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@article{1479856, author = {Piskáček, Martin and Havelka, Marek and Jendruchová, Kristína and Knight, Andrea}, article_location = {Oxford}, article_number = {MAR 2019}, doi = {http://dx.doi.org/10.1016/j.jsbmb.2018.11.008}, keywords = {9aaTAD; CBP; HNF4; KIX; MED15; PPAR; RARa; VDL}, language = {eng}, issn = {0960-0760}, journal = {Journal of steroid biochemistry and molecular biology}, title = {Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways}, url = {http://dx.doi.org/10.1016/j.jsbmb.2018.11.008}, volume = {187}, year = {2019} }
TY - JOUR ID - 1479856 AU - Piskáček, Martin - Havelka, Marek - Jendruchová, Kristína - Knight, Andrea PY - 2019 TI - Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways JF - Journal of steroid biochemistry and molecular biology VL - 187 IS - MAR 2019 SP - 118-123 EP - 118-123 PB - Pergamon-Elsevier Science SN - 09600760 KW - 9aaTAD KW - CBP KW - HNF4 KW - KIX KW - MED15 KW - PPAR KW - RARa KW - VDL UR - http://dx.doi.org/10.1016/j.jsbmb.2018.11.008 L2 - http://dx.doi.org/10.1016/j.jsbmb.2018.11.008 N2 - In higher metazoans, the nuclear hormone receptors activate transcription trough their specific adaptors, nuclear hormone receptor adaptors NCoA, which are absent in lower metazoans. The Nine amino acid TransActivation Domain, 9aaTAD, was reported for a large number of the transcription activators that recruit general mediators of transcription. In this study, we demonstrated that the 9aaTAD from NHR-49 receptor of nematode C.elegans activates transcription as a small peptide. We showed that the ancient 9aaTAD domains are conserved in the nuclear hormone receptors including human HNF4, RARa, VDR and PPARg. Also their small 9aaTAD peptides effectively activated transcription in absence of the NCoA adaptors. We also showed that adjacent H11 domains in ancient and modern hormone receptors have an inhibitory effect on their 9aaTAD function. ER -
PISKÁČEK, Martin, Marek HAVELKA, Kristína JENDRUCHOVÁ a Andrea KNIGHT. Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways. \textit{Journal of steroid biochemistry and molecular biology}. Oxford: Pergamon-Elsevier Science, 2019, roč.~187, MAR 2019, s.~118-123. ISSN~0960-0760. Dostupné z: https://dx.doi.org/10.1016/j.jsbmb.2018.11.008.
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