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@article{1482484, author = {Vašíčková, Kateřina and Moráň, Lukáš and Gurín, Dominik and Vaňhara, Petr}, article_location = {Heidelberg}, article_number = {3}, doi = {http://dx.doi.org/10.1007/s00441-018-2888-9}, keywords = {Ovarian surface epithelium; Endoplasmic reticulum stress; Unfolded protein response; Senescence; Tauroursodeoxycholic acid}, language = {eng}, issn = {0302-766X}, journal = {CELL AND TISSUE RESEARCH}, title = {Alleviation of endoplasmic reticulum stress by tauroursodeoxycholic acid delays senescence of mouse ovarian surface epithelium}, url = {https://link.springer.com/article/10.1007%2Fs00441-018-2888-9}, volume = {374}, year = {2018} }
TY - JOUR ID - 1482484 AU - Vašíčková, Kateřina - Moráň, Lukáš - Gurín, Dominik - Vaňhara, Petr PY - 2018 TI - Alleviation of endoplasmic reticulum stress by tauroursodeoxycholic acid delays senescence of mouse ovarian surface epithelium JF - CELL AND TISSUE RESEARCH VL - 374 IS - 3 SP - 643-652 EP - 643-652 PB - Springer Verlag SN - 0302766X KW - Ovarian surface epithelium KW - Endoplasmic reticulum stress KW - Unfolded protein response KW - Senescence KW - Tauroursodeoxycholic acid UR - https://link.springer.com/article/10.1007%2Fs00441-018-2888-9 N2 - Ovarian surface epithelium (OSE) forms a single layer of mostly cuboidal cells on surface of mammalian ovaries that is inherently exposed to cell stress evoked by tissue damage every ovulation and declines morphologically after menopause. Endoplasmic reticulum (ER) is a principal cell organelle involved in proteosynthesis, but also integrating various stress signals. ER stress evokes a conserved signaling pathway, the unfolded protein response (UPR), leading to cell death or adaptation to stress conditions. In this work, we document that mouse OSE suffers from ER stress during replicative senescence in vitro, develops abnormalities in ER and initiates UPR. Attenuation of ER stress in senescent OSE by tauroursodeoxycholic acid (TUDCA) reconditions ER architecture and leads to delayed onset of senescence. In summary, we show for the first time a mutual molecular link between ER stress response and replicative senescence leading to phenotypic changes of non-malignant ovarian surface epithelium. ER -
VAŠÍČKOVÁ, Kateřina, Lukáš MORÁŇ, Dominik GURÍN a Petr VAŇHARA. Alleviation of endoplasmic reticulum stress by tauroursodeoxycholic acid delays senescence of mouse ovarian surface epithelium. \textit{CELL AND TISSUE RESEARCH}. Heidelberg: Springer Verlag, 2018, roč.~374, č.~3, s.~643-652. ISSN~0302-766X. Dostupné z: https://dx.doi.org/10.1007/s00441-018-2888-9.
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