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@article{1476881,
author = {Večeřa, Marek and Šána, Jiří and Lipina, R. and Smrčka, Martin and Slabý, Ondřej},
article_location = {Basel, Switzerland},
article_number = {9},
doi = {http://dx.doi.org/10.3390/ijms19092754},
keywords = {glioma; glioblastoma; long non-coding RNA; biomarker; diagnosis; prognosis; molecular pathology},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Long Non-Coding RNAs in Gliomas: From Molecular Pathology to Diagnostic Biomarkers and Therapeutic Targets},
url = {https://www.mdpi.com/1422-0067/19/9/2754},
volume = {19},
year = {2018}
}
TY - JOUR
ID - 1476881
AU - Večeřa, Marek - Šána, Jiří - Lipina, R. - Smrčka, Martin - Slabý, Ondřej
PY - 2018
TI - Long Non-Coding RNAs in Gliomas: From Molecular Pathology to Diagnostic Biomarkers and Therapeutic Targets
JF - International Journal of Molecular Sciences
VL - 19
IS - 9
SP - 2754
EP - 2754
PB - MDPI AG
SN - 14220067
KW - glioma
KW - glioblastoma
KW - long non-coding RNA
KW - biomarker
KW - diagnosis
KW - prognosis
KW - molecular pathology
UR - https://www.mdpi.com/1422-0067/19/9/2754
N2 - Gliomas are the most common malignancies of the central nervous system. Because of tumor localization and the biological behavior of tumor cells, gliomas are characterized by very poor prognosis. Despite significant efforts that have gone into glioma research in recent years, the therapeutic efficacy of available treatment options is still limited, and only a few clinically usable diagnostic biomarkers are available. More and more studies suggest non-coding RNAs to be promising diagnostic biomarkers and therapeutic targets in many cancers, including gliomas. One of the largest groups of these molecules is long non-coding RNAs (lncRNAs). LncRNAs show promising potential because of their unique tissue expression patterns and regulatory functions in cancer cells. Understanding the role of lncRNAs in gliomas may lead to discovery of the novel molecular mechanisms behind glioma biological features. It may also enable development of new solutions to overcome the greatest obstacles in therapy of glioma patients. In this review, we summarize the current knowledge about lncRNAs and their involvement in the molecular pathology of gliomas. A conclusion follows that these RNAs show great potential to serve as powerful diagnostic, prognostic, and predictive biomarkers as well as therapeutic targets.
ER -
VEČEŘA, Marek, Jiří ŠÁNA, R. LIPINA, Martin SMRČKA a Ondřej SLABÝ. Long Non-Coding RNAs in Gliomas: From Molecular Pathology to Diagnostic Biomarkers and Therapeutic Targets. \textit{International Journal of Molecular Sciences}. Basel, Switzerland: MDPI AG, 2018, roč.~19, č.~9, s.~2754-2768. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19092754.
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