2018
Wound healing effects after application of polyunsaturated fatty acids in rat
HOKYNKOVÁ, Alica; Zdeněk WILHELM; Marie NOVÁKOVÁ; Petr BABULA; Tibor STRAČINA et al.Základní údaje
Originální název
Wound healing effects after application of polyunsaturated fatty acids in rat
Název česky
Změny v kvalitě hojení ran po podání nenasycených mastných kyselin u potkana
Název anglicky
Wound healing effects after application of polyunsaturated fatty acids in rat
Autoři
HOKYNKOVÁ, Alica; Zdeněk WILHELM; Marie NOVÁKOVÁ; Petr BABULA; Tibor STRAČINA ORCID; Hana PAULOVÁ; Miroslava HLAVÁČOVÁ a Miroslava SEDLÁČKOVÁ
Vydání
Česká a slovenská neurologie a neurochirurgie, Praha, Česká lékařská společnost J.E. Purkyně, 2018, 1210-7859
Další údaje
Jazyk
slovenština
Typ výsledku
Článek v odborném periodiku
Obor
30105 Physiology
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 0.355
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14110/18:00104972
Organizační jednotka
Lékařská fakulta
UT WoS
EID Scopus
Klíčová slova česky
nenasycené mastné kyseliny; hojení ran; antioxidační kapacita; 4-HNE; 4-hydroxy-2-nonenal
Klíčová slova anglicky
polyunsaturated fatty acids; wound healing; anti-oxidative capacity; 4-1-INE; 4-hydroxy-2-nonenal
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 23. 4. 2024 10:08, Mgr. Michal Petr
V originále
Introduction: Although mechanisms of polyunsaturated fatty acids influence on skin wound heal- ing have not been fully elucidated yet, it is undisputable that nutritional state affects it profoundly. Aim: The study was focused on speed and quality of wound healing influenced by short-lasting oral administration of omega-3 and omega-6 polyunsaturated fatty acids. Materials and methods: Young Wistar rats received by orogastric tube either 20% fat emulsion (experimental groups E and F differed by ratio between omega-3 : omega-6 : omega-9 polyunsaturated fatty acids) or water (control group C). After 7 days, skin wound on back was performed and emulsion or water application continued for another week. Blood and tissue samples were obtained during experiment termination. Plasmatic levels of fatty acids, 4-hydroxy-2-nonenal and oxidative stress both in plasma and in wound tissue were examined. Speed and quality of wound healing were assessed by digital planimetry and histological examination. Results were statistically evaluated by non-parametric tests. Results: Significant changes of fatty acids plasmatic levels were observed in animals in experimental groups as well as better ability of their plasma and tissues to cope with oxidative stress. Conclusion: Short-lasting administration of certain ratio of polyunsaturated fatty acids positively affects skin wound healing.
Anglicky
Although mechanisms of fatty acids influence on skin wound healing has not been fully elucidated yet, it is undisputable that nutritional state affects it profoundly. The study was focused on speed and quality of wound healing influenced by short-lasting oral administration of omega-3 and omega-6 polyunsaturated fatty acids. Young Wistar rats received by orogastric tube either 20% fat emulsion (experimental groups E and F differed by ratio between omega-3:omega-6:omega-9 polyunsaturated fatty acids) or water (control group C). After 7 days, skin wound on back was performed and emulsion or water application continued for another week. Blood and tissue samples were obtained during experiment termination. Plasmatic levels of fatty acids, 4-hydroxy-2-nonenal and oxidative stress both in plasma and in wound tissue were examined. Speed and quality of wound healing were assessed by digital planimetry and histological examination. Results were statistically evaluated by non-parametric tests. Significant changes of fatty acids plasmatic levels were observed in animals in experimental groups as well as better ability of their plasma and tissues to cope with oxidative stress. Short-lasting administration of certain ratio of polyunsaturated fatty acids positively affects skin wound healing.
Návaznosti
| MUNI/A/0910/2017, interní kód MU |
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| MUNI/A/1157/2017, interní kód MU |
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