The role of the NOD2/CARD15 gene in surgical treatment
prediction in patients with Crohn’s disease

J 2019

The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn’s disease

KUNOVSKÝ, Lumír, Zdeněk KALA, Filip MAREK, Jiří DOLINA, Karolina POREDSKÁ et. al.

Základní údaje

Originální název

The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn’s disease

Autoři

KUNOVSKÝ, Lumír (203 Česká republika, domácí), Zdeněk KALA (203 Česká republika, domácí), Filip MAREK (203 Česká republika, garant, domácí), Jiří DOLINA (203 Česká republika, domácí), Karolina POREDSKÁ (203 Česká republika, domácí), Lenka KUČEROVÁ (203 Česká republika, domácí), Klára BENEŠOVÁ (203 Česká republika, domácí) a Ladislav MITÁŠ (203 Česká republika, domácí)

Vydání

International Journal of Colorectal Disease, New York, Springer, 2019, 0179-1958

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30212 Surgery

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.108

Kód RIV

RIV/00216224:14110/19:00108963

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s00384-018-3122-7

UT WoS

000455824400018

Klíčová slova anglicky

Crohn’s disease; Czech cohort; Disease course; Genetics; Inflammatory bowel disease; Intestinal resection; NOD2/CARD15; Surgery

Štítky

14110213, 14110223, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 5. 2020 08:16, Mgr. Tereza Miškechová

Anotace

V originále

Purpose: Crohn’s disease (CD) belongs to chronic disorders with unpredictable disease course. The aim of this study was to identify how genetic testing (NOD2/CARD15) can be used in patients with CD to predict the need for surgical treatment (to define an aggressive type of disease where the patient can profit from early surgery). Methods: The patients who were tested genetically had undergone a surgery due to CD at the Department of Surgery University Hospital Brno Bohunice between 2010 and 2016. The control group consisted of patients with CD who had been diagnosed with CD at least 5 years prior to the testing and had not required any surgical intervention. The second control group was healthy subjects. Results: In total, there were 117 operated patients for CD, 77 patients with CD that had not undergone surgery for CD and 30 healthy subjects. For patients with at least one genetic mutation, the risk of the necessity of surgical treatment of CD is 1.96 times higher than for patients with no mutation. Patients with two or more mutations were generally operated on at a younger age, in a shorter time after being diagnosed and each patient had a partial resection of the ileum. Conclusion: The group of operated patients with CD had a significantly higher distribution of at least one genetic mutation as opposed to the non-operated group. In patients with two or more mutations, the disease course was more aggressive. This group of patients might profit from the conservative top-down or early surgical therapy.

Citovat

KUNOVSKÝ, Lumír, Zdeněk KALA, Filip MAREK, Jiří DOLINA, Karolina POREDSKÁ, Lenka KUČEROVÁ, Klára BENEŠOVÁ a Ladislav MITÁŠ. The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn’s disease. International Journal of Colorectal Disease. New York: Springer, 2019, roč. 34, č. 2, s. 347-351. ISSN 0179-1958. Dostupné z: https://dx.doi.org/10.1007/s00384-018-3122-7.

@article{1479867,
   author = {Kunovský, Lumír and Kala, Zdeněk and Marek, Filip and Dolina, Jiří and Poredská, Karolina and Kučerová, Lenka and Benešová, Klára and Mitáš, Ladislav},
   article_location = {New York},
   article_number = {2},
   doi = {http://dx.doi.org/10.1007/s00384-018-3122-7},
   keywords = {Crohn’s disease; Czech cohort; Disease course; Genetics; Inflammatory bowel disease; Intestinal resection; NOD2/CARD15; Surgery},
   language = {eng},
   issn = {0179-1958},
   journal = {International Journal of Colorectal Disease},
   title = {The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn’s disease},
   url = {http://dx.doi.org/10.1007/s00384-018-3122-7},
   volume = {34},
   year = {2019}
}

TY  - JOUR
ID  - 1479867
AU  - Kunovský, Lumír - Kala, Zdeněk - Marek, Filip - Dolina, Jiří - Poredská, Karolina - Kučerová, Lenka - Benešová, Klára - Mitáš, Ladislav
PY  - 2019
TI  - The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn’s disease
JF  - International Journal of Colorectal Disease
VL  - 34
IS  - 2
SP  - 347-351
EP  - 347-351
PB  - Springer
SN  - 01791958
KW  - Crohn’s disease
KW  - Czech cohort
KW  - Disease course
KW  - Genetics
KW  - Inflammatory bowel disease
KW  - Intestinal resection
KW  - NOD2/CARD15
KW  - Surgery
UR  - http://dx.doi.org/10.1007/s00384-018-3122-7
L2  - http://dx.doi.org/10.1007/s00384-018-3122-7
N2  - Purpose: Crohn’s disease (CD) belongs to chronic disorders with unpredictable disease course. The aim of this study was to identify how genetic testing (NOD2/CARD15) can be used in patients with CD to predict the need for surgical treatment (to define an aggressive type of disease where the patient can profit from early surgery). Methods: The patients who were tested genetically had undergone a surgery due to CD at the Department of Surgery University Hospital Brno Bohunice between 2010 and 2016. The control group consisted of patients with CD who had been diagnosed with CD at least 5 years prior to the testing and had not required any surgical intervention. The second control group was healthy subjects. Results: In total, there were 117 operated patients for CD, 77 patients with CD that had not undergone surgery for CD and 30 healthy subjects. For patients with at least one genetic mutation, the risk of the necessity of surgical treatment of CD is 1.96 times higher than for patients with no mutation. Patients with two or more mutations were generally operated on at a younger age, in a shorter time after being diagnosed and each patient had a partial resection of the ileum. Conclusion: The group of operated patients with CD had a significantly higher distribution of at least one genetic mutation as opposed to the non-operated group. In patients with two or more mutations, the disease course was more aggressive. This group of patients might profit from the conservative top-down or early surgical therapy.
ER  -

KUNOVSKÝ, Lumír, Zdeněk KALA, Filip MAREK, Jiří DOLINA, Karolina POREDSKÁ, Lenka KUČEROVÁ, Klára BENEŠOVÁ a Ladislav MITÁŠ. The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn’s disease. \textit{International Journal of Colorectal Disease}. New York: Springer, 2019, roč.~34, č.~2, s.~347-351. ISSN~0179-1958. Dostupné z: https://dx.doi.org/10.1007/s00384-018-3122-7.

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