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@article{1479859,
author = {Pávková Goldbergová, Monika and Lipková, Jolana and Fedorko, Jan and Němec, Petr and Gatterová, Jindřiška and Válková, Lucie and Veverková, Jana and Vašků, Anna},
article_location = {Bratislava},
article_number = {6},
doi = {http://dx.doi.org/10.4149/gpb_2018024},
keywords = {Rheumatoid arthritis; Protein; microRNA; Expression; MMP},
language = {eng},
issn = {0231-5882},
journal = {General physiology and biophysics},
title = {Relationship of epigenetic variability of miR-124 to extracellular matrix remodelling and age-related MMP-3 expression in rheumatoid arthritis},
volume = {37},
year = {2018}
}
TY - JOUR
ID - 1479859
AU - Pávková Goldbergová, Monika - Lipková, Jolana - Fedorko, Jan - Němec, Petr - Gatterová, Jindřiška - Válková, Lucie - Veverková, Jana - Vašků, Anna
PY - 2018
TI - Relationship of epigenetic variability of miR-124 to extracellular matrix remodelling and age-related MMP-3 expression in rheumatoid arthritis
JF - General physiology and biophysics
VL - 37
IS - 6
SP - 703-710
EP - 703-710
PB - Ústav molekulárnej fyziológie a genetiky SAV
SN - 02315882
KW - Rheumatoid arthritis
KW - Protein
KW - microRNA
KW - Expression
KW - MMP
N2 - The aim of study was to examine relation among miR-124 and serum levels of selected cytokines and chemokines, MMP-3, production of auto-antibodies, and factors describing clinical activity (DAS28) and radiographic progression in rheumatoid arthritis (RA). A total of 80 RA patients according to the ACR classification criteria, and 32 control subjects were recruited into study. The measurements of miR-124 and U-6 expression, CRP anti-CCP, rheumatoid factors (RFs), radiographs of both hands with calculation of total sharp score (TSS), DAS28 and cytokines, chemokines and MMP levels in serum were obtained from all RA patients. miR-124 was down-regulated in RA patients compared to controls (7-fold decrease). The miR-124 expression correlated to MMP-3 levels (p < 0.001), which were in multivariate analysis associated to age of RA onset. Higher levels were detected in younger subjects. No relation of miR-124 expression to measures of RA activity (DAS28 score; TSS), auto-antibodies (anti-CCP, RR, RF IgG, RF IgA, RF IgM), acute inflammatory markers (CRP, IL-6), and other cytokine and chemokines (IL-13, IL-15, IL-8, TNF-alpha, MCP-1, RANTES) was observed. In conclusion, we present a down-regulation of miR-124 in RA patients and its correlation to MMP-3 levels, which associated to age of RA onset.
ER -
PÁVKOVÁ GOLDBERGOVÁ, Monika, Jolana LIPKOVÁ, Jan FEDORKO, Petr NĚMEC, Jindřiška GATTEROVÁ, Lucie VÁLKOVÁ, Jana VEVERKOVÁ and Anna VAŠKŮ. Relationship of epigenetic variability of miR-124 to extracellular matrix remodelling and age-related MMP-3 expression in rheumatoid arthritis. \textit{General physiology and biophysics}. Bratislava: Ústav molekulárnej fyziológie a genetiky SAV, 2018, vol.~37, No~6, p.~703-710. ISSN~0231-5882. Available from: https://dx.doi.org/10.4149/gpb\_{}2018024.
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