2018
Capillary Electrophoretic Method with Fluorescence Detection as a Promising Tool for Screening of Beta-Secretase Inhibitors
ŘEMÍNEK, Roman; Jan SCHEJBAL and Zdeněk GLATZBasic information
Original name
Capillary Electrophoretic Method with Fluorescence Detection as a Promising Tool for Screening of Beta-Secretase Inhibitors
Name in Czech
Kapilárně elektroforetická metoda s fluorescenční detekcí pro screening inhibitorů beta-sekretázy
Authors
ŘEMÍNEK, Roman; Jan SCHEJBAL and Zdeněk GLATZ
Edition
15th International Interdisciplinary Meeting on Bioanalysis CECE 2018. 2018
Other information
Language
English
Type of outcome
Conference abstract
Field of Study
10609 Biochemical research methods
Country of publisher
Czech Republic
Confidentiality degree
is not subject to a state or trade secret
References:
Organization unit
Faculty of Science
Keywords (in Czech)
kapilární elektroforéza, Alzheimerova choroba, beta-sekretáza, inhibice, fluorescenční detekce, FRET
Keywords in English
capillary electrophoresis, Alzheimer's disease, beta-secretase, inhibition, fluorescent detection, FRET
Tags
International impact, Reviewed
Changed: 3/1/2019 09:51, Ing. Mgr. Roman Řemínek, Ph.D.
V originále
Alzheimer’s disease (AD) represents the most common cause of dementia. According to amyloid cascade hypothesis, pathogenesis of the disease could be slowed down or even stopped by inhibition of beta-secretase (BACE). Capillary electrophoretic (CE) methods are regarded as a promising tool for enzyme assays. A CE method with fluorescence detection for screening of potential BACE inhibitors was therefore introduced.
In Czech
Byla zavedena metoda pro testování inhibitorů beta-sekretázy pomocí kapilární elektroforézy s fluorescenční detekcí.
Links
| GA16-06106S, research and development project |
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