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@proceedings{1470700,
author = {Friedlová, Nela and Dúcka, Monika and Beneš, Petr and Knopfová, Lucia},
booktitle = {Molecular Patholology Days, 14.-15. 6. 2018, Olomouc.},
isbn = {978-80-7471-234-0},
title = {Inflammatory cues induce expression of immune checkpoint molecule CD137 in breast cancer cells},
year = {2018}
}
TY - CONF
ID - 1470700
AU - Friedlová, Nela - Dúcka, Monika - Beneš, Petr - Knopfová, Lucia
PY - 2018
TI - Inflammatory cues induce expression of immune checkpoint molecule CD137 in breast cancer cells
SN - 9788074712340
N2 - CD137 (Tumor Necrosis Factor Receptor Superfamily, Member 9) was originally described as a T cell co-stimulatory molecule. In context of cancer it is a valuable target for immunotherapy, as the agonist CD137 antibodies induce potent T cell-mediated anti-tumor immunity. However, tumor cells utilize CD137-based strategies, such as expression of its soluble variant, in order to prevent co-stimulation of T lymphocytes. Besides, immune checkpoint molecules have been shown to promote the epithelial-mesenchymal transition, the acquisition of tumor-initiating potential and resistance to apoptosis and antitumor drugs, as well as the propensity to disseminate and metastasize. Autocrine and paracrine effects of CD137 receptor/ligand bidirectional signaling in breast cancer are still only marginally understood. We have recently described that CD137 expression is downregulated by metastasis suppressor c-Myb in mammary cancer cells. On contrary, its expression is induced by inflammatory stimuli, such as TNF. We explore how tumor-derived CD137 affects breast cancer biology and interactions with immune/stromal cells.
ER -
FRIEDLOVÁ, Nela, Monika DÚCKA, Petr BENEŠ a Lucia KNOPFOVÁ. Inflammatory cues induce expression of immune checkpoint molecule CD137 in breast cancer cells. In \textit{Molecular Patholology Days, 14.-15. 6. 2018, Olomouc.}. 2018. ISBN~978-80-7471-234-0.
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