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@proceedings{1478396,
author = {Celá, Andrea and Mádr, Aleš and Schejbal, Jan and Glatz, Zdeněk},
booktitle = {The 11th International Symposium on Drug Analysis and the 29th International Symposium on Pharmaceutical and Biomedical Analysis (DA-PBA)},
keywords = {Alzheimer's disease, β-secretase, capillary electrophoresis, fluorescent detection, derivatization},
language = {eng},
title = {CE-LIF method for β-secretase enzyme assays as a potential target treatment of Alzheimer's disease},
year = {2018}
}
TY - CONF
ID - 1478396
AU - Celá, Andrea - Mádr, Aleš - Schejbal, Jan - Glatz, Zdeněk
PY - 2018
TI - CE-LIF method for β-secretase enzyme assays as a potential target treatment of Alzheimer's disease
KW - Alzheimer's disease, β-secretase, capillary electrophoresis, fluorescent detection, derivatization
N2 - Alzheimer's disease is cause of 60-70 % cases of dementia worldwide. It is chronic neurodegenerative disease characterized by loss of neurons and synapses in the cerebral cortex and certain subcortical regions and cerebral accumulation of amyloid plaques and neurofibrillary tangles. Based on amyloid hypothesis, inhibition of β-secretase enzyme is one of the target treatments of Alzheimer's disease. For β-secretase enzyme assays a novel method by means of capillary electrophoresis with fluorescence detection was developed.
ER -
CELÁ, Andrea, Aleš MÁDR, Jan SCHEJBAL a Zdeněk GLATZ. CE-LIF method for β-secretase enzyme assays as a potential target treatment of Alzheimer's disease. In \textit{The 11th International Symposium on Drug Analysis and the 29th International Symposium on Pharmaceutical and Biomedical Analysis (DA-PBA)}. 2018.
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