SEDLAŘÍKOVÁ, Lenka, Božena BOLLOVÁ, Lenka RADOVÁ, Lucie BROŽOVÁ, Jiří JARKOVSKÝ, Martina ALMÁŠI, Miroslav PENKA, Petr KUGLÍK, Viera SANDECKÁ, Martin ŠTORK, Luděk POUR a Sabina ŠEVČÍKOVÁ. Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies. Hematological Oncology. MALDEN, USA: WILEY-BLACKWELL, 2018, roč. 36, č. 5, s. 786-791. ISSN 0278-0232. Dostupné z: https://dx.doi.org/10.1002/hon.2554. |
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@article{1482886, author = {Sedlaříková, Lenka and Bollová, Božena and Radová, Lenka and Brožová, Lucie and Jarkovský, Jiří and Almáši, Martina and Penka, Miroslav and Kuglík, Petr and Sandecká, Viera and Štork, Martin and Pour, Luděk and Ševčíková, Sabina}, article_location = {MALDEN, USA}, article_number = {5}, doi = {http://dx.doi.org/10.1002/hon.2554}, keywords = {biomarker; long noncoding RNA; monoclonal gammopathy of undetermined significance; multiple myeloma; qPCR}, language = {eng}, issn = {0278-0232}, journal = {Hematological Oncology}, title = {Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies}, volume = {36}, year = {2018} }
TY - JOUR ID - 1482886 AU - Sedlaříková, Lenka - Bollová, Božena - Radová, Lenka - Brožová, Lucie - Jarkovský, Jiří - Almáši, Martina - Penka, Miroslav - Kuglík, Petr - Sandecká, Viera - Štork, Martin - Pour, Luděk - Ševčíková, Sabina PY - 2018 TI - Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies JF - Hematological Oncology VL - 36 IS - 5 SP - 786-791 EP - 786-791 PB - WILEY-BLACKWELL SN - 02780232 KW - biomarker KW - long noncoding RNA KW - monoclonal gammopathy of undetermined significance KW - multiple myeloma KW - qPCR N2 - Multiple myeloma is the second most common hematological malignancy characterized by focal lesions of malignant plasma cells in the bone marrow. These lesions contain subclones that directly influence survival of patients. Bone marrow biopsies are single-site biopsies and thus cannot contain all information about the tumor. In contrast, liquid biopsies analyze circulating cells and molecules that are secreted from all sites of the tumor. Long noncoding RNA molecules are one class of these molecules. We performed a two-phase biomarker study investigating lncRNA expression profiles in exosomes of peripheral blood serum of newly diagnosed multiple myeloma (MM) patients, monoclonal gammopathy of undetermined significance (MGUS) patients in comparison with healthy donors (HD). Surprisingly, this analysis revealed dysregulation of only one exosomal lncRNA PRINS in MM vs HD. Overall, MM and MGUS patients were distinguished from HD with sensitivity of 84.9% and specificity of 83.3%. Our study suggests a possible diagnostic role for exosomal lncRNA PRINS in monoclonal gammopathies patients. ER -
SEDLAŘÍKOVÁ, Lenka, Božena BOLLOVÁ, Lenka RADOVÁ, Lucie BROŽOVÁ, Jiří JARKOVSKÝ, Martina ALMÁŠI, Miroslav PENKA, Petr KUGLÍK, Viera SANDECKÁ, Martin ŠTORK, Luděk POUR a Sabina ŠEVČÍKOVÁ. Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies. \textit{Hematological Oncology}. MALDEN, USA: WILEY-BLACKWELL, 2018, roč.~36, č.~5, s.~786-791. ISSN~0278-0232. Dostupné z: https://dx.doi.org/10.1002/hon.2554.
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