Are the subthalamic nucleus, internal globus pallidus and
thalamus involved in thinking?

J 2018

Are the subthalamic nucleus, internal globus pallidus and thalamus involved in thinking?

MINKS, Eduard, Pavel JURÁK, Jan CHLÁDEK, Alexandra MINKSOVÁ, Zuzana HUMMELOVÁ et. al.

Basic information

Original name

Are the subthalamic nucleus, internal globus pallidus and thalamus involved in thinking?

Authors

MINKS, Eduard (203 Czech Republic, guarantor, belonging to the institution), Pavel JURÁK (203 Czech Republic), Jan CHLÁDEK (203 Czech Republic, belonging to the institution), Alexandra MINKSOVÁ (203 Czech Republic), Zuzana HUMMELOVÁ (203 Czech Republic, belonging to the institution), Josef HALÁMEK (203 Czech Republic), Jan CHRASTINA (203 Czech Republic, belonging to the institution), Petra OVESNÁ (203 Czech Republic, belonging to the institution) and Martin BAREŠ (203 Czech Republic, belonging to the institution)

Edition

Basal Ganglia, Munich, Elsevier GmbH, 2018, 2210-5336

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/18:00105353

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.baga.2018.07.004

UT WoS

000452901900003

Keywords in English

Mismatch negativity; P300; Subthalamic nucleus; Internal globus pallidus; Anterior thalamic nucleus; Ventral intermediate nucleus of the thalamus

Abstract

V originále

Introduction: The aim was to compare event-related potentials and event-related de/synchronisations between the P300 and mismatch negativity paradigms, both recorded in the subcortical structures and thus illustrate conscious cognition process in these structures. The second aim was to uncover if the mismatch negativity can be found in subcortical structures. Methods: We included patients with Parkinson's disease, generalised dystonia, essential tremor and epilepsy in the deep brain stimulation program. The electrodes were implanted into the subthalamic nucleus, internal globus pallidus, then in the anterior and ventral intermediate nucleus of the thalamus bilaterally. We were interested in local oscillations. Results: We found a significant P300 - mismatch negativity difference at 250-400 ms latency in the basal ganglia and thalamus in event-related potentials in 7 out of 8 patients. There was also a significant difference in eventrelated de/synchronisations at 500-1500 ms latency in 7 out of 8 patients in the beta band and desynchronisation in the subthalamic nucleus plus the internal globus pallidus and synchronisation in the anterior thalamic nucleus. When the mismatch negativity protocol was processed we found a significant outcome in event-related potentials (100-250 ms latency) in the internal globus pallidus and the ventral intermediate nucleus of the thalamus in 4 out of 6 patients. Conclusion: The results suggest that the subthalamic nucleus, internal globus pallidus and maybe also the thalamus are involved firstly in the subconscious cognitive process 100-250 ms after the stimuli, then in the conscious cognitive processes at the level of the afferent information processing network at 250-400 ms and finally they affect conscious cognitive activity at a time of large brain neuronal network 500-1500 ms after stimuli.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

NT13437, research and development project

Name: Mozeček, kognitivní dysfunkce a mechanismy kontroly pohybu a odhadu času u dystonie a schizofrenie.

Citovat

MINKS, Eduard, Pavel JURÁK, Jan CHLÁDEK, Alexandra MINKSOVÁ, Zuzana HUMMELOVÁ, Josef HALÁMEK, Jan CHRASTINA, Petra OVESNÁ and Martin BAREŠ. Are the subthalamic nucleus, internal globus pallidus and thalamus involved in thinking? Basal Ganglia. Munich: Elsevier GmbH, 2018, vol. 14, NOV 2018, p. 22-30. ISSN 2210-5336. Available from: https://dx.doi.org/10.1016/j.baga.2018.07.004.

@article{1484638,
   author = {Minks, Eduard and Jurák, Pavel and Chládek, Jan and Minksová, Alexandra and Hummelová, Zuzana and Halámek, Josef and Chrastina, Jan and Ovesná, Petra and Bareš, Martin},
   article_location = {Munich},
   article_number = {NOV 2018},
   doi = {http://dx.doi.org/10.1016/j.baga.2018.07.004},
   keywords = {Mismatch negativity; P300; Subthalamic nucleus; Internal globus pallidus; Anterior thalamic nucleus; Ventral intermediate nucleus of the thalamus},
   language = {eng},
   issn = {2210-5336},
   journal = {Basal Ganglia},
   title = {Are the subthalamic nucleus, internal globus pallidus and thalamus involved in thinking?},
   volume = {14},
   year = {2018}
}

TY  - JOUR
ID  - 1484638
AU  - Minks, Eduard - Jurák, Pavel - Chládek, Jan - Minksová, Alexandra - Hummelová, Zuzana - Halámek, Josef - Chrastina, Jan - Ovesná, Petra - Bareš, Martin
PY  - 2018
TI  - Are the subthalamic nucleus, internal globus pallidus and thalamus involved in thinking?
JF  - Basal Ganglia
VL  - 14
IS  - NOV 2018
SP  - 22-30
EP  - 22-30
PB  - Elsevier GmbH
SN  - 22105336
KW  - Mismatch negativity
KW  - P300
KW  - Subthalamic nucleus
KW  - Internal globus pallidus
KW  - Anterior thalamic nucleus
KW  - Ventral intermediate nucleus of the thalamus
N2  - Introduction: The aim was to compare event-related potentials and event-related de/synchronisations between the P300 and mismatch negativity paradigms, both recorded in the subcortical structures and thus illustrate conscious cognition process in these structures. The second aim was to uncover if the mismatch negativity can be found in subcortical structures. Methods: We included patients with Parkinson's disease, generalised dystonia, essential tremor and epilepsy in the deep brain stimulation program. The electrodes were implanted into the subthalamic nucleus, internal globus pallidus, then in the anterior and ventral intermediate nucleus of the thalamus bilaterally. We were interested in local oscillations. Results: We found a significant P300 - mismatch negativity difference at 250-400 ms latency in the basal ganglia and thalamus in event-related potentials in 7 out of 8 patients. There was also a significant difference in eventrelated de/synchronisations at 500-1500 ms latency in 7 out of 8 patients in the beta band and desynchronisation in the subthalamic nucleus plus the internal globus pallidus and synchronisation in the anterior thalamic nucleus. When the mismatch negativity protocol was processed we found a significant outcome in event-related potentials (100-250 ms latency) in the internal globus pallidus and the ventral intermediate nucleus of the thalamus in 4 out of 6 patients. Conclusion: The results suggest that the subthalamic nucleus, internal globus pallidus and maybe also the thalamus are involved firstly in the subconscious cognitive process 100-250 ms after the stimuli, then in the conscious cognitive processes at the level of the afferent information processing network at 250-400 ms and finally they affect conscious cognitive activity at a time of large brain neuronal network 500-1500 ms after stimuli.
ER  -

MINKS, Eduard, Pavel JURÁK, Jan CHLÁDEK, Alexandra MINKSOVÁ, Zuzana HUMMELOVÁ, Josef HALÁMEK, Jan CHRASTINA, Petra OVESNÁ and Martin BAREŠ. Are the subthalamic nucleus, internal globus pallidus and thalamus involved in thinking? \textit{Basal Ganglia}. Munich: Elsevier GmbH, 2018, vol.~14, NOV 2018, p.~22-30. ISSN~2210-5336. Available from: https://dx.doi.org/10.1016/j.baga.2018.07.004.

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