Human White Adipose Tissue Metabolome: Current Perspective

J 2018

Human White Adipose Tissue Metabolome: Current Perspective

KUČERA, Jan, Zdeněk SPÁČIL, David FRIEDECKÝ, Jan NOVÁK, Matej PEKAŘ et. al.

Základní údaje

Originální název

Human White Adipose Tissue Metabolome: Current Perspective

Autoři

KUČERA, Jan (203 Česká republika, domácí), Zdeněk SPÁČIL (203 Česká republika, domácí), David FRIEDECKÝ (203 Česká republika), Jan NOVÁK (203 Česká republika, domácí), Matej PEKAŘ (703 Slovensko, domácí) a Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, garant, domácí)

Vydání

OBESITY, HOBOKEN, WILEY, 2018, 1930-7381

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30308 Nutrition, Dietetics

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.969

Kód RIV

RIV/00216224:14310/18:00105235

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1002/oby.22336

UT WoS

000450678700011

Klíčová slova anglicky

OBESITY; ACID; ASSOCIATION; LIPIDOMICS; DISCOVERY; PROFILES; HEALTHY

Štítky

14110515, 14110518, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 1. 2019 20:54, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Objective Interest in metabolites produced by adipose tissue has increased substantially in the past several decades. Previously regarded as an inert energy storage depot, adipose tissue is now viewed as a complex metabolically active organ with considerable impact on human health. The emerging field of mass spectrometry-based metabolomics presents a powerful tool for the study of processes in complex biological matrices including adipose tissue. Results A large number of structurally distinct metabolites can be analyzed to facilitate the investigation of differences between physiological and pathophysiological metabolic profiles associated with adipose tissue. Understanding the molecular basis of adipose tissue regulation can thereby provide insight into the monitoring of obesity-related metabolic disorders and lead to the development of novel diagnostic and prognostic biomarkers. Conclusions This review provides the current state of knowledge, recent progress, and critical evaluation of metabolomics approaches in the context of white adipose tissue and obesity. An overview of basic principles and resources describing individual groups of metabolites analyzed in white adipose tissue and biological fluids is given. The focus is on metabolites that can serve as reliable biomarkers indicative of metabolic alterations associated with obesity.

Návaznosti

CZ.02.1.01/0.0/0.0/16_013/0001761, interní kód MU

Název: RECETOX RI - OP VVV (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI - OP VVV, PO 1 Posilování kapacit pro kvalitní výzkum

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

KUČERA, Jan, Zdeněk SPÁČIL, David FRIEDECKÝ, Jan NOVÁK, Matej PEKAŘ a Julie BIENERTOVÁ VAŠKŮ. Human White Adipose Tissue Metabolome: Current Perspective. OBESITY. HOBOKEN: WILEY, 2018, roč. 26, č. 12, s. 1870-1878. ISSN 1930-7381. Dostupné z: https://dx.doi.org/10.1002/oby.22336.

@article{1483136,
   author = {Kučera, Jan and Spáčil, Zdeněk and Friedecký, David and Novák, Jan and Pekař, Matej and Bienertová Vašků, Julie},
   article_location = {HOBOKEN},
   article_number = {12},
   doi = {http://dx.doi.org/10.1002/oby.22336},
   keywords = {OBESITY; ACID; ASSOCIATION; LIPIDOMICS; DISCOVERY; PROFILES; HEALTHY},
   language = {eng},
   issn = {1930-7381},
   journal = {OBESITY},
   title = {Human White Adipose Tissue Metabolome: Current Perspective},
   url = {https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22336},
   volume = {26},
   year = {2018}
}

TY  - JOUR
ID  - 1483136
AU  - Kučera, Jan - Spáčil, Zdeněk - Friedecký, David - Novák, Jan - Pekař, Matej - Bienertová Vašků, Julie
PY  - 2018
TI  - Human White Adipose Tissue Metabolome: Current Perspective
JF  - OBESITY
VL  - 26
IS  - 12
SP  - 1870-1878
EP  - 1870-1878
PB  - WILEY
SN  - 19307381
KW  - OBESITY
KW  - ACID
KW  - ASSOCIATION
KW  - LIPIDOMICS
KW  - DISCOVERY
KW  - PROFILES
KW  - HEALTHY
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22336
L2  - https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22336
N2  - Objective Interest in metabolites produced by adipose tissue has increased substantially in the past several decades. Previously regarded as an inert energy storage depot, adipose tissue is now viewed as a complex metabolically active organ with considerable impact on human health. The emerging field of mass spectrometry-based metabolomics presents a powerful tool for the study of processes in complex biological matrices including adipose tissue. Results A large number of structurally distinct metabolites can be analyzed to facilitate the investigation of differences between physiological and pathophysiological metabolic profiles associated with adipose tissue. Understanding the molecular basis of adipose tissue regulation can thereby provide insight into the monitoring of obesity-related metabolic disorders and lead to the development of novel diagnostic and prognostic biomarkers. Conclusions This review provides the current state of knowledge, recent progress, and critical evaluation of metabolomics approaches in the context of white adipose tissue and obesity. An overview of basic principles and resources describing individual groups of metabolites analyzed in white adipose tissue and biological fluids is given. The focus is on metabolites that can serve as reliable biomarkers indicative of metabolic alterations associated with obesity.
ER  -

KUČERA, Jan, Zdeněk SPÁČIL, David FRIEDECKÝ, Jan NOVÁK, Matej PEKAŘ a Julie BIENERTOVÁ VAŠKŮ. Human White Adipose Tissue Metabolome: Current Perspective. \textit{OBESITY}. HOBOKEN: WILEY, 2018, roč.~26, č.~12, s.~1870-1878. ISSN~1930-7381. Dostupné z: https://dx.doi.org/10.1002/oby.22336.

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