Analysis of physiological parameters of Desulfovibrio strains
from individuals with colitis

J 2018

Analysis of physiological parameters of Desulfovibrio strains from individuals with colitis

KUSHKEVYCH, Ivan, Dani DORDEVIĆ a Peter KOLLÁR

Základní údaje

Originální název

Analysis of physiological parameters of Desulfovibrio strains from individuals with colitis

Autoři

KUSHKEVYCH, Ivan (804 Ukrajina, garant, domácí), Dani DORDEVIĆ (203 Česká republika) a Peter KOLLÁR (203 Česká republika)

Vydání

Open Life Sciences formerly Central European Journal of Biology, 2018, 2391-5412

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10606 Microbiology

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 0.504

Kód RIV

RIV/00216224:14310/18:00105404

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1515/biol-2018-0057

UT WoS

000455227700001

Klíčová slova anglicky

inflammatory bowel disease; ulcerative; colitis; sulfate-reducing bacteria; Desulfovibrio; hydrogen; sulfide; component analysis

Změněno: 2. 5. 2019 16:24, Mgr. Tereza Miškechová

Anotace

V originále

Intestinal sulfate-reducing bacteria are often isolated from patients with inflammatory bowel disease, including ulcerative colitis, and can be involved in the development of gut inflammation. A comparison of the metabolism of intestinal sulfate-reducing bacteria isolated from individuals with colitis and healthy controls using statistical analysis has never been studied and described before. The aim of our research was to evaluate the parameters of dissimilatory sulfate reduction in Desulfovibrio species that were isolated from the feces of healthy objects and individuals with colitis. Principal component analysis indicates that the strains that were isolated from individuals with colitis grouped in the same cluster by biomass accumulation and sulfide production, same as the strains isolated from healthy individuals. Sulfate and lactate consumption measured over time showed negative correlation (Pearson correlations, p<0.01), healthy: -0.760; colitis: -0.770; healthy: -0.828; colitis: -0.847, respectively. The calculated linear regression (R2) was lower in biomass accumulation and hydrogen sulfide production, 0.531; 0.625 respectively. Thus, biomass accumulation and sulfide production, together with measured kinetic parameters play an important factor in bowel inflammation, including ulcerative colitis. Additionally, acetate production can also synergize with H2S, while sulfate consumption and lactate oxidation likely represent minor factors in bowel disease.

Citovat

KUSHKEVYCH, Ivan, Dani DORDEVIĆ a Peter KOLLÁR. Analysis of physiological parameters of Desulfovibrio strains from individuals with colitis. Open Life Sciences formerly Central European Journal of Biology. 2018, roč. 13, č. 1, s. 481-488. ISSN 2391-5412. Dostupné z: https://dx.doi.org/10.1515/biol-2018-0057.

@article{1485359,
   author = {Kushkevych, Ivan and Dordević, Dani and Kollár, Peter},
   article_number = {1},
   doi = {http://dx.doi.org/10.1515/biol-2018-0057},
   keywords = {inflammatory bowel disease; ulcerative; colitis; sulfate-reducing bacteria; Desulfovibrio; hydrogen; sulfide; component analysis},
   language = {eng},
   issn = {2391-5412},
   journal = {Open Life Sciences formerly Central European Journal of Biology},
   title = {Analysis of physiological parameters of Desulfovibrio strains from individuals with colitis},
   url = {https://www.degruyter.com/view/j/biol.2018.13.issue-1/biol-2018-0057/biol-2018-0057.xml?format=INT},
   volume = {13},
   year = {2018}
}

TY  - JOUR
ID  - 1485359
AU  - Kushkevych, Ivan - Dordević, Dani - Kollár, Peter
PY  - 2018
TI  - Analysis of physiological parameters of Desulfovibrio strains from individuals with colitis
JF  - Open Life Sciences formerly Central European Journal of Biology
VL  - 13
IS  - 1
SP  - 481-488
EP  - 481-488
SN  - 23915412
KW  - inflammatory bowel disease
KW  - ulcerative
KW  - colitis
KW  - sulfate-reducing bacteria
KW  - Desulfovibrio
KW  - hydrogen
KW  - sulfide
KW  - component analysis
UR  - https://www.degruyter.com/view/j/biol.2018.13.issue-1/biol-2018-0057/biol-2018-0057.xml?format=INT
L2  - https://www.degruyter.com/view/j/biol.2018.13.issue-1/biol-2018-0057/biol-2018-0057.xml?format=INT
N2  - Intestinal sulfate-reducing bacteria are often isolated from patients with inflammatory bowel disease, including ulcerative colitis, and can be involved in the development of gut inflammation. A comparison of the metabolism of intestinal sulfate-reducing bacteria isolated from individuals with colitis and healthy controls using statistical analysis has never been studied and described before. The aim of our research was to evaluate the parameters of dissimilatory sulfate reduction in Desulfovibrio species that were isolated from the feces of healthy objects and individuals with colitis. Principal component analysis indicates that the strains that were isolated from individuals with colitis grouped in the same cluster by biomass accumulation and sulfide production, same as the strains isolated from healthy individuals. Sulfate and lactate consumption measured over time showed negative correlation (Pearson correlations, p<0.01), healthy: -0.760; colitis: -0.770; healthy: -0.828; colitis: -0.847, respectively. The calculated linear regression (R2) was lower in biomass accumulation and hydrogen sulfide production, 0.531; 0.625 respectively. Thus, biomass accumulation and sulfide production, together with measured kinetic parameters play an important factor in bowel inflammation, including ulcerative colitis. Additionally, acetate production can also synergize with H2S, while sulfate consumption and lactate oxidation likely represent minor factors in bowel disease.
ER  -

KUSHKEVYCH, Ivan, Dani DORDEVI$\backslash$'C a Peter KOLLÁR. Analysis of physiological parameters of Desulfovibrio strains from individuals with colitis. \textit{Open Life Sciences formerly Central European Journal of Biology}. 2018, roč.~13, č.~1, s.~481-488. ISSN~2391-5412. Dostupné z: https://dx.doi.org/10.1515/biol-2018-0057.

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