Cardiac sigma receptors - An update

J 2018

Cardiac sigma receptors - An update

STRAČINA, Tibor a Marie NOVÁKOVÁ

Základní údaje

Originální název

Cardiac sigma receptors - An update

Název česky

Srdeční sigma receptory - update

Autoři

STRAČINA, Tibor (703 Slovensko, domácí) a Marie NOVÁKOVÁ (203 Česká republika, garant, domácí)

Vydání

Physiological Research, Praha, Fyziologický ústav AV ČR, 2018, 0862-8408

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.701

Kód RIV

RIV/00216224:14110/18:00105652

Organizační jednotka

Lékařská fakulta

UT WoS

000454598300002

Klíčová slova česky

sigma receptor; srdce; chaperone; stress endoplazmatického retikula

Klíčová slova anglicky

sigma receptor; heart; chaperone; endoplasmic reticulum stress

Štítky

14110515, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 2. 2019 15:26, Soňa Böhmová

Anotace

V originále

More than four decades passed since sigma receptors were first mentioned. Since then, existence of at least two receptor subtypes and their tissue distributions have been proposed. Nowadays, it is clear, that sigma receptors are unique ubiquitous proteins with pluripotent function, which can interact with so many different classes of proteins. As the endoplasmic resident proteins, they work as molecular chaperones – accompany various proteins during their folding, ensure trafficking of the maturated proteins between cellular organelles and regulate their functions. In the heart, sigma receptor type 1 is more dominant. Cardiac sigma 1 receptors regulate response to endoplasmic reticulum stress, modulates calcium signaling in cardiomyocyte and can affect function of voltage-gated ion channels. They contributed in pathophysiology of cardiac hypertrophy, heart failure and many other cardiovascular disorders. Therefore, sigma receptors are potential novel targets for specific treatment of cardiovascular diseases.

Návaznosti

MUNI/A/1157/2017, interní kód MU

Název: Kardiovaskulární systém napříč obory - od molekulární diagnostiky po klinická vyšetření (Akronym: KADIMOKLIN)

Investor: Masarykova univerzita, Kardiovaskulární systém napříč obory - od molekulární diagnostiky po klinická vyšetření, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

STRAČINA, Tibor a Marie NOVÁKOVÁ. Cardiac sigma receptors - An update. Physiological Research. Praha: Fyziologický ústav AV ČR, 2018, roč. 67, Suppl. 4, s. 561-576. ISSN 0862-8408.

@article{1488006,
   author = {Stračina, Tibor and Nováková, Marie},
   article_location = {Praha},
   article_number = {Suppl. 4},
   keywords = {sigma receptor; heart; chaperone; endoplasmic reticulum stress},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Cardiac sigma receptors - An update},
   url = {https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=2ahUKEwjI3PKPm_ffAhUHTBoKHVuvBJYQFjABegQICRAC&url=http%3A%2F%2Fwww.biomed.cas.cz%2Fphysiolres%2Fpdf%2F2018%2F67_S561.pdf&usg=AOvVaw1ZKYQeeUloHDzRF7-6AWyN},
   volume = {67},
   year = {2018}
}

TY  - JOUR
ID  - 1488006
AU  - Stračina, Tibor - Nováková, Marie
PY  - 2018
TI  - Cardiac sigma receptors - An update
JF  - Physiological Research
VL  - 67
IS  - Suppl. 4
SP  - 561-576
EP  - 561-576
PB  - Fyziologický ústav AV ČR
SN  - 08628408
KW  - sigma receptor
KW  - heart
KW  - chaperone
KW  - endoplasmic reticulum stress
UR  - https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=2ahUKEwjI3PKPm_ffAhUHTBoKHVuvBJYQFjABegQICRAC&url=http%3A%2F%2Fwww.biomed.cas.cz%2Fphysiolres%2Fpdf%2F2018%2F67_S561.pdf&usg=AOvVaw1ZKYQeeUloHDzRF7-6AWyN
N2  - More than four decades passed since sigma receptors were first mentioned. Since then, existence of at least two receptor subtypes and their tissue distributions have been proposed. Nowadays, it is clear, that sigma receptors are unique ubiquitous proteins with pluripotent function, which can interact with so many different classes of proteins. As the endoplasmic resident proteins, they work as molecular chaperones – accompany various proteins during their folding, ensure trafficking of the maturated proteins between cellular organelles and regulate their functions. In the heart, sigma receptor type 1 is more dominant. Cardiac sigma 1 receptors regulate response to endoplasmic reticulum stress, modulates calcium signaling in cardiomyocyte and can affect function of voltage-gated ion channels. They contributed in pathophysiology of cardiac hypertrophy, heart failure and many other cardiovascular disorders. Therefore, sigma receptors are potential novel targets for specific treatment of cardiovascular diseases.
ER  -

STRAČINA, Tibor a Marie NOVÁKOVÁ. Cardiac sigma receptors - An update. \textit{Physiological Research}. Praha: Fyziologický ústav AV ČR, 2018, roč.~67, Suppl. 4, s.~561-576. ISSN~0862-8408.

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