Long Non-Coding RNAs in Gliomas: From Molecular Pathology to
Diagnostic Biomarkers and Therapeutic Targets

J 2018

Long Non-Coding RNAs in Gliomas: From Molecular Pathology to Diagnostic Biomarkers and Therapeutic Targets

VEČEŘA, Marek, Jiří ŠÁNA, R. LIPINA, Martin SMRČKA, Ondřej SLABÝ et. al.

Základní údaje

Originální název

Long Non-Coding RNAs in Gliomas: From Molecular Pathology to Diagnostic Biomarkers and Therapeutic Targets

Autoři

VEČEŘA, Marek (703 Slovensko, domácí), Jiří ŠÁNA (203 Česká republika, domácí), R. LIPINA (203 Česká republika), Martin SMRČKA (203 Česká republika, domácí) a Ondřej SLABÝ (203 Česká republika, garant, domácí)

Vydání

International Journal of Molecular Sciences, Basel, Switzerland, MDPI AG, 2018, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.183

Kód RIV

RIV/00216224:14740/18:00104857

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.3390/ijms19092754

UT WoS

000449988100290

Klíčová slova anglicky

glioma; glioblastoma; long non-coding RNA; biomarker; diagnosis; prognosis; molecular pathology

Štítky

14110224, 14110811, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 3. 2019 16:17, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Gliomas are the most common malignancies of the central nervous system. Because of tumor localization and the biological behavior of tumor cells, gliomas are characterized by very poor prognosis. Despite significant efforts that have gone into glioma research in recent years, the therapeutic efficacy of available treatment options is still limited, and only a few clinically usable diagnostic biomarkers are available. More and more studies suggest non-coding RNAs to be promising diagnostic biomarkers and therapeutic targets in many cancers, including gliomas. One of the largest groups of these molecules is long non-coding RNAs (lncRNAs). LncRNAs show promising potential because of their unique tissue expression patterns and regulatory functions in cancer cells. Understanding the role of lncRNAs in gliomas may lead to discovery of the novel molecular mechanisms behind glioma biological features. It may also enable development of new solutions to overcome the greatest obstacles in therapy of glioma patients. In this review, we summarize the current knowledge about lncRNAs and their involvement in the molecular pathology of gliomas. A conclusion follows that these RNAs show great potential to serve as powerful diagnostic, prognostic, and predictive biomarkers as well as therapeutic targets.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NV15-33158A, projekt VaV

Název: Nová úroveň molekulární taxonomie glioblastomu založená na expresních profilech dlouhých nekódujících RNA: implikace pro diagnostiku a terapii

NV15-34553A, projekt VaV

Název: Využití mikroRNA v mozkomíšním moku pro diagnostiku mozkových nádorů

Citovat

VEČEŘA, Marek, Jiří ŠÁNA, R. LIPINA, Martin SMRČKA a Ondřej SLABÝ. Long Non-Coding RNAs in Gliomas: From Molecular Pathology to Diagnostic Biomarkers and Therapeutic Targets. International Journal of Molecular Sciences. Basel, Switzerland: MDPI AG, 2018, roč. 19, č. 9, s. 2754-2768. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19092754.

@article{1476881,
   author = {Večeřa, Marek and Šána, Jiří and Lipina, R. and Smrčka, Martin and Slabý, Ondřej},
   article_location = {Basel, Switzerland},
   article_number = {9},
   doi = {http://dx.doi.org/10.3390/ijms19092754},
   keywords = {glioma; glioblastoma; long non-coding RNA; biomarker; diagnosis; prognosis; molecular pathology},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Long Non-Coding RNAs in Gliomas: From Molecular Pathology to Diagnostic Biomarkers and Therapeutic Targets},
   url = {https://www.mdpi.com/1422-0067/19/9/2754},
   volume = {19},
   year = {2018}
}

TY  - JOUR
ID  - 1476881
AU  - Večeřa, Marek - Šána, Jiří - Lipina, R. - Smrčka, Martin - Slabý, Ondřej
PY  - 2018
TI  - Long Non-Coding RNAs in Gliomas: From Molecular Pathology to Diagnostic Biomarkers and Therapeutic Targets
JF  - International Journal of Molecular Sciences
VL  - 19
IS  - 9
SP  - 2754
EP  - 2754
PB  - MDPI AG
SN  - 14220067
KW  - glioma
KW  - glioblastoma
KW  - long non-coding RNA
KW  - biomarker
KW  - diagnosis
KW  - prognosis
KW  - molecular pathology
UR  - https://www.mdpi.com/1422-0067/19/9/2754
N2  - Gliomas are the most common malignancies of the central nervous system. Because of tumor localization and the biological behavior of tumor cells, gliomas are characterized by very poor prognosis. Despite significant efforts that have gone into glioma research in recent years, the therapeutic efficacy of available treatment options is still limited, and only a few clinically usable diagnostic biomarkers are available. More and more studies suggest non-coding RNAs to be promising diagnostic biomarkers and therapeutic targets in many cancers, including gliomas. One of the largest groups of these molecules is long non-coding RNAs (lncRNAs). LncRNAs show promising potential because of their unique tissue expression patterns and regulatory functions in cancer cells. Understanding the role of lncRNAs in gliomas may lead to discovery of the novel molecular mechanisms behind glioma biological features. It may also enable development of new solutions to overcome the greatest obstacles in therapy of glioma patients. In this review, we summarize the current knowledge about lncRNAs and their involvement in the molecular pathology of gliomas. A conclusion follows that these RNAs show great potential to serve as powerful diagnostic, prognostic, and predictive biomarkers as well as therapeutic targets.
ER  -

VEČEŘA, Marek, Jiří ŠÁNA, R. LIPINA, Martin SMRČKA a Ondřej SLABÝ. Long Non-Coding RNAs in Gliomas: From Molecular Pathology to Diagnostic Biomarkers and Therapeutic Targets. \textit{International Journal of Molecular Sciences}. Basel, Switzerland: MDPI AG, 2018, roč.~19, č.~9, s.~2754-2768. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19092754.

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