2018
Xylylene-Glycoluril Macrocycles
LÍZAL, Tomáš a Vladimír ŠINDELÁŘZákladní údaje
Originální název
Xylylene-Glycoluril Macrocycles
Autoři
LÍZAL, Tomáš a Vladimír ŠINDELÁŘ
Vydání
53rd Advances in Organic, Bioorganic and Pharmaceutical Chemistry "Liblice 2018" 2-4 November 2018, Lázně Bělohrad, Czech Republic, 2018
Další údaje
Typ výsledku
Prezentace na konferencích
Utajení
není předmětem státního či obchodního tajemství
Organizační jednotka
Přírodovědecká fakulta
Příznaky
Mezinárodní význam
Změněno: 7. 1. 2019 16:49, Mgr. Tomáš Lízal, Ph.D.
Anotace
V originále
Bambusurils1 are potent anion receptors that are synthetized by acidic condensation of 2,4-disubstituted glycolurils and formaldehyde. They were used to detect and quantify anions in a complex mixture by NMR2. In order to allow anion sensing by UV-VIS spectroscopy, we designed a new bambusuril derivative incorporating aromatic groups in its structure. Here we report preparation of xylylene-glycoluril macrocycles. Inspired by work of prof. Shimizu on aromatic-urea macrocycles3, we employed basic synthetic conditions instead of the acid catalyzed condensation. It afforded us with macrocycles of various sizes (Fig. 1), which were separated by reverse-phase flash chromatography. The conformational behavior of separated isomers of two-membered macrocycles were studied by temperature dependent NMR. The three-membered macrocycle was observed in a gas phase to bind anions.
Návaznosti
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