Uric Acid and Xanthine Levels in Pregnancy Complicated by
Gestational Diabetes MellitusThe Effect on Adverse Pregnancy
Outcomes

J 2018

Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes

PLESKAČOVÁ, Anna, Vendula BARTÁKOVÁ, Katarína CHALÁSOVÁ, Lukáš PÁCAL, Kateřina KAŇKOVÁ et. al.

Základní údaje

Originální název

Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes

Autoři

PLESKAČOVÁ, Anna (203 Česká republika, domácí), Vendula BARTÁKOVÁ (203 Česká republika, domácí), Katarína CHALÁSOVÁ (703 Slovensko, domácí), Lukáš PÁCAL (203 Česká republika, domácí), Kateřina KAŇKOVÁ (203 Česká republika, domácí) a Josef TOMANDL (203 Česká republika, garant, domácí)

Vydání

International Journal of Molecular Sciences, Basel, MDPI AG, 2018, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.183

Kód RIV

RIV/00216224:14110/18:00106957

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/ijms19113696

UT WoS

000451528500411

Klíčová slova anglicky

uric acid; uricemia; xanthine; gestational diabetes mellitus; pregnancy; adverse perinatal outcomes

Štítky

14110512, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 2. 2019 15:49, Soňa Böhmová

Anotace

V originále

Uric acid (UA) levels are associated with many diseases including those related to lifestyle. The aim of this study was to evaluate the influence of clinical and anthropometric parameters on UA and xanthine (X) levels during pregnancy and postpartum in women with physiological pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM), and to evaluate their impact on adverse perinatal outcomes. A total of 143 participants were included. Analyte levels were determined by HPLC with ultraviolet detection (HPLC-UV). Several single-nucleotide polymorphisms (SNPs) in UA transporters were genotyped using commercial assays. UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. X levels were higher in the GDM group during pregnancy and also postpartum. Positive correlations between UA and X levels with body mass index (BMI) and glycemia levels were found. Gestational age at delivery was negatively correlated with UA and X levels postpartum. Postpartum X levels were significantly higher in women who underwent caesarean sections. Our data support a possible link between increased UA levels and a high-risk GDM subtype. UA levels were higher among women whose glucose tolerance was severely disturbed. Mid-gestational UA and X levels were not linked to adverse perinatal outcomes.

Návaznosti

MUNI/A/0910/2017, interní kód MU

Název: Studium molekulární podstaty vybraných patologických stavů a onemocnění (Akronym: stumopo)

Investor: Masarykova univerzita, Studium molekulární podstaty vybraných patologických stavů a onemocnění, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

NV16-28040A, projekt VaV

Název: Dlouhodobé dopady gestačního diabetes mellitus pro metabolické zdraví žen časně postpartum: význam nových diagnostických kritérií

Citovat

PLESKAČOVÁ, Anna, Vendula BARTÁKOVÁ, Katarína CHALÁSOVÁ, Lukáš PÁCAL, Kateřina KAŇKOVÁ a Josef TOMANDL. Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes. International Journal of Molecular Sciences. Basel: MDPI AG, 2018, roč. 19, č. 11, s. 1-13. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19113696.

@article{1480138,
   author = {Pleskačová, Anna and Bartáková, Vendula and Chalásová, Katarína and Pácal, Lukáš and Kaňková, Kateřina and Tomandl, Josef},
   article_location = {Basel},
   article_number = {11},
   doi = {http://dx.doi.org/10.3390/ijms19113696},
   keywords = {uric acid; uricemia; xanthine; gestational diabetes mellitus; pregnancy; adverse perinatal outcomes},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes},
   volume = {19},
   year = {2018}
}

TY  - JOUR
ID  - 1480138
AU  - Pleskačová, Anna - Bartáková, Vendula - Chalásová, Katarína - Pácal, Lukáš - Kaňková, Kateřina - Tomandl, Josef
PY  - 2018
TI  - Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes
JF  - International Journal of Molecular Sciences
VL  - 19
IS  - 11
SP  - 1-13
EP  - 1-13
PB  - MDPI AG
SN  - 14220067
KW  - uric acid
KW  - uricemia
KW  - xanthine
KW  - gestational diabetes mellitus
KW  - pregnancy
KW  - adverse perinatal outcomes
N2  - Uric acid (UA) levels are associated with many diseases including those related to lifestyle. The aim of this study was to evaluate the influence of clinical and anthropometric parameters on UA and xanthine (X) levels during pregnancy and postpartum in women with physiological pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM), and to evaluate their impact on adverse perinatal outcomes. A total of 143 participants were included. Analyte levels were determined by HPLC with ultraviolet detection (HPLC-UV). Several single-nucleotide polymorphisms (SNPs) in UA transporters were genotyped using commercial assays. UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. X levels were higher in the GDM group during pregnancy and also postpartum. Positive correlations between UA and X levels with body mass index (BMI) and glycemia levels were found. Gestational age at delivery was negatively correlated with UA and X levels postpartum. Postpartum X levels were significantly higher in women who underwent caesarean sections. Our data support a possible link between increased UA levels and a high-risk GDM subtype. UA levels were higher among women whose glucose tolerance was severely disturbed. Mid-gestational UA and X levels were not linked to adverse perinatal outcomes.
ER  -

PLESKAČOVÁ, Anna, Vendula BARTÁKOVÁ, Katarína CHALÁSOVÁ, Lukáš PÁCAL, Kateřina KAŇKOVÁ a Josef TOMANDL. Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes. \textit{International Journal of Molecular Sciences}. Basel: MDPI AG, 2018, roč.~19, č.~11, s.~1-13. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19113696.

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