Circadian rhythm of cardiac troponin I and its clinical impact
on the diagnostic accuracy for acute myocardial infarction

J 2018

Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction

WILDI, K., H. SINGEISEN, R. TWERENBOLD, P. BADERTSCHER, D. WUSSLER et. al.

Základní údaje

Originální název

Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction

Autoři

WILDI, K. (756 Švýcarsko), H. SINGEISEN (756 Švýcarsko), R. TWERENBOLD (756 Švýcarsko), P. BADERTSCHER (756 Švýcarsko), D. WUSSLER (756 Švýcarsko), L.J.J. KLINKENBERG (528 Nizozemské království), S.J.R. MEEX (528 Nizozemské království), T. NESTELBERGER (756 Švýcarsko), J. BOEDDINGHAUS (756 Švýcarsko), O. MIRO (724 Španělsko), F.J. MARTIN-SANCHEZ (724 Španělsko), B. MORAWIEC (616 Polsko), P. MUZYK (616 Polsko), Jiří PAŘENICA (203 Česká republika, domácí), D.I. KELLER (756 Švýcarsko), N. GEIGY (756 Švýcarsko), E. POTLUKOVA (756 Švýcarsko), Z. SABTI (756 Švýcarsko), N. KOZHUHAROV (756 Švýcarsko), C. PUELACHER (756 Švýcarsko), J.D. de LAVALLAZ (756 Švýcarsko), M.R. GIMENEZ (756 Švýcarsko), S. SHRESTHA (756 Švýcarsko), G. MARZANO (756 Švýcarsko), K. RENTSCH (756 Švýcarsko), S. OSSWALD (756 Švýcarsko), T. REICHLIN (756 Švýcarsko) a C. MUELLER (756 Švýcarsko, garant)

Vydání

International Journal of Cardiology, Clare, Elsevier Ireland Ltd. 2018, 0167-5273

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.471

Kód RIV

RIV/00216224:14110/18:00104226

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ijcard.2018.05.136

UT WoS

000444609000003

Klíčová slova anglicky

Acute myocardial infarction; Diagnosis; High-sensitivity cardiac troponin I; Circadian rhythm

Štítky

14110211, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 2. 2019 21:23, Soňa Böhmová

Anotace

V originále

Background: High-sensitivity cardiac troponin T (hs-cTnT) blood concentrationswere shown to exhibit a diurnal rhythm, characterized by gradually decreasing concentrations throughout daytime, rising concentrations during nighttime and peak concentrations in the morning. We aimed to investigate whether this also applies to (h)s-cTnI assays and whether it would affect diagnostic accuracy for acute myocardial infarction (AMI). Methods: Blood concentrations of cTnI were measured at presentation and after 1 h using four different cTnI assays: three commonly used sensitive (s-cTnI Architect, Ultra and Accu) and one experimental high-sensitivity assay (hs-cTnI Accu) in a prospective multicenter diagnostic study of patients presenting to the emergency department with suspected AMI. These concentrations and their diagnostic accuracy for AMI (quantified by the area under the curve (AUC)) were compared between morning (11 p.m. to 2 p.m.) and evening (2 p.m. to 11 p. m.) presenters. Results: Among 2601 patients, AMI was the final diagnosis in 17.6% of patients. Concentrations of (h) s-cTnI as measured using all four assayswere comparable in patients presenting in themorning versus patients presenting in the evening. Diagnostic accuracy for AMI of all four (h) s-cTnI assays were high and comparable between patients presenting in the morning versus presenting in the evening (AUC at presentation: 0.90 vs 0.93 for s-cTnI Architect; 0.91 vs 0.94 for s-cTnI Ultra; 0.89 vs 0.94 for s-cTnI Accu; 0.91 vs 0.94 for hs-cTnI Accu). Conclusions: Cardiac TnI does not seemto express a diurnal rhythm. Diagnostic accuracy for AMI is very high and does not differ with time of presentation. Clinical trial registration: NCT00470587, http://clinicaltrials.gov/show/NCT00470587 (c) 2018 Elsevier B.V. All rights reserved.

Citovat

WILDI, K., H. SINGEISEN, R. TWERENBOLD, P. BADERTSCHER, D. WUSSLER, L.J.J. KLINKENBERG, S.J.R. MEEX, T. NESTELBERGER, J. BOEDDINGHAUS, O. MIRO, F.J. MARTIN-SANCHEZ, B. MORAWIEC, P. MUZYK, Jiří PAŘENICA, D.I. KELLER, N. GEIGY, E. POTLUKOVA, Z. SABTI, N. KOZHUHAROV, C. PUELACHER, J.D. de LAVALLAZ, M.R. GIMENEZ, S. SHRESTHA, G. MARZANO, K. RENTSCH, S. OSSWALD, T. REICHLIN a C. MUELLER. Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction. International Journal of Cardiology. Clare: Elsevier Ireland Ltd., 2018, roč. 270, NOV 1 2018, s. 14-20. ISSN 0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2018.05.136.

@article{1456237,
   author = {Wildi, K. and Singeisen, H. and Twerenbold, R. and Badertscher, P. and Wussler, D. and Klinkenberg, L.J.J. and Meex, S.J.R. and Nestelberger, T. and Boeddinghaus, J. and Miro, O. and MartinandSanchez, F.J. and Morawiec, B. and Muzyk, P. and Pařenica, Jiří and Keller, D.I. and Geigy, N. and Potlukova, E. and Sabti, Z. and Kozhuharov, N. and Puelacher, C. and Lavallaz, J.D. de and Gimenez, M.R. and Shrestha, S. and Marzano, G. and Rentsch, K. and Osswald, S. and Reichlin, T. and Mueller, C.},
   article_location = {Clare},
   article_number = {NOV 1 2018},
   doi = {http://dx.doi.org/10.1016/j.ijcard.2018.05.136},
   keywords = {Acute myocardial infarction; Diagnosis; High-sensitivity cardiac troponin I; Circadian rhythm},
   language = {eng},
   issn = {0167-5273},
   journal = {International Journal of Cardiology},
   title = {Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction},
   volume = {270},
   year = {2018}
}

TY  - JOUR
ID  - 1456237
AU  - Wildi, K. - Singeisen, H. - Twerenbold, R. - Badertscher, P. - Wussler, D. - Klinkenberg, L.J.J. - Meex, S.J.R. - Nestelberger, T. - Boeddinghaus, J. - Miro, O. - Martin-Sanchez, F.J. - Morawiec, B. - Muzyk, P. - Pařenica, Jiří - Keller, D.I. - Geigy, N. - Potlukova, E. - Sabti, Z. - Kozhuharov, N. - Puelacher, C. - Lavallaz, J.D. de - Gimenez, M.R. - Shrestha, S. - Marzano, G. - Rentsch, K. - Osswald, S. - Reichlin, T. - Mueller, C.
PY  - 2018
TI  - Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction
JF  - International Journal of Cardiology
VL  - 270
IS  - NOV 1 2018
SP  - 14-20
EP  - 14-20
PB  - Elsevier Ireland Ltd.
SN  - 01675273
KW  - Acute myocardial infarction
KW  - Diagnosis
KW  - High-sensitivity cardiac troponin I
KW  - Circadian rhythm
N2  - Background: High-sensitivity cardiac troponin T (hs-cTnT) blood concentrationswere shown to exhibit a diurnal rhythm, characterized by gradually decreasing concentrations throughout daytime, rising concentrations during nighttime and peak concentrations in the morning. We aimed to investigate whether this also applies to (h)s-cTnI assays and whether it would affect diagnostic accuracy for acute myocardial infarction (AMI). Methods: Blood concentrations of cTnI were measured at presentation and after 1 h using four different cTnI assays: three commonly used sensitive (s-cTnI Architect, Ultra and Accu) and one experimental high-sensitivity assay (hs-cTnI Accu) in a prospective multicenter diagnostic study of patients presenting to the emergency department with suspected AMI. These concentrations and their diagnostic accuracy for AMI (quantified by the area under the curve (AUC)) were compared between morning (11 p.m. to 2 p.m.) and evening (2 p.m. to 11 p. m.) presenters. Results: Among 2601 patients, AMI was the final diagnosis in 17.6% of patients. Concentrations of (h) s-cTnI as measured using all four assayswere comparable in patients presenting in themorning versus patients presenting in the evening. Diagnostic accuracy for AMI of all four (h) s-cTnI assays were high and comparable between patients presenting in the morning versus presenting in the evening (AUC at presentation: 0.90 vs 0.93 for s-cTnI Architect; 0.91 vs 0.94 for s-cTnI Ultra; 0.89 vs 0.94 for s-cTnI Accu; 0.91 vs 0.94 for hs-cTnI Accu). Conclusions: Cardiac TnI does not seemto express a diurnal rhythm. Diagnostic accuracy for AMI is very high and does not differ with time of presentation. Clinical trial registration: NCT00470587, http://clinicaltrials.gov/show/NCT00470587 (c) 2018 Elsevier B.V. All rights reserved.
ER  -

WILDI, K., H. SINGEISEN, R. TWERENBOLD, P. BADERTSCHER, D. WUSSLER, L.J.J. KLINKENBERG, S.J.R. MEEX, T. NESTELBERGER, J. BOEDDINGHAUS, O. MIRO, F.J. MARTIN-SANCHEZ, B. MORAWIEC, P. MUZYK, Jiří PAŘENICA, D.I. KELLER, N. GEIGY, E. POTLUKOVA, Z. SABTI, N. KOZHUHAROV, C. PUELACHER, J.D. de LAVALLAZ, M.R. GIMENEZ, S. SHRESTHA, G. MARZANO, K. RENTSCH, S. OSSWALD, T. REICHLIN a C. MUELLER. Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction. \textit{International Journal of Cardiology}. Clare: Elsevier Ireland Ltd., 2018, roč.~270, NOV 1 2018, s.~14-20. ISSN~0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2018.05.136.

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