Hippocampal involvement in nonpathological deja vu: Subfield
vulnerability rather than temporal lobe epilepsy equivalent

J 2018

Hippocampal involvement in nonpathological deja vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent

PEŠLOVÁ, Eva, Radek MAREČEK, Daniel Joel SHAW, Tomáš KAŠPÁREK, Martin PAIL et. al.

Základní údaje

Originální název

Hippocampal involvement in nonpathological deja vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent

Autoři

PEŠLOVÁ, Eva (203 Česká republika, domácí), Radek MAREČEK (203 Česká republika, domácí), Daniel Joel SHAW (826 Velká Británie a Severní Irsko, domácí), Tomáš KAŠPÁREK (203 Česká republika, domácí), Martin PAIL (203 Česká republika, domácí) a Milan BRÁZDIL (203 Česká republika, garant, domácí)

Vydání

Brain and Behavior, Hoboken, Wiley, 2018, 2162-3279

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.072

Kód RIV

RIV/00216224:14110/18:00105516

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/brb3.996

UT WoS

000438495400021

Klíčová slova anglicky

deja vu; hippocampal subfields; hippocampal vulnerability; mesial temporal lobe epilepsy; schizophrenia

Štítky

14110127, 14110222, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 3. 2019 15:56, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Introduction: Morphological correlates of nonpathological deja vu (DV) have been identified recently within the human brain. Significantly reduced gray matter volume (GMV) within a set of cortical and subcortical regions reported in subjects experiencing DV seems to mirror the distribution of GMV reduction in mesial temporal lobe epilepsy (MTLE) patients but vary in terms of the hippocampus. Another condition associated with hippocampal GMV reduction and DV alike disturbance in memory processing is schizophrenia (SCH). Here, we tested the hypothesis that hippocampal involvement in nonpathological DV resembles more closely the pattern of GMV decrease observed in MTLE compared with that occurring in SCH. Methods: Using automated segmentation of the MRI data we compared the medians of GMV within 12 specific hippocampal subfields in healthy individuals that do (DV+; N = 87) and do not report deja vu experience (DV-; N = 26), and patients with MTLE (N = 47) and SCH (N = 29). By Pearson correlation, we then evaluated the similarity of MTLE and SCH groups to DV+ group with respect to spatial distribution of GMV deviation from DV- group. Results: Significant GMV decrease was found in MTLE group in most of the subfields. There were just trends in the hippocampal GMV decrease found in DV+ or SCH groups. Concerning the spatial distribution of GMV decrease, we revealed statistically significant correlation for the left hippocampus for SCH vs DV+, Otherwise there was no statistically significant correlation. Conclusions: Our findings reveal structural features of hippocampal involvement in nonpathological DV, MTLE, and SCH. Despite our expectations, the pattern of GMV reduction in the DV+ relative to the DV- group does not resemble the pattern observed in MTLE any more than that observed in SCH. The highly similar patterns of the three clinical groups rather suggest an increased vulnerability of certain hippocampal subfields; namely, Cornu Ammonis (CA)4, CA3, dentate gyrus granular cell layer (GC-DG), hippocampal-amygdaloid transition area (HATA) and subiculum.

Návaznosti

LM2015062, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, National research infrastructure for biological and medical imaging

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

PEŠLOVÁ, Eva, Radek MAREČEK, Daniel Joel SHAW, Tomáš KAŠPÁREK, Martin PAIL a Milan BRÁZDIL. Hippocampal involvement in nonpathological deja vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent. Brain and Behavior. Hoboken: Wiley, 2018, roč. 8, č. 7, s. 1-9. ISSN 2162-3279. Dostupné z: https://dx.doi.org/10.1002/brb3.996.

@article{1486822,
   author = {Pešlová, Eva and Mareček, Radek and Shaw, Daniel Joel and Kašpárek, Tomáš and Pail, Martin and Brázdil, Milan},
   article_location = {Hoboken},
   article_number = {7},
   doi = {http://dx.doi.org/10.1002/brb3.996},
   keywords = {deja vu; hippocampal subfields; hippocampal vulnerability; mesial temporal lobe epilepsy; schizophrenia},
   language = {eng},
   issn = {2162-3279},
   journal = {Brain and Behavior},
   title = {Hippocampal involvement in nonpathological deja vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent},
   volume = {8},
   year = {2018}
}

TY  - JOUR
ID  - 1486822
AU  - Pešlová, Eva - Mareček, Radek - Shaw, Daniel Joel - Kašpárek, Tomáš - Pail, Martin - Brázdil, Milan
PY  - 2018
TI  - Hippocampal involvement in nonpathological deja vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent
JF  - Brain and Behavior
VL  - 8
IS  - 7
SP  - 1-9
EP  - 1-9
PB  - Wiley
SN  - 21623279
KW  - deja vu
KW  - hippocampal subfields
KW  - hippocampal vulnerability
KW  - mesial temporal lobe epilepsy
KW  - schizophrenia
N2  - Introduction: Morphological correlates of nonpathological deja vu (DV) have been identified recently within the human brain. Significantly reduced gray matter volume (GMV) within a set of cortical and subcortical regions reported in subjects experiencing DV seems to mirror the distribution of GMV reduction in mesial temporal lobe epilepsy (MTLE) patients but vary in terms of the hippocampus. Another condition associated with hippocampal GMV reduction and DV alike disturbance in memory processing is schizophrenia (SCH). Here, we tested the hypothesis that hippocampal involvement in nonpathological DV resembles more closely the pattern of GMV decrease observed in MTLE compared with that occurring in SCH. Methods: Using automated segmentation of the MRI data we compared the medians of GMV within 12 specific hippocampal subfields in healthy individuals that do (DV+; N = 87) and do not report deja vu experience (DV-; N = 26), and patients with MTLE (N = 47) and SCH (N = 29). By Pearson correlation, we then evaluated the similarity of MTLE and SCH groups to DV+ group with respect to spatial distribution of GMV deviation from DV- group. Results: Significant GMV decrease was found in MTLE group in most of the subfields. There were just trends in the hippocampal GMV decrease found in DV+ or SCH groups. Concerning the spatial distribution of GMV decrease, we revealed statistically significant correlation for the left hippocampus for SCH vs DV+, Otherwise there was no statistically significant correlation. Conclusions: Our findings reveal structural features of hippocampal involvement in nonpathological DV, MTLE, and SCH. Despite our expectations, the pattern of GMV reduction in the DV+ relative to the DV- group does not resemble the pattern observed in MTLE any more than that observed in SCH. The highly similar patterns of the three clinical groups rather suggest an increased vulnerability of certain hippocampal subfields; namely, Cornu Ammonis (CA)4, CA3, dentate gyrus granular cell layer (GC-DG), hippocampal-amygdaloid transition area (HATA) and subiculum.
ER  -

PEŠLOVÁ, Eva, Radek MAREČEK, Daniel Joel SHAW, Tomáš KAŠPÁREK, Martin PAIL a Milan BRÁZDIL. Hippocampal involvement in nonpathological deja vu: Subfield vulnerability rather than temporal lobe epilepsy equivalent. \textit{Brain and Behavior}. Hoboken: Wiley, 2018, roč.~8, č.~7, s.~1-9. ISSN~2162-3279. Dostupné z: https://dx.doi.org/10.1002/brb3.996.

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