Recurrent aphthous stomatitis and gene variability in selected
interleukins: a case-control study

J 2018

Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study

BOŘILOVÁ LINHARTOVÁ, Petra, Július JÁNOŠ, Simona SLEZÁKOVÁ, Jirina BARTOVA, Jitka PETANOVA et. al.

Základní údaje

Originální název

Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study

Autoři

BOŘILOVÁ LINHARTOVÁ, Petra (203 Česká republika, domácí), Július JÁNOŠ (703 Slovensko, domácí), Simona SLEZÁKOVÁ (203 Česká republika, domácí), Jirina BARTOVA (203 Česká republika), Jitka PETANOVA (203 Česká republika), Pavel KUKLÍNEK (203 Česká republika, domácí), Antonín FASSMANN (203 Česká republika, domácí), Ladislav DUŠEK (203 Česká republika, domácí) a Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika, garant, domácí)

Vydání

EUROPEAN JOURNAL OF ORAL SCIENCES, HOBOKEN, WILEY-BLACKWELL, 2018, 0909-8836

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.810

Kód RIV

RIV/00216224:14110/18:00101375

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/eos.12577

UT WoS

000449881600006

Klíčová slova anglicky

association studies; candidate gene; genetic; immunity; oral ulcer; polymorphisms

Štítky

14110114, 14110130, 14110518, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 2. 2019 18:59, Soňa Böhmová

Anotace

V originále

Genetic factors, especially those related to immune system functioning, have been intensively studied to determine their role in the development of recurrent aphthous stomatitis (RAS). The aim of the present study was to analyze gene variability in interleukin (IL)2, IL4 (and its receptor alpha, IL4R alpha), IL10, and IL13, which were selected based on literature review and/or their functional relevance, in Czech patients with RAS and in healthy controls. In total, 252 subjects (178 controls and 74 patients with RAS) were enrolled in this case-control study, and their detailed anamnestic, clinical, and laboratory data were obtained. Nine polymorphisms in the genes encoding interleukins were determined using PCR techniques. There were no significant differences in allele or genotype frequencies of the IL2, IL4, IL4R alpha, IL10, and IL13 polymorphisms rs2069762/rs2069763, rs2243250/rs79071878, rs1801275, rs1800896, and rs1800925, respectively, between controls and patients with RAS. The minority alleles rs1800871 and rs1800872, which encode variants of IL10, were associated with a statistically significantly higher risk of RAS, as confirmed by the results of genotype and haplotype analyses. We suggest that variability in the IL10 gene may play an important role in the development of RAS in the Czech population.

Návaznosti

GB14-37368G, projekt VaV

Název: Centrum orofaciálního vývoje a regenerace

Investor: Grantová agentura ČR, Centrum orofaciálního vývoje a regenerace

MUNI/A/1008/2017, interní kód MU

Název: Etiopatogenetické aspekty, diagnostika a léčba vybraných onemocnění dutiny ústní

Investor: Masarykova univerzita, Etiopatogenetické aspekty, diagnostika a léčba vybraných onemocnění dutiny ústní, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

NV15-29336A, projekt VaV

Název: Změny imunologické reaktivity u pacientů s recidivujícími aftami

ROZV/24/LF/2018, interní kód MU

Název: LF - Příspěvek na IP 2108

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek na IP 2108, Interní rozvojové projekty

Citovat

BOŘILOVÁ LINHARTOVÁ, Petra, Július JÁNOŠ, Simona SLEZÁKOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLÍNEK, Antonín FASSMANN, Ladislav DUŠEK a Lydie IZAKOVIČOVÁ HOLLÁ. Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study. EUROPEAN JOURNAL OF ORAL SCIENCES. HOBOKEN: WILEY-BLACKWELL, 2018, roč. 126, č. 6, s. 485-492. ISSN 0909-8836. Dostupné z: https://dx.doi.org/10.1111/eos.12577.

@article{1472316,
   author = {Bořilová Linhartová, Petra and Jánoš, Július and Slezáková, Simona and Bartova, Jirina and Petanova, Jitka and Kuklínek, Pavel and Fassmann, Antonín and Dušek, Ladislav and Izakovičová Hollá, Lydie},
   article_location = {HOBOKEN},
   article_number = {6},
   doi = {http://dx.doi.org/10.1111/eos.12577},
   keywords = {association studies; candidate gene; genetic; immunity; oral ulcer; polymorphisms},
   language = {eng},
   issn = {0909-8836},
   journal = {EUROPEAN JOURNAL OF ORAL SCIENCES},
   title = {Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study},
   volume = {126},
   year = {2018}
}

TY  - JOUR
ID  - 1472316
AU  - Bořilová Linhartová, Petra - Jánoš, Július - Slezáková, Simona - Bartova, Jirina - Petanova, Jitka - Kuklínek, Pavel - Fassmann, Antonín - Dušek, Ladislav - Izakovičová Hollá, Lydie
PY  - 2018
TI  - Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study
JF  - EUROPEAN JOURNAL OF ORAL SCIENCES
VL  - 126
IS  - 6
SP  - 485-492
EP  - 485-492
PB  - WILEY-BLACKWELL
SN  - 09098836
KW  - association studies
KW  - candidate gene
KW  - genetic
KW  - immunity
KW  - oral ulcer
KW  - polymorphisms
N2  - Genetic factors, especially those related to immune system functioning, have been intensively studied to determine their role in the development of recurrent aphthous stomatitis (RAS). The aim of the present study was to analyze gene variability in interleukin (IL)2, IL4 (and its receptor alpha, IL4R alpha), IL10, and IL13, which were selected based on literature review and/or their functional relevance, in Czech patients with RAS and in healthy controls. In total, 252 subjects (178 controls and 74 patients with RAS) were enrolled in this case-control study, and their detailed anamnestic, clinical, and laboratory data were obtained. Nine polymorphisms in the genes encoding interleukins were determined using PCR techniques. There were no significant differences in allele or genotype frequencies of the IL2, IL4, IL4R alpha, IL10, and IL13 polymorphisms rs2069762/rs2069763, rs2243250/rs79071878, rs1801275, rs1800896, and rs1800925, respectively, between controls and patients with RAS. The minority alleles rs1800871 and rs1800872, which encode variants of IL10, were associated with a statistically significantly higher risk of RAS, as confirmed by the results of genotype and haplotype analyses. We suggest that variability in the IL10 gene may play an important role in the development of RAS in the Czech population.
ER  -

BOŘILOVÁ LINHARTOVÁ, Petra, Július JÁNOŠ, Simona SLEZÁKOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLÍNEK, Antonín FASSMANN, Ladislav DUŠEK a Lydie IZAKOVIČOVÁ HOLLÁ. Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study. \textit{EUROPEAN JOURNAL OF ORAL SCIENCES}. HOBOKEN: WILEY-BLACKWELL, 2018, roč.~126, č.~6, s.~485-492. ISSN~0909-8836. Dostupné z: https://dx.doi.org/10.1111/eos.12577.

Podrobný výpis o publikaci