2018
Hematological Findings in Non-Treated and gamma-Irradiated Mice Deficient for MIC-1/GDF15
HOFER, M., Z. HOFEROVA, Ján REMŠÍK, M. NOVAKOVA, J. PROCHAZKOVA et. al.Základní údaje
Originální název
Hematological Findings in Non-Treated and gamma-Irradiated Mice Deficient for MIC-1/GDF15
Autoři
HOFER, M. (203 Česká republika, garant), Z. HOFEROVA (203 Česká republika), Ján REMŠÍK (703 Slovensko, domácí), M. NOVAKOVA (203 Česká republika), J. PROCHAZKOVA (203 Česká republika), R. FEDR (203 Česká republika), J. KOHOUTEK (203 Česká republika), Ladislav DUŠEK (203 Česká republika, domácí), Aleš HAMPL (203 Česká republika, domácí) a K. SOUČEK (203 Česká republika)
Vydání
Physiological research, Praha, Fyziologický ústav AV ČR, 2018, 0862-8408
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30105 Physiology
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.701
Kód RIV
RIV/00216224:14110/18:00101446
Organizační jednotka
Lékařská fakulta
UT WoS
000442016100011
Klíčová slova anglicky
GDF15 knockout mice; Hematopoiesis; Ionizing radiation; Stress-induced cytokine
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 13. 12. 2019 16:06, Mgr. Michal Petr
Anotace
V originále
Several members of the TGF-beta family are known to effectively regulate the fate of hematopoietic progenitor cells in a complex and context-dependent manner. Growth differentiation factor-15 (GDF15) is a divergent member of the TGF-beta family. This stress-induced cytokine has been proposed to possess immunomodulatory functions and its high expression is often associated with progression of a variety of pathological conditions. GDF15 is also induced by chemotherapy and irradiation. Very few fundamental studies have been published regarding the effect of GDF15 in hematopoiesis. In this study, we analyzed the hematological status of untreated and gamma-irradiated mice deficient for GDF15 as a result of genetic knock-out (KO), in order to clarify the regulatory role of GDF15 in hematopoiesis. Significant differences between GDF15 KO mice and their pertinent WT controls were found in the parameters of blood monocyte numbers, blood platelet size, and distribution width, as well as in the values of bone marrow granulocyte/macrophage progenitor cells. Different tendencies of some hematological parameters in the GDF15 KO mice in normal conditions and those under exposure of the mice to ionizing radiation were registered. These findings are discussed in the context of the GDF15 gene function and its lack under conditions of radiation-induced damage.
Návaznosti
| EE2.3.20.0185, projekt VaV |
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| GA15-11707S, projekt VaV |
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| GA16-12454S, projekt VaV |
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| NV15-33999A, projekt VaV |
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