Circulating exosomal long noncoding RNA PRINS-First findings in
monoclonal gammopathies

J 2018

Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies

SEDLAŘÍKOVÁ, Lenka, Božena BOLLOVÁ, Lenka RADOVÁ, Lucie BROŽOVÁ, Jiří JARKOVSKÝ et. al.

Základní údaje

Originální název

Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies

Autoři

SEDLAŘÍKOVÁ, Lenka (203 Česká republika, domácí), Božena BOLLOVÁ (703 Slovensko, domácí), Lenka RADOVÁ (203 Česká republika, domácí), Lucie BROŽOVÁ (203 Česká republika, domácí), Jiří JARKOVSKÝ (203 Česká republika, domácí), Martina ALMÁŠI (203 Česká republika), Miroslav PENKA (203 Česká republika), Petr KUGLÍK (203 Česká republika, domácí), Viera SANDECKÁ (703 Slovensko), Martin ŠTORK (203 Česká republika), Luděk POUR (203 Česká republika) a Sabina ŠEVČÍKOVÁ (203 Česká republika, garant, domácí)

Vydání

Hematological Oncology, MALDEN, USA, WILEY-BLACKWELL, 2018, 0278-0232

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30205 Hematology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.439

Kód RIV

RIV/00216224:14110/18:00106959

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/hon.2554

UT WoS

000452625700009

Klíčová slova anglicky

biomarker; long noncoding RNA; monoclonal gammopathy of undetermined significance; multiple myeloma; qPCR

Štítky

14110518, 14119612, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 3. 2019 12:17, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Multiple myeloma is the second most common hematological malignancy characterized by focal lesions of malignant plasma cells in the bone marrow. These lesions contain subclones that directly influence survival of patients. Bone marrow biopsies are single-site biopsies and thus cannot contain all information about the tumor. In contrast, liquid biopsies analyze circulating cells and molecules that are secreted from all sites of the tumor. Long noncoding RNA molecules are one class of these molecules. We performed a two-phase biomarker study investigating lncRNA expression profiles in exosomes of peripheral blood serum of newly diagnosed multiple myeloma (MM) patients, monoclonal gammopathy of undetermined significance (MGUS) patients in comparison with healthy donors (HD). Surprisingly, this analysis revealed dysregulation of only one exosomal lncRNA PRINS in MM vs HD. Overall, MM and MGUS patients were distinguished from HD with sensitivity of 84.9% and specificity of 83.3%. Our study suggests a possible diagnostic role for exosomal lncRNA PRINS in monoclonal gammopathies patients.

Návaznosti

NV15-29508A, projekt VaV

Název: Cirkulující nukleové kyseliny jako markery progrese mnohočetného myelomu

Citovat

SEDLAŘÍKOVÁ, Lenka, Božena BOLLOVÁ, Lenka RADOVÁ, Lucie BROŽOVÁ, Jiří JARKOVSKÝ, Martina ALMÁŠI, Miroslav PENKA, Petr KUGLÍK, Viera SANDECKÁ, Martin ŠTORK, Luděk POUR a Sabina ŠEVČÍKOVÁ. Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies. Hematological Oncology. MALDEN, USA: WILEY-BLACKWELL, 2018, roč. 36, č. 5, s. 786-791. ISSN 0278-0232. Dostupné z: https://dx.doi.org/10.1002/hon.2554.

@article{1482886,
   author = {Sedlaříková, Lenka and Bollová, Božena and Radová, Lenka and Brožová, Lucie and Jarkovský, Jiří and Almáši, Martina and Penka, Miroslav and Kuglík, Petr and Sandecká, Viera and Štork, Martin and Pour, Luděk and Ševčíková, Sabina},
   article_location = {MALDEN, USA},
   article_number = {5},
   doi = {http://dx.doi.org/10.1002/hon.2554},
   keywords = {biomarker; long noncoding RNA; monoclonal gammopathy of undetermined significance; multiple myeloma; qPCR},
   language = {eng},
   issn = {0278-0232},
   journal = {Hematological Oncology},
   title = {Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies},
   volume = {36},
   year = {2018}
}

TY  - JOUR
ID  - 1482886
AU  - Sedlaříková, Lenka - Bollová, Božena - Radová, Lenka - Brožová, Lucie - Jarkovský, Jiří - Almáši, Martina - Penka, Miroslav - Kuglík, Petr - Sandecká, Viera - Štork, Martin - Pour, Luděk - Ševčíková, Sabina
PY  - 2018
TI  - Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies
JF  - Hematological Oncology
VL  - 36
IS  - 5
SP  - 786-791
EP  - 786-791
PB  - WILEY-BLACKWELL
SN  - 02780232
KW  - biomarker
KW  - long noncoding RNA
KW  - monoclonal gammopathy of undetermined significance
KW  - multiple myeloma
KW  - qPCR
N2  - Multiple myeloma is the second most common hematological malignancy characterized by focal lesions of malignant plasma cells in the bone marrow. These lesions contain subclones that directly influence survival of patients. Bone marrow biopsies are single-site biopsies and thus cannot contain all information about the tumor. In contrast, liquid biopsies analyze circulating cells and molecules that are secreted from all sites of the tumor. Long noncoding RNA molecules are one class of these molecules. We performed a two-phase biomarker study investigating lncRNA expression profiles in exosomes of peripheral blood serum of newly diagnosed multiple myeloma (MM) patients, monoclonal gammopathy of undetermined significance (MGUS) patients in comparison with healthy donors (HD). Surprisingly, this analysis revealed dysregulation of only one exosomal lncRNA PRINS in MM vs HD. Overall, MM and MGUS patients were distinguished from HD with sensitivity of 84.9% and specificity of 83.3%. Our study suggests a possible diagnostic role for exosomal lncRNA PRINS in monoclonal gammopathies patients.
ER  -

SEDLAŘÍKOVÁ, Lenka, Božena BOLLOVÁ, Lenka RADOVÁ, Lucie BROŽOVÁ, Jiří JARKOVSKÝ, Martina ALMÁŠI, Miroslav PENKA, Petr KUGLÍK, Viera SANDECKÁ, Martin ŠTORK, Luděk POUR a Sabina ŠEVČÍKOVÁ. Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies. \textit{Hematological Oncology}. MALDEN, USA: WILEY-BLACKWELL, 2018, roč.~36, č.~5, s.~786-791. ISSN~0278-0232. Dostupné z: https://dx.doi.org/10.1002/hon.2554.

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