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@proceedings{1470698,
author = {Beneš, Petr and Šmarda, Jan and Knopfová, Lucia},
booktitle = {XIX. setkání biochemiků a molekulárních biologů, 13.-14. 11. 2018, Brno},
isbn = {978-80-210-9069-9},
title = {Could overexpression of an ONCOGENE represent a good prognostic factor in cancer?},
year = {2018}
}
TY - CONF
ID - 1470698
AU - Beneš, Petr - Šmarda, Jan - Knopfová, Lucia
PY - 2018
TI - Could overexpression of an ONCOGENE represent a good prognostic factor in cancer?
SN - 9788021090699
N2 - The c-Myb protein is a transcriptional regulator of stem cells maintenance in bone marrow, colon epithelia, and brain neurogenic niches. The pioneering research revealed that c-Myb is essential for normal hematopoiesis and identified it as important oncogene in various leukemias. The mechanism of its oncogenic function has been intensively studied in last decades and c-Myb is currently considered as a key regulator of balance between cell proliferation, differentiation and survival. Later studies found c-Myb overexpression in many carcinomas where its oncogenic function has been confirmed as well. Interestingly, we and others have recently shown that increased expression of c-Myb protein represents a good prognostic factor in breast and colon carcinomas. Our current research therefore aims to clarify this unusual phenomenon.
ER -
BENEŠ, Petr, Jan ŠMARDA a Lucia KNOPFOVÁ. Could overexpression of an ONCOGENE represent a good prognostic factor in cancer? In \textit{XIX. setkání biochemiků a molekulárních biologů, 13.-14. 11. 2018, Brno}. 2018. ISBN~978-80-210-9069-9.
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