Complement activation is associated with more severe course of
diarrhea-associated hemolytic uremic syndrome, a preliminary
study

J 2018

Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study

KARNISOVA, Lucia, Ondrej HRADSKY, Kveta BLAHOVA, Filip FENCL, Zdeněk DOLEŽEL et. al.

Základní údaje

Originální název

Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study

Autoři

KARNISOVA, Lucia (203 Česká republika, garant), Ondrej HRADSKY (203 Česká republika), Kveta BLAHOVA (203 Česká republika), Filip FENCL (203 Česká republika), Zdeněk DOLEŽEL (203 Česká republika, domácí), Tomas ZAORAL (203 Česká republika) a Jakub ZIEG (203 Česká republika)

Vydání

European journal of pediatrics, New York, Springer, 2018, 0340-6199

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30209 Paediatrics

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.188

Kód RIV

RIV/00216224:14110/18:00104709

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s00431-018-3255-2

UT WoS

000450003400013

Klíčová slova anglicky

Complement; Hemolytic uremic syndrome; Shiga toxin-producing Escherichia coli; Renal replacement therapy

Štítky

14110317, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 2. 2019 21:53, Soňa Böhmová

Anotace

V originále

Diarrhea-associated hemolytic uremic syndrome is characterized by hemolytic anemia, thrombocytopenia, and acute kidney injury secondary to enteric infection, typically Shiga toxin-producing Escherichia coli. Shiga toxin 2 is able to activate alternative complement pathways; therefore, the aim of the study was to analyze C3 as a predictor of clinical courses in patients with diarrhea-associated hemolytic uremic syndrome. We hypothesized that the patients with increased complement activation at admission suffered from a more severe course. We retrospectively analyzed data of 33 pediatric patients between 1999 and 2015 in the Czech Republic. We tested the association of a C3 concentration with biochemical parameters and the clinical data reflecting the severity of the disease. We found significant correlation between the initial C3 and the duration of renal replacement therapy (r=-0.62, p=0.0001) and the initial glomerular filtration rate (r=0.36, p=0.026). Patients with C3<0.825g/L needed renal replacement therapy and also had significantly more renal complications (p=0.015).Conclusion: Based on our study, decreased C3 concentrations can be used as one of the risk factors that can help predict the need for acute dialysis and a more severe course of disease in children with diarrhea-associated hemolytic uremic syndrome.

Citovat

KARNISOVA, Lucia, Ondrej HRADSKY, Kveta BLAHOVA, Filip FENCL, Zdeněk DOLEŽEL, Tomas ZAORAL a Jakub ZIEG. Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study. European journal of pediatrics. New York: Springer, 2018, roč. 177, č. 12, s. 1837-1844. ISSN 0340-6199. Dostupné z: https://dx.doi.org/10.1007/s00431-018-3255-2.

@article{1473308,
   author = {Karnisova, Lucia and Hradsky, Ondrej and Blahova, Kveta and Fencl, Filip and Doležel, Zdeněk and Zaoral, Tomas and Zieg, Jakub},
   article_location = {New York},
   article_number = {12},
   doi = {http://dx.doi.org/10.1007/s00431-018-3255-2},
   keywords = {Complement; Hemolytic uremic syndrome; Shiga toxin-producing Escherichia coli; Renal replacement therapy},
   language = {eng},
   issn = {0340-6199},
   journal = {European journal of pediatrics},
   title = {Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study},
   volume = {177},
   year = {2018}
}

TY  - JOUR
ID  - 1473308
AU  - Karnisova, Lucia - Hradsky, Ondrej - Blahova, Kveta - Fencl, Filip - Doležel, Zdeněk - Zaoral, Tomas - Zieg, Jakub
PY  - 2018
TI  - Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study
JF  - European journal of pediatrics
VL  - 177
IS  - 12
SP  - 1837-1844
EP  - 1837-1844
PB  - Springer
SN  - 03406199
KW  - Complement
KW  - Hemolytic uremic syndrome
KW  - Shiga toxin-producing Escherichia coli
KW  - Renal replacement therapy
N2  - Diarrhea-associated hemolytic uremic syndrome is characterized by hemolytic anemia, thrombocytopenia, and acute kidney injury secondary to enteric infection, typically Shiga toxin-producing Escherichia coli. Shiga toxin 2 is able to activate alternative complement pathways; therefore, the aim of the study was to analyze C3 as a predictor of clinical courses in patients with diarrhea-associated hemolytic uremic syndrome. We hypothesized that the patients with increased complement activation at admission suffered from a more severe course. We retrospectively analyzed data of 33 pediatric patients between 1999 and 2015 in the Czech Republic. We tested the association of a C3 concentration with biochemical parameters and the clinical data reflecting the severity of the disease. We found significant correlation between the initial C3 and the duration of renal replacement therapy (r=-0.62, p=0.0001) and the initial glomerular filtration rate (r=0.36, p=0.026). Patients with C3<0.825g/L needed renal replacement therapy and also had significantly more renal complications (p=0.015).Conclusion: Based on our study, decreased C3 concentrations can be used as one of the risk factors that can help predict the need for acute dialysis and a more severe course of disease in children with diarrhea-associated hemolytic uremic syndrome.
ER  -

KARNISOVA, Lucia, Ondrej HRADSKY, Kveta BLAHOVA, Filip FENCL, Zdeněk DOLEŽEL, Tomas ZAORAL a Jakub ZIEG. Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study. \textit{European journal of pediatrics}. New York: Springer, 2018, roč.~177, č.~12, s.~1837-1844. ISSN~0340-6199. Dostupné z: https://dx.doi.org/10.1007/s00431-018-3255-2.

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