Screening and risk management solutions for steroidal estrogens
in surface and wastewater

J 2018

Screening and risk management solutions for steroidal estrogens in surface and wastewater

KASE, Robert, Barbora JAVŮRKOVÁ, Eszter SIMON, Kees SWART, Sebastian BUCHINGER et. al.

Základní údaje

Originální název

Screening and risk management solutions for steroidal estrogens in surface and wastewater

Autoři

KASE, Robert (756 Švýcarsko), Barbora JAVŮRKOVÁ (203 Česká republika, domácí), Eszter SIMON (756 Švýcarsko), Kees SWART (528 Nizozemské království), Sebastian BUCHINGER (276 Německo), Sarah KONEMANN (276 Německo), Beate I. ESCHER (276 Německo), Mario CARERE (380 Itálie), Valeria DULIO (250 Francie), Selim AIT-AISSA (250 Francie), Henner HOLLERT (276 Německo), Sara VALSECCHI (380 Itálie), Stefano POLESELLO (380 Itálie), Peter BEHNISCH (528 Nizozemské království), Carolina DI PAOLO (276 Německo), Daniel OLBRICH (756 Švýcarsko), Eliška SYCHROVÁ (203 Česká republika, domácí), Michael GUNDLACH (276 Německo), Rita SCHLICHTING (276 Německo), Lomig LEBORGNE (250 Francie), Manfred CLARA (40 Rakousko), Christoph SCHEFFKNECHT (40 Rakousko), Yves MARNEFFE (56 Belgie), Carole CHALON (56 Belgie), Petr TUSIL (203 Česká republika), Premysl SOLDAN (203 Česká republika), Brigitte VON DANWITZ (276 Německo), Julia SCHWAIGER (276 Německo), Antonio MORAN PALAO (724 Španělsko), Francesca BERSANI (380 Itálie), Olivier PERCEVAL (250 Francie), Cornelia KIENLE (756 Švýcarsko), Etienne VERMEIRSSEN (756 Švýcarsko), Klára HILSCHEROVÁ (203 Česká republika, garant, domácí), Georg REIFFERSCHEID (276 Německo) a Inge WERNER (756 Švýcarsko)

Vydání

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, OXFORD, ELSEVIER SCI LTD, 2018, 0165-9936

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10406 Analytical chemistry

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.428

Kód RIV

RIV/00216224:14310/18:00105707

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.trac.2018.02.013

UT WoS

000435751100026

Klíčová slova anglicky

Effect-based methods; Science-policy interface; Oestrogen screening; Endocrine disruption; Surface and wastewater assessment; Risk-based trigger values; EU watch-list; Water framework directive; Chemical monitoring of Emerging pollutants

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 1. 2019 20:47, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Background: The European Commission Implementing Decision EU 2015/495 included three steroidal estrogens, namely 17 alpha-ethinyl estradiol, 170-estradiol, and estrone, in the so-called "watch list" of the EU Water Framework Directive (WFD). The monitoring of these compounds is difficult because the detection limits of the majority of the available analytical methods cannot achieve the very low target concentrations required to meet proposed environmental quality criteria. In 2014, a combined Science-Policy Interface/Chemical Monitoring of Emerging Pollutants project was launched to meet this monitoring challenge. The project involved 24 research organizations and environmental agencies from 12 different countries. Methods: Sixteen surface water (SW) and 17 wastewater (WW) samples were collected across Europe and analysed using five in vitro effect-based and three chemical analytical methods. A general description of the project and data evaluation is provided by Konemann and colleagues in the companion publication 2018. In our study, we compared bioanalytical and chemical analytical results with regard to their application for aquatic status assessment. Therefore we considered the potential to predict population-relevant risks for aquatic organisms and the specificity and sensitivity of the various methods used in both approaches. Finally, we tested and discussed the applicability and relevance of previously suggested effect-based trigger values (EBT). Results and discussion: Results of the risk assessment based on chemical analytical data correlated highly with estrogenic activities (expressed as 170-estradiol equivalents (EEQ) determined using effect-based methods), demonstrating the ability of the bioassays to predict the mixture risk caused by steroidal estrogens. For about 15% of SW and 40% of WW samples detection limits of chemical-analytical methods were too high to allow a status assessment, while detection limits of all effect-based methods were below proposed EBT. This demonstrates that effect-based methods are suitable for status assessment of surface waters. The in vitro effect-based methods were quite specific for steroidal estrogens and highly sensitive, meaning they have a low probability to detect false positive or negative results. After testing of three alternative EBT proposals, we concluded to use preliminary 400 mu g/L, EEQ as screening EBT corresponding to the AA-EQS of E2. Further test specific refinements in the application of this value are not excluded. Conclusions: We conclude that water quality assessment can progress from a purely analytical approach to effect-based monitoring, from single substance to known and unknown mixture assessment and from in vitro screening to population-relevant risk assessment. Despite a few limitations, effect-based in vitro methods are recommendable for monitoring steroidal estrogens under the WFD because they, a) are able to sensitively quantify the activity of steroidal estrogens in all surface and wastewater samples, b) are able to detect the combined effect of estrogen mixtures including unknown chemicals with estrogen receptor activating properties, c) allow an ecotoxicological status assessment using EBT to calculate risk quotients. This approach is similar to the risk ratio used in regulatory environmental risk assessments, but allows for an integrated mixture assessment. Outlook: The results of this study support the introduction of a holistic approach for the regulation of chemicals in the aquatic environment under the EU WFD, as proposed recently by EU Water Directors. An ecotoxicological status assessment for one of the most relevant modes of action of endocrine disruption will allow authorities responsible for water quality assessment to focus available monitoring resources and to improve the ecological status of EU waterbodies. (C) 2018 Swiss Centre for Applied Ecotoxicology Eawag/EPFL. Published by Elsevier B.V.

Návaznosti

603437, interní kód MU

Název: SOLUTIONS - Solutions for present and future emerging pollutants in land and water resources management (Akronym: SOLUTIONS)

Investor: Evropská unie, SOLUTIONS - Solutions for present and future emerging pollutants in land and water resources management, Spolupráce

Citovat

KASE, Robert, Barbora JAVŮRKOVÁ, Eszter SIMON, Kees SWART, Sebastian BUCHINGER, Sarah KONEMANN, Beate I. ESCHER, Mario CARERE, Valeria DULIO, Selim AIT-AISSA, Henner HOLLERT, Sara VALSECCHI, Stefano POLESELLO, Peter BEHNISCH, Carolina DI PAOLO, Daniel OLBRICH, Eliška SYCHROVÁ, Michael GUNDLACH, Rita SCHLICHTING, Lomig LEBORGNE, Manfred CLARA, Christoph SCHEFFKNECHT, Yves MARNEFFE, Carole CHALON, Petr TUSIL, Premysl SOLDAN, Brigitte VON DANWITZ, Julia SCHWAIGER, Antonio MORAN PALAO, Francesca BERSANI, Olivier PERCEVAL, Cornelia KIENLE, Etienne VERMEIRSSEN, Klára HILSCHEROVÁ, Georg REIFFERSCHEID a Inge WERNER. Screening and risk management solutions for steroidal estrogens in surface and wastewater. TRAC-TRENDS IN ANALYTICAL CHEMISTRY. OXFORD: ELSEVIER SCI LTD, 2018, roč. 102, May, s. 343-358. ISSN 0165-9936. Dostupné z: https://dx.doi.org/10.1016/j.trac.2018.02.013.

@article{1488439,
   author = {Kase, Robert and Javůrková, Barbora and Simon, Eszter and Swart, Kees and Buchinger, Sebastian and Konemann, Sarah and Escher, Beate I. and Carere, Mario and Dulio, Valeria and AitandAissa, Selim and Hollert, Henner and Valsecchi, Sara and Polesello, Stefano and Behnisch, Peter and di Paolo, Carolina and Olbrich, Daniel and Sychrová, Eliška and Gundlach, Michael and Schlichting, Rita and Leborgne, Lomig and Clara, Manfred and Scheffknecht, Christoph and Marneffe, Yves and Chalon, Carole and Tusil, Petr and Soldan, Premysl and von Danwitz, Brigitte and Schwaiger, Julia and Moran Palao, Antonio and Bersani, Francesca and Perceval, Olivier and Kienle, Cornelia and Vermeirssen, Etienne and Hilscherová, Klára and Reifferscheid, Georg and Werner, Inge},
   article_location = {OXFORD},
   article_number = {May},
   doi = {http://dx.doi.org/10.1016/j.trac.2018.02.013},
   keywords = {Effect-based methods; Science-policy interface; Oestrogen screening; Endocrine disruption; Surface and wastewater assessment; Risk-based trigger values; EU watch-list; Water framework directive; Chemical monitoring of Emerging pollutants},
   language = {eng},
   issn = {0165-9936},
   journal = {TRAC-TRENDS IN ANALYTICAL CHEMISTRY},
   title = {Screening and risk management solutions for steroidal estrogens in surface and wastewater},
   url = {https://www.sciencedirect.com/science/article/pii/S0165993617304375?via%3Dihub},
   volume = {102},
   year = {2018}
}

TY  - JOUR
ID  - 1488439
AU  - Kase, Robert - Javůrková, Barbora - Simon, Eszter - Swart, Kees - Buchinger, Sebastian - Konemann, Sarah - Escher, Beate I. - Carere, Mario - Dulio, Valeria - Ait-Aissa, Selim - Hollert, Henner - Valsecchi, Sara - Polesello, Stefano - Behnisch, Peter - di Paolo, Carolina - Olbrich, Daniel - Sychrová, Eliška - Gundlach, Michael - Schlichting, Rita - Leborgne, Lomig - Clara, Manfred - Scheffknecht, Christoph - Marneffe, Yves - Chalon, Carole - Tusil, Petr - Soldan, Premysl - von Danwitz, Brigitte - Schwaiger, Julia - Moran Palao, Antonio - Bersani, Francesca - Perceval, Olivier - Kienle, Cornelia - Vermeirssen, Etienne - Hilscherová, Klára - Reifferscheid, Georg - Werner, Inge
PY  - 2018
TI  - Screening and risk management solutions for steroidal estrogens in surface and wastewater
JF  - TRAC-TRENDS IN ANALYTICAL CHEMISTRY
VL  - 102
IS  - May
SP  - 343-358
EP  - 343-358
PB  - ELSEVIER SCI LTD
SN  - 01659936
KW  - Effect-based methods
KW  - Science-policy interface
KW  - Oestrogen screening
KW  - Endocrine disruption
KW  - Surface and wastewater assessment
KW  - Risk-based trigger values
KW  - EU watch-list
KW  - Water framework directive
KW  - Chemical monitoring of Emerging pollutants
UR  - https://www.sciencedirect.com/science/article/pii/S0165993617304375?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0165993617304375?via%3Dihub
N2  - Background: The European Commission Implementing Decision EU 2015/495 included three steroidal estrogens, namely 17 alpha-ethinyl estradiol, 170-estradiol, and estrone, in the so-called "watch list" of the EU Water Framework Directive (WFD). The monitoring of these compounds is difficult because the detection limits of the majority of the available analytical methods cannot achieve the very low target concentrations required to meet proposed environmental quality criteria. In 2014, a combined Science-Policy Interface/Chemical Monitoring of Emerging Pollutants project was launched to meet this monitoring challenge. The project involved 24 research organizations and environmental agencies from 12 different countries. Methods: Sixteen surface water (SW) and 17 wastewater (WW) samples were collected across Europe and analysed using five in vitro effect-based and three chemical analytical methods. A general description of the project and data evaluation is provided by Konemann and colleagues in the companion publication 2018. In our study, we compared bioanalytical and chemical analytical results with regard to their application for aquatic status assessment. Therefore we considered the potential to predict population-relevant risks for aquatic organisms and the specificity and sensitivity of the various methods used in both approaches. Finally, we tested and discussed the applicability and relevance of previously suggested effect-based trigger values (EBT). Results and discussion: Results of the risk assessment based on chemical analytical data correlated highly with estrogenic activities (expressed as 170-estradiol equivalents (EEQ) determined using effect-based methods), demonstrating the ability of the bioassays to predict the mixture risk caused by steroidal estrogens. For about 15% of SW and 40% of WW samples detection limits of chemical-analytical methods were too high to allow a status assessment, while detection limits of all effect-based methods were below proposed EBT. This demonstrates that effect-based methods are suitable for status assessment of surface waters. The in vitro effect-based methods were quite specific for steroidal estrogens and highly sensitive, meaning they have a low probability to detect false positive or negative results. After testing of three alternative EBT proposals, we concluded to use preliminary 400 mu g/L, EEQ as screening EBT corresponding to the AA-EQS of E2. Further test specific refinements in the application of this value are not excluded. Conclusions: We conclude that water quality assessment can progress from a purely analytical approach to effect-based monitoring, from single substance to known and unknown mixture assessment and from in vitro screening to population-relevant risk assessment. Despite a few limitations, effect-based in vitro methods are recommendable for monitoring steroidal estrogens under the WFD because they, a) are able to sensitively quantify the activity of steroidal estrogens in all surface and wastewater samples, b) are able to detect the combined effect of estrogen mixtures including unknown chemicals with estrogen receptor activating properties, c) allow an ecotoxicological status assessment using EBT to calculate risk quotients. This approach is similar to the risk ratio used in regulatory environmental risk assessments, but allows for an integrated mixture assessment. Outlook: The results of this study support the introduction of a holistic approach for the regulation of chemicals in the aquatic environment under the EU WFD, as proposed recently by EU Water Directors. An ecotoxicological status assessment for one of the most relevant modes of action of endocrine disruption will allow authorities responsible for water quality assessment to focus available monitoring resources and to improve the ecological status of EU waterbodies. (C) 2018 Swiss Centre for Applied Ecotoxicology Eawag/EPFL. Published by Elsevier B.V.
ER  -

KASE, Robert, Barbora JAVŮRKOVÁ, Eszter SIMON, Kees SWART, Sebastian BUCHINGER, Sarah KONEMANN, Beate I. ESCHER, Mario CARERE, Valeria DULIO, Selim AIT-AISSA, Henner HOLLERT, Sara VALSECCHI, Stefano POLESELLO, Peter BEHNISCH, Carolina DI PAOLO, Daniel OLBRICH, Eliška SYCHROVÁ, Michael GUNDLACH, Rita SCHLICHTING, Lomig LEBORGNE, Manfred CLARA, Christoph SCHEFFKNECHT, Yves MARNEFFE, Carole CHALON, Petr TUSIL, Premysl SOLDAN, Brigitte VON DANWITZ, Julia SCHWAIGER, Antonio MORAN PALAO, Francesca BERSANI, Olivier PERCEVAL, Cornelia KIENLE, Etienne VERMEIRSSEN, Klára HILSCHEROVÁ, Georg REIFFERSCHEID a Inge WERNER. Screening and risk management solutions for steroidal estrogens in surface and wastewater. \textit{TRAC-TRENDS IN ANALYTICAL CHEMISTRY}. OXFORD: ELSEVIER SCI LTD, 2018, roč.~102, May, s.~343-358. ISSN~0165-9936. Dostupné z: https://dx.doi.org/10.1016/j.trac.2018.02.013.

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