Trop2 inhibits proliferation and promotes cell survival in low
serum conditions in breast cancer cells

k 2018

Trop2 inhibits proliferation and promotes cell survival in low serum conditions in breast cancer cells

LENÁRT, Sára, Tereza KUČÍRKOVÁ, Filip TRČKA, Ján REMŠÍK, Karel SOUČEK et. al.

Základní údaje

Originální název

Trop2 inhibits proliferation and promotes cell survival in low serum conditions in breast cancer cells

Autoři

LENÁRT, Sára, Tereza KUČÍRKOVÁ, Filip TRČKA, Ján REMŠÍK, Karel SOUČEK, Jan ŠMARDA a Petr BENEŠ

Vydání

XIX. setkání biochemiků a molekulárních biologů, 2018

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Přírodovědecká fakulta

ISBN

978-80-210-9069-9

Změněno: 29. 11. 2018 14:41, Mgr. Sára Lenárt, Ph.D.

Anotace

V originále

Carcinomas account for 80-90% of all tumors. Trop2 is transmembrane glycoprotein commonly overexpressed in carcinomas where its expression often correlates with tumor aggressiveness, metastases, and poor prognosis. Trop2 is therefore considered as suitable antigen for targeted therapy. Interestingly, our knowledge about molecular mechanisms of Trop2 action in cancer cells is limited. Using overexpression of wt and mutant Trop2 proteins, we have investigated the role of Trop2 in cell response to stress in MDA-MB-231 breast cancer cell line. Our data show that cells overexpressing Trop2 are more resistant to starvation that corresponds to their lower proliferation activity and activation of Akt kinase. Moreover, we found that Akt activation depends on Trop2 regulated intramembrane proteolysis. Our findings provide a novel insight into Trop2 signaling and function in cancer cells with potential implications for future research and therapies. This work was supported by the projects no. LQ1605 from the National Program of Sustainability II (MEYS Czech Republic), and MUNI/A/0824/2017 from Grant Agency of the Masaryk University.

Citovat

LENÁRT, Sára, Tereza KUČÍRKOVÁ, Filip TRČKA, Ján REMŠÍK, Karel SOUČEK, Jan ŠMARDA a Petr BENEŠ. Trop2 inhibits proliferation and promotes cell survival in low serum conditions in breast cancer cells. In XIX. setkání biochemiků a molekulárních biologů. 2018. ISBN 978-80-210-9069-9.

@proceedings{1473257,
   author = {Lenárt, Sára and Kučírková, Tereza and Trčka, Filip and Remšík, Ján and Souček, Karel and Šmarda, Jan and Beneš, Petr},
   booktitle = {XIX. setkání biochemiků a molekulárních biologů},
   language = {eng},
   isbn = {978-80-210-9069-9},
   title = {Trop2 inhibits proliferation and promotes cell survival in low serum conditions in breast cancer cells},
   year = {2018}
}

TY  - CONF
ID  - 1473257
AU  - Lenárt, Sára - Kučírková, Tereza - Trčka, Filip - Remšík, Ján - Souček, Karel - Šmarda, Jan - Beneš, Petr
PY  - 2018
TI  - Trop2 inhibits proliferation and promotes cell survival in low serum conditions in breast cancer cells
SN  - 9788021090699
N2  - Carcinomas account for 80-90% of all tumors. Trop2 is transmembrane glycoprotein commonly overexpressed in carcinomas where its expression often correlates with tumor aggressiveness, metastases, and poor prognosis. Trop2 is therefore considered as suitable antigen for targeted therapy. Interestingly, our knowledge about molecular mechanisms of Trop2 action in cancer cells is limited. Using overexpression of wt and mutant Trop2 proteins, we have investigated the role of Trop2 in cell response to stress in MDA-MB-231 breast cancer cell line. Our data show that cells overexpressing Trop2 are more resistant to starvation that corresponds to their lower proliferation activity and activation of Akt kinase. Moreover, we found that Akt activation depends on Trop2 regulated intramembrane proteolysis. Our findings provide a novel insight into Trop2 signaling and function in cancer cells with potential implications for future research and therapies. This work was supported by the projects no. LQ1605 from the National Program of Sustainability II (MEYS Czech Republic), and MUNI/A/0824/2017 from Grant Agency of the Masaryk University.
ER  -

LENÁRT, Sára, Tereza KUČÍRKOVÁ, Filip TRČKA, Ján REMŠÍK, Karel SOUČEK, Jan ŠMARDA a Petr BENEŠ. Trop2 inhibits proliferation and promotes cell survival in low serum conditions in breast cancer cells. In \textit{XIX. setkání biochemiků a molekulárních biologů}. 2018. ISBN~978-80-210-9069-9.

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