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@article{1489407,
author = {Klánová, Barbara and Zlámal, Filip and Pohořalá, Aneta and Slabý, Ondřej and Pikhart, Hynek and Dobrovolná, Julie},
article_location = {ABINGDON},
article_number = {2},
doi = {http://dx.doi.org/10.1080/07315724.2017.1360807},
keywords = {Dietary composition; food records; genetic polymorphisms; glutathione S-transferase},
language = {eng},
issn = {0731-5724},
journal = {JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION},
title = {Association of Glutathione S-Transferase Polymorphisms with Dietary Composition but Not Anthropometry in Obese as Well as Nonobese Individuals},
url = {https://www.tandfonline.com/doi/full/10.1080/07315724.2017.1360807},
volume = {37},
year = {2018}
}
TY - JOUR
ID - 1489407
AU - Klánová, Barbara - Zlámal, Filip - Pohořalá, Aneta - Slabý, Ondřej - Pikhart, Hynek - Dobrovolná, Julie
PY - 2018
TI - Association of Glutathione S-Transferase Polymorphisms with Dietary Composition but Not Anthropometry in Obese as Well as Nonobese Individuals
JF - JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
VL - 37
IS - 2
SP - 87-92
EP - 87-92
PB - ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
SN - 07315724
KW - Dietary composition
KW - food records
KW - genetic polymorphisms
KW - glutathione S-transferase
UR - https://www.tandfonline.com/doi/full/10.1080/07315724.2017.1360807
L2 - https://www.tandfonline.com/doi/full/10.1080/07315724.2017.1360807
N2 - Objectives: Glutathione S-transferases (GSTs) are detoxifying enzymes for a number of substrates, including some food compounds. Selected GST polymorphisms have been proven to significantly affect enzymatic activity; however, it is unclear whether this altered metabolism influences dietary composition. The objective of this study was to locate the correlation between GST polymorphisms and selected nutritional parameters, namely, fiber and vitamin C intake. Methods: This study was conducted on a cohort of 472 individuals (mean age 45.26 years; mean body mass index [BMI] 32.36) from the South Moravian region of the Czech Republic. Basic anthropometrical parameters were measured and no association was found for the selected polymorphisms. Polymorphisms in GSTA1, GSTM1, and GSTT1 were genotyped using a polymerase chain reaction (PCR)-based methodology. Food intake was monitored using a self-administered 7-day questionnaire that was subsequently analyzed with a special focus on vitamin C intake, fiber intake, and total energy intake. Results: For GSTA1 and GSTM1 polymorphisms, an association was observed with fiber intake. Though no association was found with vitamin C intake, mean vitamin C intake was found to be higher than recommended daily values. No association was found with either daily energy intake or anthropometric parameters. Conclusion: Based on our results, GST polymorphisms seem to affect dietary composition; however, they have no effect on total energy intake or any association with obesity.
ER -
KLÁNOVÁ, Barbara, Filip ZLÁMAL, Aneta POHOŘALÁ, Ondřej SLABÝ, Hynek PIKHART and Julie DOBROVOLNÁ. Association of Glutathione S-Transferase Polymorphisms with Dietary Composition but Not Anthropometry in Obese as Well as Nonobese Individuals. \textit{JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION}. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR \&{}amp; FRANCIS LTD, vol.~37, No~2, p.~87-92. ISSN~0731-5724. doi:10.1080/07315724.2017.1360807. 2018.
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