Identification of algal growth inhibitors in treated waste
water using effect-directed analysis based on non-target
screening techniques

J 2018

Identification of algal growth inhibitors in treated waste water using effect-directed analysis based on non-target screening techniques

TOUŠOVÁ, Zuzana, Jean FROMENT, Peter OSWALD, Jaroslav SLOBODNÍK, Klára HILSCHEROVÁ et. al.

Základní údaje

Originální název

Identification of algal growth inhibitors in treated waste water using effect-directed analysis based on non-target screening techniques

Autoři

TOUŠOVÁ, Zuzana (203 Česká republika, domácí), Jean FROMENT (276 Německo), Peter OSWALD (703 Slovensko), Jaroslav SLOBODNÍK (703 Slovensko), Klára HILSCHEROVÁ (203 Česká republika, domácí), Kevin V. THOMAS (36 Austrálie), Knut Erik TOLLEFSEN (578 Norsko), Malcolm REID (578 Norsko), Katherine LANGFORD (578 Norsko) a Luděk BLÁHA (203 Česká republika, garant, domácí)

Vydání

Journal of Hazardous Materials, Amsterdam, Elsevier Science BV. 2018, 0304-3894

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.650

Kód RIV

RIV/00216224:14310/18:00105657

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.jhazmat.2018.05.031

UT WoS

000442334400054

Klíčová slova anglicky

Contaminants of emerging concern; Effect directed analysis; Fractionation; Non-target screening; Toxicity drivers

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 1. 2019 15:05, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Growth inhibition of freshwater microalga Pseudokirchneriella subcapitata caused by a waste water treatment plant (WWTP) effluent extract was investigated using an effect directed analysis (EDA) approach. The objective was to identify compounds responsible for the toxicity by combining state-of-the-art sampling, bioanalytical, fractionation and non-target screening techniques. Three fractionation steps of the whole extract were performed and bioactive fractions were analysed with GC (xGC)-MS and LC-HRMS. In total, 383 compounds were tentatively identified, and their toxicity was characterized using US EPA Ecotox database, open scientific literature or modelled by ECOSAR. Among the top-ranking drivers of toxicity were pesticides and their transformation products, pharmaceuticals (barbiturate derivatives and macrolide antibiotics e.g. azithromycin), industrial compounds or caffeine and its metabolites. Several of the top-ranking pesticides are no longer registered for use in plant protection products or biocides in the Czech Republic (e.g. prometryn, atrazine, acetochlor, resmethrin) and some are approved only for use in biocides (e.g. terbutryn, carbendazim, phenothrin), which indicates that their non-agricultural input into aquatic environment via WWT'Ps should be carefully considered. The study demonstrated a functional strategy of combining biotesting, fractionation and non-target screening techniques in the EDA study focused on the identification of algal growth inhibitors in WWTP effluent.

Návaznosti

CZ.02.1.01/0.0/0.0/16_013/0001761, interní kód MU

Název: RECETOX RI - OP VVV (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI - OP VVV, PO 1 Posilování kapacit pro kvalitní výzkum

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

603437, interní kód MU

Název: SOLUTIONS - Solutions for present and future emerging pollutants in land and water resources management (Akronym: SOLUTIONS)

Investor: Evropská unie, SOLUTIONS - Solutions for present and future emerging pollutants in land and water resources management, Spolupráce

Citovat

TOUŠOVÁ, Zuzana, Jean FROMENT, Peter OSWALD, Jaroslav SLOBODNÍK, Klára HILSCHEROVÁ, Kevin V. THOMAS, Knut Erik TOLLEFSEN, Malcolm REID, Katherine LANGFORD a Luděk BLÁHA. Identification of algal growth inhibitors in treated waste water using effect-directed analysis based on non-target screening techniques. Journal of Hazardous Materials. Amsterdam: Elsevier Science BV., 2018, roč. 358, September, s. 494-502. ISSN 0304-3894. Dostupné z: https://dx.doi.org/10.1016/j.jhazmat.2018.05.031.

@article{1488073,
   author = {Toušová, Zuzana and Froment, Jean and Oswald, Peter and Slobodník, Jaroslav and Hilscherová, Klára and Thomas, Kevin V. and Tollefsen, Knut Erik and Reid, Malcolm and Langford, Katherine and Bláha, Luděk},
   article_location = {Amsterdam},
   article_number = {September},
   doi = {http://dx.doi.org/10.1016/j.jhazmat.2018.05.031},
   keywords = {Contaminants of emerging concern; Effect directed analysis; Fractionation; Non-target screening; Toxicity drivers},
   language = {eng},
   issn = {0304-3894},
   journal = {Journal of Hazardous Materials},
   title = {Identification of algal growth inhibitors in treated waste water using effect-directed analysis based on non-target screening techniques},
   url = {https://www.sciencedirect.com/science/article/pii/S0304389418303807?via%3Dihub},
   volume = {358},
   year = {2018}
}

TY  - JOUR
ID  - 1488073
AU  - Toušová, Zuzana - Froment, Jean - Oswald, Peter - Slobodník, Jaroslav - Hilscherová, Klára - Thomas, Kevin V. - Tollefsen, Knut Erik - Reid, Malcolm - Langford, Katherine - Bláha, Luděk
PY  - 2018
TI  - Identification of algal growth inhibitors in treated waste water using effect-directed analysis based on non-target screening techniques
JF  - Journal of Hazardous Materials
VL  - 358
IS  - September
SP  - 494-502
EP  - 494-502
PB  - Elsevier Science BV.
SN  - 03043894
KW  - Contaminants of emerging concern
KW  - Effect directed analysis
KW  - Fractionation
KW  - Non-target screening
KW  - Toxicity drivers
UR  - https://www.sciencedirect.com/science/article/pii/S0304389418303807?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0304389418303807?via%3Dihub
N2  - Growth inhibition of freshwater microalga Pseudokirchneriella subcapitata caused by a waste water treatment plant (WWTP) effluent extract was investigated using an effect directed analysis (EDA) approach. The objective was to identify compounds responsible for the toxicity by combining state-of-the-art sampling, bioanalytical, fractionation and non-target screening techniques. Three fractionation steps of the whole extract were performed and bioactive fractions were analysed with GC (xGC)-MS and LC-HRMS. In total, 383 compounds were tentatively identified, and their toxicity was characterized using US EPA Ecotox database, open scientific literature or modelled by ECOSAR. Among the top-ranking drivers of toxicity were pesticides and their transformation products, pharmaceuticals (barbiturate derivatives and macrolide antibiotics e.g. azithromycin), industrial compounds or caffeine and its metabolites. Several of the top-ranking pesticides are no longer registered for use in plant protection products or biocides in the Czech Republic (e.g. prometryn, atrazine, acetochlor, resmethrin) and some are approved only for use in biocides (e.g. terbutryn, carbendazim, phenothrin), which indicates that their non-agricultural input into aquatic environment via WWT'Ps should be carefully considered. The study demonstrated a functional strategy of combining biotesting, fractionation and non-target screening techniques in the EDA study focused on the identification of algal growth inhibitors in WWTP effluent.
ER  -

TOUŠOVÁ, Zuzana, Jean FROMENT, Peter OSWALD, Jaroslav SLOBODNÍK, Klára HILSCHEROVÁ, Kevin V. THOMAS, Knut Erik TOLLEFSEN, Malcolm REID, Katherine LANGFORD a Luděk BLÁHA. Identification of algal growth inhibitors in treated waste water using effect-directed analysis based on non-target screening techniques. \textit{Journal of Hazardous Materials}. Amsterdam: Elsevier Science BV., 2018, roč.~358, September, s.~494-502. ISSN~0304-3894. Dostupné z: https://dx.doi.org/10.1016/j.jhazmat.2018.05.031.

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