Hypersensitivity to material and environmental burden as a
possible cause of late complications of cardiac implantable
electronic devices

J 2018

Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices

MAŇOUSEK, Jan, Irena ANDRŠOVÁ, Vera STEJSKAL, Jitka VLAŠÍNOVÁ, Milan SEPŠI et. al.

Základní údaje

Originální název

Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices

Autoři

MAŇOUSEK, Jan (203 Česká republika), Irena ANDRŠOVÁ (203 Česká republika), Vera STEJSKAL (752 Švédsko, domácí), Jitka VLAŠÍNOVÁ (203 Česká republika), Milan SEPŠI (203 Česká republika, garant, domácí), Jan KUTA (203 Česká republika, domácí), Jana KLÁNOVÁ (203 Česká republika, domácí), Michal MAZÍK (703 Slovensko), Jiří JARKOVSKÝ (203 Česká republika, domácí), Lenka ŠNAJDROVÁ (203 Česká republika, domácí), Klára BENEŠOVÁ (203 Česká republika, domácí), Tomáš NOVOTNÝ (203 Česká republika), Andrea ZADÁKOVÁ (203 Česká republika) a Jindřich ŠPINAR (203 Česká republika)

Vydání

EP Europace, Oxford, Oxford University Press, 2018, 1099-5129

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 5.047

Kód RIV

RIV/00216224:14110/18:00104323

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1093/europace/eux227

UT WoS

000444551400003

Klíčová slova anglicky

Pacemaker; Implantable cardioverter-defibrillator; Late complication; Metal pollutants; Delayed-type hypersensitivity; Lymphocyte transformation test

Štítky

14110211, 14119612, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 3. 2019 10:48, Soňa Böhmová

Anotace

V originále

Aims To evaluate whether patients with late complications of pacemakers or implantable cardioverter-defibrillators have hypersensitivity reactions to some of the materials used in generators or in electrodes, or to environmental metal burden. Methods and results The cohort consisted of 20 men and 4 women (mean age: 62.3 +/- 17.2 years) who had a history of late complications of implanted devices. The control group involved 25 men and 8 women (mean age: 64.6 +/- 14.0 years) who had comparable devices, but no history of late complications. Lymphocyte transformation test was used to evaluate hypersensitivity to eight metal pollutants (antimony, manganese, mercury, molybdenum, nickel, platinum, tin, and titanium) selected by results of questionnaires on environmental burden, and by material analysis of generators and electrode surfaces. Exposures to metal pollutants were approximately the same in patients and in controls. Titanium alloy used in generators contained at least 99.32% of titanium and trace levels of other metals; higher levels of tin and platinum were detected in electrode surfaces. Hypersensitivity reactions to mercury and tin were significantly more frequent in patients than in controls (patients and controls: mercury: 68.2 and 31.1%, respectively; P = 0.022; tin: 25.0 and 3.2%, respectively; P = 0.035). In contrast, hypersensitivity to manganese was significantly more frequent in controls than in patients (patients and controls: 13.6 and 50.0%, respectively; P = 0.008). Conclusion Our findings suggest a possible relation between hypersensitivity to metals used in implantable devices or to environmental metal burden and the occurrence of their late complications.

Návaznosti

ED2.1.00/19.0382, projekt VaV

Název: CETOCOEN UPgrade

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

MAŇOUSEK, Jan, Irena ANDRŠOVÁ, Vera STEJSKAL, Jitka VLAŠÍNOVÁ, Milan SEPŠI, Jan KUTA, Jana KLÁNOVÁ, Michal MAZÍK, Jiří JARKOVSKÝ, Lenka ŠNAJDROVÁ, Klára BENEŠOVÁ, Tomáš NOVOTNÝ, Andrea ZADÁKOVÁ a Jindřich ŠPINAR. Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices. EP Europace. Oxford: Oxford University Press, 2018, roč. 20, č. 9, s. "E140"-"E147", 8 s. ISSN 1099-5129. Dostupné z: https://dx.doi.org/10.1093/europace/eux227.

@article{1461096,
   author = {Maňousek, Jan and Andršová, Irena and Stejskal, Vera and Vlašínová, Jitka and Sepši, Milan and Kuta, Jan and Klánová, Jana and Mazík, Michal and Jarkovský, Jiří and Šnajdrová, Lenka and Benešová, Klára and Novotný, Tomáš and Zadáková, Andrea and Špinar, Jindřich},
   article_location = {Oxford},
   article_number = {9},
   doi = {http://dx.doi.org/10.1093/europace/eux227},
   keywords = {Pacemaker; Implantable cardioverter-defibrillator; Late complication; Metal pollutants; Delayed-type hypersensitivity; Lymphocyte transformation test},
   language = {eng},
   issn = {1099-5129},
   journal = {EP Europace},
   title = {Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices},
   volume = {20},
   year = {2018}
}

TY  - JOUR
ID  - 1461096
AU  - Maňousek, Jan - Andršová, Irena - Stejskal, Vera - Vlašínová, Jitka - Sepši, Milan - Kuta, Jan - Klánová, Jana - Mazík, Michal - Jarkovský, Jiří - Šnajdrová, Lenka - Benešová, Klára - Novotný, Tomáš - Zadáková, Andrea - Špinar, Jindřich
PY  - 2018
TI  - Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices
JF  - EP Europace
VL  - 20
IS  - 9
SP  - "E140"-"E147"
EP  - "E140"-"E147"
PB  - Oxford University Press
SN  - 10995129
KW  - Pacemaker
KW  - Implantable cardioverter-defibrillator
KW  - Late complication
KW  - Metal pollutants
KW  - Delayed-type hypersensitivity
KW  - Lymphocyte transformation test
N2  - Aims To evaluate whether patients with late complications of pacemakers or implantable cardioverter-defibrillators have hypersensitivity reactions to some of the materials used in generators or in electrodes, or to environmental metal burden. Methods and results The cohort consisted of 20 men and 4 women (mean age: 62.3 +/- 17.2 years) who had a history of late complications of implanted devices. The control group involved 25 men and 8 women (mean age: 64.6 +/- 14.0 years) who had comparable devices, but no history of late complications. Lymphocyte transformation test was used to evaluate hypersensitivity to eight metal pollutants (antimony, manganese, mercury, molybdenum, nickel, platinum, tin, and titanium) selected by results of questionnaires on environmental burden, and by material analysis of generators and electrode surfaces. Exposures to metal pollutants were approximately the same in patients and in controls. Titanium alloy used in generators contained at least 99.32% of titanium and trace levels of other metals; higher levels of tin and platinum were detected in electrode surfaces. Hypersensitivity reactions to mercury and tin were significantly more frequent in patients than in controls (patients and controls: mercury: 68.2 and 31.1%, respectively; P = 0.022; tin: 25.0 and 3.2%, respectively; P = 0.035). In contrast, hypersensitivity to manganese was significantly more frequent in controls than in patients (patients and controls: 13.6 and 50.0%, respectively; P = 0.008). Conclusion Our findings suggest a possible relation between hypersensitivity to metals used in implantable devices or to environmental metal burden and the occurrence of their late complications.
ER  -

MAŇOUSEK, Jan, Irena ANDRŠOVÁ, Vera STEJSKAL, Jitka VLAŠÍNOVÁ, Milan SEPŠI, Jan KUTA, Jana KLÁNOVÁ, Michal MAZÍK, Jiří JARKOVSKÝ, Lenka ŠNAJDROVÁ, Klára BENEŠOVÁ, Tomáš NOVOTNÝ, Andrea ZADÁKOVÁ a Jindřich ŠPINAR. Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices. \textit{EP Europace}. Oxford: Oxford University Press, 2018, roč.~20, č.~9, s.~''E140''-''E147'', 8 s. ISSN~1099-5129. Dostupné z: https://dx.doi.org/10.1093/europace/eux227.

Podrobný výpis o publikaci