J 2018

Theory of Mind Skills Are Related to Resting-State Frontolimbic Connectivity in Schizophrenia

HOLŠTAJN ZEMÁNKOVÁ, Petra, Jan LOŠÁK, Kristína CZEKÓOVÁ, Ovidiu LUNGU, Martin JÁNI et. al.

Základní údaje

Originální název

Theory of Mind Skills Are Related to Resting-State Frontolimbic Connectivity in Schizophrenia

Autoři

HOLŠTAJN ZEMÁNKOVÁ, Petra (203 Česká republika, garant, domácí), Jan LOŠÁK (203 Česká republika, domácí), Kristína CZEKÓOVÁ (703 Slovensko, domácí), Ovidiu LUNGU (124 Kanada), Martin JÁNI (703 Slovensko, domácí), Tomáš KAŠPÁREK (203 Česká republika, domácí) a Martin BAREŠ (203 Česká republika, domácí)

Vydání

BRAIN CONNECTIVITY, NEW ROCHELLE, MARY ANN LIEBERT, INC, 2018, 2158-0014

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/18:00105775

Organizační jednotka

Lékařská fakulta

DOI

UT WoS

000452155400005

Klíčová slova anglicky

fMRI; resting-state functional connectivity; schizophrenia; seed voxel analysis; theory of mind

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 18. 3. 2019 14:46, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Patients with schizophrenia (SCH) often demonstrate impairment in social-cognitive functions as well as disturbances in large-scale network connectivity. The ventromedial prefrontal cortex (vmPFC) is a core region of the default mode network, with projections to limbic structures. It plays an important role in social and emotional decision-making. We investigated whether resting-state functional connectivity (FC) relates to the cognitive and affective domains of theory of mind (ToM). Twenty-three SCH patients and 19 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scanning. vmPFC seed connectivity was correlated with behavioral measures assessing ToM domains. SCH performed less well than HCs in both ToM task domains. An analysis of the resting-state FC revealed that SCH had reduced connectivity from the vmPFC to the subcallosal cortex, right amygdala, and right hippocampus as a function of behavioral scores in both ToM domains. Within-group analyses indicated that in HCs, the performance in ToM was positively associated with frontoamygdalar resting-state connectivity, whereas in SCH, the performance in ToM was negatively associated with the frontosubcallosal connectivity. Differences in the pattern of the resting-state frontolimbic connectivity and its associations with performance in ToM tasks between the two study groups might represent a different setup for processing social information in patients with SCH.