Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ, Pavel KUKLÍNEK, Antonín FASSMANN and Lydie IZAKOVIČOVÁ HOLLÁ. Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis. In XIX. setkání biochemiků a molekulárních biologů, Brno. 2018.

Basic information

• Original name: Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis
• Authors: SLEZÁKOVÁ, Simona (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Jiřina BÁRTOVÁ (203 Czech Republic), Jitka PETANOVÁ (203 Czech Republic), Pavel KUKLÍNEK (203 Czech Republic, belonging to the institution), Antonín FASSMANN (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: XIX. setkání biochemiků a molekulárních biologů, Brno, 2018.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30208 Dentistry, oral surgery and medicine
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/18:00101355
• Organization unit: Faculty of Medicine
• Keywords in English: serotonin transporter gene; polymorphism; recurrent aphthous stomatitis

Abstract

Background: Recurrent aphthous stomatitis (RAS) is a common chronic inflammatory disease of oral mucosa characterized by single or multiple painful erosions and ulcers. The etiopathogenesis of RAS has not been elucidated yet, but anxiety and stress are considered as one of the main factors influencing the manifestation of RAS. Variability in serotonin transporter gene (SLC6A4), modulating the magnitude and duration of serotonergic neurotransmission, has been previously associated with RAS. The aim of our study was to analyse five polymorphisms in the SLC6A4 gene in patients with RAS and healthy controls. Subjects and methods: Totally, 239 subjects were enrolled in this case-control study: 86 patients with RAS and 153 healthy individuals. The serotonin transporter length polymorphic region (5-HTTLPR) polymorphism, variable number tandem repeat (STin2) and single nucleotide polymorphisms (rs25531, rs1042173, rs3813034) in the SLC6A4 gene were determined by polymerase chain reaction with/without restriction analysis. Results: The allele, genotype and haplotype frequencies of all five studied polymorphisms between RAS patients and healthy controls were similar (P>0.05). Nevertheless, the distribution of allele frequencies of 5-HTTLPR SLC6A4 polymorphism was marginally different between patients with RAS and healthy controls (P=0.07). Conclusions: In contrast to previous studies in Brazilian and Iranian populations, our study did not confirm the association between the SLC6A4 gene variability and susceptibility to RAS.

Links

• GB14-37368G, research and development project: Name: Centrum orofaciálního vývoje a regenerace

Investor: Czech Science Foundation

• MUNI/A/1008/2017, interní kód MU: Name: Etiopatogenetické aspekty, diagnostika a léčba vybraných onemocnění dutiny ústní

Investor: Masaryk University, Category A

• NV15-29336A, research and development project: Name: Změny imunologické reaktivity u pacientů s recidivujícími aftami
• ROZV/24/LF/2018, interní kód MU: Name: LF - Příspěvek na IP 2108

Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects