Differences in Interleukin-8 Plasma Levels between Diabetic
Patients and Healthy Individuals Independently on Their
Periodontal Status

J 2018

Differences in Interleukin-8 Plasma Levels between Diabetic Patients and Healthy Individuals Independently on Their Periodontal Status

BOŘILOVÁ LINHARTOVÁ, Petra, Denisa KAVŘÍKOVÁ, Marie TOMANDLOVÁ, Hana POSKEROVÁ, Václav ŘEHKA et. al.

Základní údaje

Originální název

Differences in Interleukin-8 Plasma Levels between Diabetic Patients and Healthy Individuals Independently on Their Periodontal Status

Autoři

BOŘILOVÁ LINHARTOVÁ, Petra (203 Česká republika, domácí), Denisa KAVŘÍKOVÁ (203 Česká republika, domácí), Marie TOMANDLOVÁ (203 Česká republika, domácí), Hana POSKEROVÁ (203 Česká republika, domácí), Václav ŘEHKA (203 Česká republika, domácí), Ladislav DUŠEK (203 Česká republika, domácí) a Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika, garant, domácí)

Vydání

International Journal of Molecular Sciences, Basel, Switzerland, MDPI AG, 2018, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.183

Kód RIV

RIV/00216224:14110/18:00101349

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/ijms19103214

UT WoS

000448951000369

Klíčová slova anglicky

interleukin-8; chemokines; plasma; polymorphism; chronic periodontitis; diabetes mellitus

Štítky

14110130, 14110512, 14110518, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 2. 2019 22:11, Soňa Böhmová

Anotace

V originále

Chronic periodontitis (CP) and diabetes mellitus (DM) involve several aspects of immune functions, including neutrophil activity and cytokine biology. Considering the critical function of chemokine interleukin-8 (IL-8) in the inflammatory process, the aims of this study were to determine: (i) IL-8 plasma levels; (ii) IL-8 (-251A/T, rs4073) and its receptor 2 (CXCR2, +1208C/T, rs1126579) polymorphisms, and (iii) the presence of the selected periodontal bacteria in types 1 and 2 DM patients (T1DM and T2DM) and systemically healthy controls (HC) with known periodontal status. This case-control study comprises of 153 unrelated individuals: 36/44 patients suffering from T1DM+CP/T2DM+CP and 32/41 from HC+CP/non-periodontitis HC. Both the clinical and biochemical parameters were monitored. The genotypes were determined using qPCR, IL-8 plasma levels were measured using an ELISA kit. Subgingival bacterial colonization was analyzed with a DNA microarray detection kit. The IL-8 plasma levels differed significantly between non-periodontitis HC and T1DM+CP/T2DM+CP patients (P < 0.01). Even in HC+CP, IL-8 concentrations were significantly lower than in T1DM+CP/T2DM+CP patients (P 0.05). No significant associations between the IL-8 plasma levels and the studied IL-8 and CXCR2 polymorphisms or the occurrence of selected periodontal bacteria (P > 0.05) were found. CP does not influence the circulating IL-8 levels. Patients with T1DM+CP/T2DM+CP had higher circulating IL-8 levels than HC+CP/non-periodontitis HC.

Návaznosti

GB14-37368G, projekt VaV

Název: Centrum orofaciálního vývoje a regenerace

Investor: Grantová agentura ČR, Centrum orofaciálního vývoje a regenerace

MUNI/A/1008/2017, interní kód MU

Název: Etiopatogenetické aspekty, diagnostika a léčba vybraných onemocnění dutiny ústní

Investor: Masarykova univerzita, Etiopatogenetické aspekty, diagnostika a léčba vybraných onemocnění dutiny ústní, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

ROZV/25/LF/2017, interní kód MU

Název: LF - Příspěvek na IP 2017

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek na IP 2017, Interní rozvojové projekty

Citovat

BOŘILOVÁ LINHARTOVÁ, Petra, Denisa KAVŘÍKOVÁ, Marie TOMANDLOVÁ, Hana POSKEROVÁ, Václav ŘEHKA, Ladislav DUŠEK a Lydie IZAKOVIČOVÁ HOLLÁ. Differences in Interleukin-8 Plasma Levels between Diabetic Patients and Healthy Individuals Independently on Their Periodontal Status. International Journal of Molecular Sciences. Basel, Switzerland: MDPI AG, 2018, roč. 19, č. 10, s. 1-17. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19103214.

@article{1468996,
   author = {Bořilová Linhartová, Petra and Kavříková, Denisa and Tomandlová, Marie and Poskerová, Hana and Řehka, Václav and Dušek, Ladislav and Izakovičová Hollá, Lydie},
   article_location = {Basel, Switzerland},
   article_number = {10},
   doi = {http://dx.doi.org/10.3390/ijms19103214},
   keywords = {interleukin-8; chemokines; plasma; polymorphism; chronic periodontitis; diabetes mellitus},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Differences in Interleukin-8 Plasma Levels between Diabetic Patients and Healthy Individuals Independently on Their Periodontal Status},
   volume = {19},
   year = {2018}
}

TY  - JOUR
ID  - 1468996
AU  - Bořilová Linhartová, Petra - Kavříková, Denisa - Tomandlová, Marie - Poskerová, Hana - Řehka, Václav - Dušek, Ladislav - Izakovičová Hollá, Lydie
PY  - 2018
TI  - Differences in Interleukin-8 Plasma Levels between Diabetic Patients and Healthy Individuals Independently on Their Periodontal Status
JF  - International Journal of Molecular Sciences
VL  - 19
IS  - 10
SP  - 1-17
EP  - 1-17
PB  - MDPI AG
SN  - 14220067
KW  - interleukin-8
KW  - chemokines
KW  - plasma
KW  - polymorphism
KW  - chronic periodontitis
KW  - diabetes mellitus
N2  - Chronic periodontitis (CP) and diabetes mellitus (DM) involve several aspects of immune functions, including neutrophil activity and cytokine biology. Considering the critical function of chemokine interleukin-8 (IL-8) in the inflammatory process, the aims of this study were to determine: (i) IL-8 plasma levels; (ii) IL-8 (-251A/T, rs4073) and its receptor 2 (CXCR2, +1208C/T, rs1126579) polymorphisms, and (iii) the presence of the selected periodontal bacteria in types 1 and 2 DM patients (T1DM and T2DM) and systemically healthy controls (HC) with known periodontal status. This case-control study comprises of 153 unrelated individuals: 36/44 patients suffering from T1DM+CP/T2DM+CP and 32/41 from HC+CP/non-periodontitis HC. Both the clinical and biochemical parameters were monitored. The genotypes were determined using qPCR, IL-8 plasma levels were measured using an ELISA kit. Subgingival bacterial colonization was analyzed with a DNA microarray detection kit. The IL-8 plasma levels differed significantly between non-periodontitis HC and T1DM+CP/T2DM+CP patients (P < 0.01). Even in HC+CP, IL-8 concentrations were significantly lower than in T1DM+CP/T2DM+CP patients (P 0.05). No significant associations between the IL-8 plasma levels and the studied IL-8 and CXCR2 polymorphisms or the occurrence of selected periodontal bacteria (P > 0.05) were found. CP does not influence the circulating IL-8 levels. Patients with T1DM+CP/T2DM+CP had higher circulating IL-8 levels than HC+CP/non-periodontitis HC.
ER  -

BOŘILOVÁ LINHARTOVÁ, Petra, Denisa KAVŘÍKOVÁ, Marie TOMANDLOVÁ, Hana POSKEROVÁ, Václav ŘEHKA, Ladislav DUŠEK a Lydie IZAKOVIČOVÁ HOLLÁ. Differences in Interleukin-8 Plasma Levels between Diabetic Patients and Healthy Individuals Independently on Their Periodontal Status. \textit{International Journal of Molecular Sciences}. Basel, Switzerland: MDPI AG, 2018, roč.~19, č.~10, s.~1-17. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19103214.

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