Visible-light-activated photoCORMs: rational design of
CO-releasing organic molecules absorbing in the
tissue-transparent window

J 2018

Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window

SLANINA, Tomáš a Peter ŠEBEJ

Základní údaje

Originální název

Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window

Autoři

SLANINA, Tomáš (203 Česká republika) a Peter ŠEBEJ (703 Slovensko, garant, domácí)

Vydání

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, CAMBRIDGE, ROYAL SOC CHEMISTRY, 2018, 1474-905X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10403 Physical chemistry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.408

Kód RIV

RIV/00216224:14310/18:00104735

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1039/c8pp00096d

UT WoS

000435358900001

Klíčová slova anglicky

PHOTOREMOVABLE PROTECTING GROUPS; METAL-CARBONYL-COMPLEXES; PROTEIN-KINASE PATHWAY; LIVING CELLS; NITRIC-OXIDE; AQUEOUS-SOLUTION; NIR LIGHT; IN-VIVO; STRUCTURAL-CHARACTERIZATION; XANTHENE-9-CARBOXYLIC ACID

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 11. 2018 21:37, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

To date, most known molecules that release carbon monoxide by the action of light are based on carbonyl complexes of metals. However, they suffer from several disadvantages, so the focus of this perspective is on photoactivatable metal-free CO precursors. The development and design of these systems from the starting point of deep-UV-absorbing hydrophobic molecules and leading to hydrophilic biocompatible visible-light-absorbing CO-releasing molecules (photoCORMs) is described with mechanistic details for several structural motifs. The possibilities of this development are not exhausted and here we discuss the design of new biologically interesting candidates.

Návaznosti

CZ.02.1.01/0.0/0.0/16_013/0001761, interní kód MU

Název: RECETOX RI - OP VVV (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI - OP VVV, PO 1 Posilování kapacit pro kvalitní výzkum

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

SLANINA, Tomáš a Peter ŠEBEJ. Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2018, roč. 17, č. 6, s. 692-710. ISSN 1474-905X. Dostupné z: https://dx.doi.org/10.1039/c8pp00096d.

@article{1473623,
   author = {Slanina, Tomáš and Šebej, Peter},
   article_location = {CAMBRIDGE},
   article_number = {6},
   doi = {http://dx.doi.org/10.1039/c8pp00096d},
   keywords = {PHOTOREMOVABLE PROTECTING GROUPS; METAL-CARBONYL-COMPLEXES; PROTEIN-KINASE PATHWAY; LIVING CELLS; NITRIC-OXIDE; AQUEOUS-SOLUTION; NIR LIGHT; IN-VIVO; STRUCTURAL-CHARACTERIZATION; XANTHENE-9-CARBOXYLIC ACID},
   language = {eng},
   issn = {1474-905X},
   journal = {PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES},
   title = {Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window},
   url = {https://pubs.rsc.org/en/Content/ArticleLanding/2018/PP/C8PP00096D#!divAbstract},
   volume = {17},
   year = {2018}
}

TY  - JOUR
ID  - 1473623
AU  - Slanina, Tomáš - Šebej, Peter
PY  - 2018
TI  - Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window
JF  - PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
VL  - 17
IS  - 6
SP  - 692-710
EP  - 692-710
PB  - ROYAL SOC CHEMISTRY
SN  - 1474905X
KW  - PHOTOREMOVABLE PROTECTING GROUPS
KW  - METAL-CARBONYL-COMPLEXES
KW  - PROTEIN-KINASE PATHWAY
KW  - LIVING CELLS
KW  - NITRIC-OXIDE
KW  - AQUEOUS-SOLUTION
KW  - NIR LIGHT
KW  - IN-VIVO
KW  - STRUCTURAL-CHARACTERIZATION
KW  - XANTHENE-9-CARBOXYLIC ACID
UR  - https://pubs.rsc.org/en/Content/ArticleLanding/2018/PP/C8PP00096D#!divAbstract
L2  - https://pubs.rsc.org/en/Content/ArticleLanding/2018/PP/C8PP00096D#!divAbstract
N2  - To date, most known molecules that release carbon monoxide by the action of light are based on carbonyl complexes of metals. However, they suffer from several disadvantages, so the focus of this perspective is on photoactivatable metal-free CO precursors. The development and design of these systems from the starting point of deep-UV-absorbing hydrophobic molecules and leading to hydrophilic biocompatible visible-light-absorbing CO-releasing molecules (photoCORMs) is described with mechanistic details for several structural motifs. The possibilities of this development are not exhausted and here we discuss the design of new biologically interesting candidates.
ER  -

SLANINA, Tomáš a Peter ŠEBEJ. Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window. \textit{PHOTOCHEMICAL \&{}amp; PHOTOBIOLOGICAL SCIENCES}. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2018, roč.~17, č.~6, s.~692-710. ISSN~1474-905X. Dostupné z: https://dx.doi.org/10.1039/c8pp00096d.

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