Testing of N-alkoxyphenylhydronaphthalenecarboxamide activity
against intestinal sulfate reducing bacteria

D 2018

Testing of N-alkoxyphenylhydronaphthalenecarboxamide activity against intestinal sulfate reducing bacteria

KUSHKEVYCH, Ivan, Oľga LEŠČANOVÁ, Tomáš GONĚC, Peter KOLLÁR, Josef JAMPÍLEK et. al.

Základní údaje

Originální název

Testing of N-alkoxyphenylhydronaphthalenecarboxamide activity against intestinal sulfate reducing bacteria

Autoři

KUSHKEVYCH, Ivan (804 Ukrajina, domácí), Oľga LEŠČANOVÁ (703 Slovensko, domácí), Tomáš GONĚC (203 Česká republika), Peter KOLLÁR (203 Česká republika) a Josef JAMPÍLEK (703 Slovensko)

Vydání

VFU Brno. BRNO, SBORNÍK PŘÍSPĚVKŮ z výsledků řešení projektů IGA VFU Brno 2018 financovaných z prostředků účelové podpory na specifický vysokoškolský výzkum MŠMT na rok 2018, od s. 176-179, 4 s. 2018

Nakladatel

VFU Brno

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10606 Microbiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

elektronická verze "online"

Kód RIV

RIV/00216224:14310/18:00104856

Organizační jednotka

Přírodovědecká fakulta

ISBN

978-80-7305-811-1

Klíčová slova anglicky

Sulfate-reducing bacteria; IBD; 8-hydroxyquinoline-2-carboxanilides

Změněno: 10. 12. 2018 11:25, doc. Ivan Kushkevych, Ph.D.

Anotace

V originále

The increased number of sulfate-reducing bacteria (SRB) and the intense process of dissimilatory sulfate reduction in the gut are thought to be significant risk factors of inflammatory bowel diseases in both humans and animals. These bacteria are often found in persons with rheumatic diseases, ankylosing spondylitis, etc. [1]. There is also an assumption that SRB can be responsible for some forms of cancer of the rectum through the formation of hydrogen sulfide that affects the metabolism of intestinal cells and give rise to various inflammatory bowel diseases [2,3]. Hydroxynaphthalene-2-carboxanilides can be considered as cyclic analogues of salicylanilides that have expressed promising results as potential antimicrobial agents. Their antimicrobial effects are connected with the ability of vicinal hydroxyarylamides to inhibit various enzymatic systems in bacteria. In addition, the presence of an amide group with a hydrophobic residue in its close vicinity is able, due to its electron properties, to interact and bind with a number of enzymes/receptors and affect the biological response by means of these target sites. The properties of the amide moiety can be easily modified by various substitutions [4,5]. In our previous research, antimicrobial effect of salicylamide derivatives against intestinal sulfatereducing bacteria as well as influence of selected 8-hydroxyquinoline-2-carboxanilides on viability and sulfate metabolism of Desulfovibrio piger were studied and described [6-7]. The present work is focused on investigation of the biological activity of N-alkoxyfenyl-3-hydroxynaftalen-2-carboxamides against intestinal sulfate-reducing bacteria isolated from mice.

Citovat

KUSHKEVYCH, Ivan, Oľga LEŠČANOVÁ, Tomáš GONĚC, Peter KOLLÁR a Josef JAMPÍLEK. Testing of N-alkoxyphenylhydronaphthalenecarboxamide activity against intestinal sulfate reducing bacteria. Online. In doc. MVDr. Pavel Suchý, Ph.D. SBORNÍK PŘÍSPĚVKŮ z výsledků řešení projektů IGA VFU Brno 2018 financovaných z prostředků účelové podpory na specifický vysokoškolský výzkum MŠMT na rok 2018. VFU Brno. BRNO: VFU Brno, 2018, s. 176-179. ISBN 978-80-7305-811-1.

@inproceedings{1476872,
   author = {Kushkevych, Ivan and Leščanová, Oľga and Goněc, Tomáš and Kollár, Peter and Jampílek, Josef},
   address = {BRNO},
   booktitle = {SBORNÍK PŘÍSPĚVKŮ z výsledků řešení projektů IGA VFU Brno 2018 financovaných z prostředků účelové podpory na specifický vysokoškolský výzkum MŠMT na rok 2018},
   edition = {VFU Brno},
   editor = {doc. MVDr. Pavel Suchý, Ph.D.},
   keywords = {Sulfate-reducing bacteria; IBD; 8-hydroxyquinoline-2-carboxanilides},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {BRNO},
   isbn = {978-80-7305-811-1},
   pages = {176-179},
   publisher = {VFU Brno},
   title = {Testing of N-alkoxyphenylhydronaphthalenecarboxamide activity against intestinal sulfate reducing bacteria},
   year = {2018}
}

TY  - JOUR
ID  - 1476872
AU  - Kushkevych, Ivan - Leščanová, Oľga - Goněc, Tomáš - Kollár, Peter - Jampílek, Josef
PY  - 2018
TI  - Testing of N-alkoxyphenylhydronaphthalenecarboxamide activity against intestinal sulfate reducing bacteria
PB  - VFU Brno
CY  - BRNO
SN  - 9788073058111
KW  - Sulfate-reducing bacteria
KW  - IBD
KW  - 8-hydroxyquinoline-2-carboxanilides
N2  - The increased number of sulfate-reducing bacteria (SRB) and the intense process of dissimilatory sulfate reduction in the gut are thought to be significant risk factors of inflammatory bowel diseases in both humans and animals. These bacteria are often found in persons with rheumatic diseases, ankylosing spondylitis, etc. [1]. There is also an assumption that SRB can be responsible for some forms of cancer of the rectum through the formation of hydrogen sulfide that affects the metabolism of intestinal cells and give rise to various inflammatory bowel diseases [2,3]. Hydroxynaphthalene-2-carboxanilides can be considered as cyclic analogues of salicylanilides that have expressed promising results as potential antimicrobial agents. Their antimicrobial effects are connected with the ability of vicinal hydroxyarylamides to inhibit various enzymatic systems in bacteria. In addition, the presence of an amide group with a hydrophobic residue in its close vicinity is able, due to its electron properties, to interact and bind with a number of enzymes/receptors and affect the biological response by means of these target sites. The properties of the amide moiety can be easily modified by various substitutions [4,5]. In our previous research, antimicrobial effect of salicylamide derivatives against intestinal sulfatereducing bacteria as well as influence of selected 8-hydroxyquinoline-2-carboxanilides on viability and sulfate metabolism of Desulfovibrio piger were studied and described [6-7]. The present work is focused on investigation of the biological activity of N-alkoxyfenyl-3-hydroxynaftalen-2-carboxamides against intestinal sulfate-reducing bacteria isolated from mice.
ER  -

KUSHKEVYCH, Ivan, Oľga LEŠČANOVÁ, Tomáš GONĚC, Peter KOLLÁR a Josef JAMPÍLEK. Testing of N-alkoxyphenylhydronaphthalenecarboxamide activity against intestinal sulfate reducing bacteria. Online. In doc. MVDr. Pavel Suchý, Ph.D. \textit{SBORNÍK PŘÍSPĚVKŮ z výsledků řešení projektů IGA VFU Brno 2018 financovaných z prostředků účelové podpory na specifický vysokoškolský výzkum MŠMT na rok 2018}. VFU Brno. BRNO: VFU Brno, 2018, s.~176-179. ISBN~978-80-7305-811-1.

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