerated skin cover. (C) 2018 Elsevier Ltd and ISBI. All rights reserved.
ER  -

LIPOVÝ, Břetislav, Jakub HOLOUBEK, Markéta HANSLIANOVÁ, Michaela CVANOVÁ, L. KLEIN, I. GROSSOVÁ, R. ZAJÍČEK, P. BUKOVČAN, J. KOLLER, M. BARAN, P. LENGYEL, L. EIMER, M. JANDOVÁ, M. KOŠŤÁL a Pavel BRYCHTA. Toxic epidermal necrolysis data from the CELESTE multinational registry. Part I: Epidemiology and general microbiological characteristics. \textit{Burns}. OXFORD: ELSEVIER SCI LTD, 2018, roč.~44, č.~6, s.~1551-1560. ISSN~0305-4179. Dostupné z: https://dx.doi.org/10.1016/j.burns.2018.01.019.

Podrobný výpis o publikaci