Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis
or Memory B Cell Formation in IGHD Haploinsufficient Humans

J 2018

Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans

NECHVÁTALOVÁ, Jana, Sophinus J. W. BARTOL, Zita CHOVANCOVÁ, Louis BOON, Marcela VLKOVÁ et. al.

Základní údaje

Originální název

Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans

Autoři

NECHVÁTALOVÁ, Jana (203 Česká republika, domácí), Sophinus J. W. BARTOL (528 Nizozemské království), Zita CHOVANCOVÁ (203 Česká republika, domácí), Louis BOON (528 Nizozemské království), Marcela VLKOVÁ (203 Česká republika, domácí) a Menno C. van ZELM (528 Nizozemské království, garant)

Vydání

Journal of immunology, Bethesda, American association of immunologists, 2018, 0022-1767

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.718

Kód RIV

RIV/00216224:14110/18:00106940

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4049/jimmunol.1800767

UT WoS

000444804300014

Klíčová slova anglicky

Surface IgD

Štítky

14110114, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 2. 2019 19:54, Soňa Böhmová

Anotace

V originále

Surface IgD is coexpressed with IgM on naive mature B cells. Still, the role of surface IgD remains enigmatic even 50 y after its initial discovery. In this study, we examined the in vivo role of surface IgD in human B cell homeostasis and Ab responses in four individuals with heterozygous nonsense mutations in IGHD. All IGHD heterozygous individuals had normal numbers of B cells and serum Igs and did not show signs of immunodeficiency or immune dysregulation. IgD(+) and IgD(-) naive mature B cells were present in equal numbers and showed similar immunophenotypes, except for decreased expression of CD79b in the IgD(-) subset. Furthermore, both IgD(+) and IgD(-) naive mature B cells had normal replication histories and similar capacities to differentiate into plasma cells upon in vitro stimulation, and Ig class-switched memory B cells showed similar levels of somatic hypermutations. Thus, human B cells lacking IgD expression develop normally and generate immunological memory in vivo, suggesting that surface IgD might function more restrictedly in regulating of B cell activation to specific antigenic structures.

Návaznosti

NV15-28732A, projekt VaV

Název: Vliv granulocytů a monocytů na vznik a rozvoj imunodeficitních chorob a dalších imunopatologických dějů

Citovat

NECHVÁTALOVÁ, Jana, Sophinus J. W. BARTOL, Zita CHOVANCOVÁ, Louis BOON, Marcela VLKOVÁ a Menno C. van ZELM. Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans. Journal of immunology. Bethesda: American association of immunologists, 2018, roč. 201, č. 7, s. 1928-1935. ISSN 0022-1767. Dostupné z: https://dx.doi.org/10.4049/jimmunol.1800767.

@article{1455936,
   author = {Nechvátalová, Jana and Bartol, Sophinus J. W. and Chovancová, Zita and Boon, Louis and Vlková, Marcela and Zelm, Menno C. van},
   article_location = {Bethesda},
   article_number = {7},
   doi = {http://dx.doi.org/10.4049/jimmunol.1800767},
   keywords = {Surface IgD},
   language = {eng},
   issn = {0022-1767},
   journal = {Journal of immunology},
   title = {Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans},
   volume = {201},
   year = {2018}
}

TY  - JOUR
ID  - 1455936
AU  - Nechvátalová, Jana - Bartol, Sophinus J. W. - Chovancová, Zita - Boon, Louis - Vlková, Marcela - Zelm, Menno C. van
PY  - 2018
TI  - Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans
JF  - Journal of immunology
VL  - 201
IS  - 7
SP  - 1928-1935
EP  - 1928-1935
PB  - American association of immunologists
SN  - 00221767
KW  - Surface IgD
N2  - Surface IgD is coexpressed with IgM on naive mature B cells. Still, the role of surface IgD remains enigmatic even 50 y after its initial discovery. In this study, we examined the in vivo role of surface IgD in human B cell homeostasis and Ab responses in four individuals with heterozygous nonsense mutations in IGHD. All IGHD heterozygous individuals had normal numbers of B cells and serum Igs and did not show signs of immunodeficiency or immune dysregulation. IgD(+) and IgD(-) naive mature B cells were present in equal numbers and showed similar immunophenotypes, except for decreased expression of CD79b in the IgD(-) subset. Furthermore, both IgD(+) and IgD(-) naive mature B cells had normal replication histories and similar capacities to differentiate into plasma cells upon in vitro stimulation, and Ig class-switched memory B cells showed similar levels of somatic hypermutations. Thus, human B cells lacking IgD expression develop normally and generate immunological memory in vivo, suggesting that surface IgD might function more restrictedly in regulating of B cell activation to specific antigenic structures.
ER  -

NECHVÁTALOVÁ, Jana, Sophinus J. W. BARTOL, Zita CHOVANCOVÁ, Louis BOON, Marcela VLKOVÁ a Menno C. van ZELM. Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans. \textit{Journal of immunology}. Bethesda: American association of immunologists, 2018, roč.~201, č.~7, s.~1928-1935. ISSN~0022-1767. Dostupné z: https://dx.doi.org/10.4049/jimmunol.1800767.

Podrobný výpis o publikaci