J 2018

Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study

PILER, Pavel, Jan ŠVANCARA, Lubomír KUKLA a Hynek PIKHART

Základní údaje

Originální název

Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study

Autoři

PILER, Pavel (203 Česká republika, domácí), Jan ŠVANCARA (203 Česká republika, domácí), Lubomír KUKLA (203 Česká republika, domácí) a Hynek PIKHART (203 Česká republika, garant, domácí)

Vydání

Journal of Epidemiology and Community Health, LONDON, BMJ PUBLISHING GROUP, 2018, 0143-005X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 3.872

Kód RIV

RIV/00216224:14310/18:00104779

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000429428000014

Klíčová slova anglicky

asthma; drug safety; cohort studies; epidemiology

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 9. 1. 2019 19:12, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Background Prenatal and postnatal paracetamol exposure has been previously associated with asthma development in childhood in Western populations. We explore the association between prenatal and postnatal paracetamol exposure and asthma development in a Central European sample of Czech children, suggesting possible additive effect of the both exposures. Furthermore, since aspirin had been used more widely during study data collection in Central Europe, we also compared asthma development for those exposed to paracetamol and aspirin. Methods We used data from 3329 children born in the 1990s as members of the prospective Czech European Longitudinal Study of Pregnancy and Childhood. Data about prenatal and postnatal paracetamol and aspirin exposure, and potential covariates were obtained from questionnaires completed by mothers. Data about incident asthma were obtained from paediatrician health records. Results 60.9% of children received paracetamol only postnatally, 1.5% only prenatally and 4.9% of children were exposed both during pregnancy and infancy. Prevalence of asthma in following population was 5% at 11 years. Being exposed to paracetamol both in prenatal and postnatal period was associated with asthma development (unadjusted OR 1.98, 95%CI 1.02 to 3.87). Being exposed only in the postnatal period was also significantly associated with increased risk of asthma. No association between prenatal exposure only and outcome was found. A higher but non-significant risk of asthma was observed for those whose mothers used paracetamol during pregnancy compared with those who used aspirin. Conclusions The main findings of this prospective birth cohort study add to previous observations linking prenatal and early postnatal paracetamol exposure to asthma development. However, the magnitude of effect is relatively modest, and therefore, we recommend paracetamol to remain the analgesic and antipyretic of choice throughout pregnancy and early childhood.

Návaznosti

CZ.02.1.01/0.0/0.0/16_013/0001761, interní kód MU
Název: RECETOX RI - OP VVV (Akronym: RECETOX RI)
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI - OP VVV, PO 1 Posilování kapacit pro kvalitní výzkum
EF15_003/0000469, projekt VaV
Název: Cetocoen Plus
LM2015051, projekt VaV
Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX