Association of Glutathione S-Transferase Polymorphisms with
Dietary Composition but Not Anthropometry in Obese as Well as
Nonobese Individuals

J 2018

Association of Glutathione S-Transferase Polymorphisms with Dietary Composition but Not Anthropometry in Obese as Well as Nonobese Individuals

KLÁNOVÁ, Barbara, Filip ZLÁMAL, Aneta POHOŘALÁ, Ondřej SLABÝ, Hynek PIKHART et. al.

Základní údaje

Originální název

Association of Glutathione S-Transferase Polymorphisms with Dietary Composition but Not Anthropometry in Obese as Well as Nonobese Individuals

Autoři

KLÁNOVÁ, Barbara (203 Česká republika), Filip ZLÁMAL (203 Česká republika, domácí), Aneta POHOŘALÁ (203 Česká republika, domácí), Ondřej SLABÝ (203 Česká republika, domácí), Hynek PIKHART (203 Česká republika) a Julie DOBROVOLNÁ (203 Česká republika, garant, domácí)

Vydání

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, ABINGDON, ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2018, 0731-5724

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30308 Nutrition, Dietetics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.080

Kód RIV

RIV/00216224:14310/18:00105813

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1080/07315724.2017.1360807

UT WoS

000428592600001

Klíčová slova anglicky

Dietary composition; food records; genetic polymorphisms; glutathione S-transferase

Štítky

14110525, 14110811, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 5. 2019 16:26, Mgr. Tereza Miškechová

Anotace

V originále

Objectives: Glutathione S-transferases (GSTs) are detoxifying enzymes for a number of substrates, including some food compounds. Selected GST polymorphisms have been proven to significantly affect enzymatic activity; however, it is unclear whether this altered metabolism influences dietary composition. The objective of this study was to locate the correlation between GST polymorphisms and selected nutritional parameters, namely, fiber and vitamin C intake. Methods: This study was conducted on a cohort of 472 individuals (mean age 45.26 years; mean body mass index [BMI] 32.36) from the South Moravian region of the Czech Republic. Basic anthropometrical parameters were measured and no association was found for the selected polymorphisms. Polymorphisms in GSTA1, GSTM1, and GSTT1 were genotyped using a polymerase chain reaction (PCR)-based methodology. Food intake was monitored using a self-administered 7-day questionnaire that was subsequently analyzed with a special focus on vitamin C intake, fiber intake, and total energy intake. Results: For GSTA1 and GSTM1 polymorphisms, an association was observed with fiber intake. Though no association was found with vitamin C intake, mean vitamin C intake was found to be higher than recommended daily values. No association was found with either daily energy intake or anthropometric parameters. Conclusion: Based on our results, GST polymorphisms seem to affect dietary composition; however, they have no effect on total energy intake or any association with obesity.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

KLÁNOVÁ, Barbara, Filip ZLÁMAL, Aneta POHOŘALÁ, Ondřej SLABÝ, Hynek PIKHART a Julie DOBROVOLNÁ. Association of Glutathione S-Transferase Polymorphisms with Dietary Composition but Not Anthropometry in Obese as Well as Nonobese Individuals. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2018, roč. 37, č. 2, s. 87-92. ISSN 0731-5724. Dostupné z: https://dx.doi.org/10.1080/07315724.2017.1360807.

@article{1489407,
   author = {Klánová, Barbara and Zlámal, Filip and Pohořalá, Aneta and Slabý, Ondřej and Pikhart, Hynek and Dobrovolná, Julie},
   article_location = {ABINGDON},
   article_number = {2},
   doi = {http://dx.doi.org/10.1080/07315724.2017.1360807},
   keywords = {Dietary composition; food records; genetic polymorphisms; glutathione S-transferase},
   language = {eng},
   issn = {0731-5724},
   journal = {JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION},
   title = {Association of Glutathione S-Transferase Polymorphisms with Dietary Composition but Not Anthropometry in Obese as Well as Nonobese Individuals},
   url = {https://www.tandfonline.com/doi/full/10.1080/07315724.2017.1360807},
   volume = {37},
   year = {2018}
}

TY  - JOUR
ID  - 1489407
AU  - Klánová, Barbara - Zlámal, Filip - Pohořalá, Aneta - Slabý, Ondřej - Pikhart, Hynek - Dobrovolná, Julie
PY  - 2018
TI  - Association of Glutathione S-Transferase Polymorphisms with Dietary Composition but Not Anthropometry in Obese as Well as Nonobese Individuals
JF  - JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
VL  - 37
IS  - 2
SP  - 87-92
EP  - 87-92
PB  - ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
SN  - 07315724
KW  - Dietary composition
KW  - food records
KW  - genetic polymorphisms
KW  - glutathione S-transferase
UR  - https://www.tandfonline.com/doi/full/10.1080/07315724.2017.1360807
L2  - https://www.tandfonline.com/doi/full/10.1080/07315724.2017.1360807
N2  - Objectives: Glutathione S-transferases (GSTs) are detoxifying enzymes for a number of substrates, including some food compounds. Selected GST polymorphisms have been proven to significantly affect enzymatic activity; however, it is unclear whether this altered metabolism influences dietary composition. The objective of this study was to locate the correlation between GST polymorphisms and selected nutritional parameters, namely, fiber and vitamin C intake. Methods: This study was conducted on a cohort of 472 individuals (mean age 45.26 years; mean body mass index [BMI] 32.36) from the South Moravian region of the Czech Republic. Basic anthropometrical parameters were measured and no association was found for the selected polymorphisms. Polymorphisms in GSTA1, GSTM1, and GSTT1 were genotyped using a polymerase chain reaction (PCR)-based methodology. Food intake was monitored using a self-administered 7-day questionnaire that was subsequently analyzed with a special focus on vitamin C intake, fiber intake, and total energy intake. Results: For GSTA1 and GSTM1 polymorphisms, an association was observed with fiber intake. Though no association was found with vitamin C intake, mean vitamin C intake was found to be higher than recommended daily values. No association was found with either daily energy intake or anthropometric parameters. Conclusion: Based on our results, GST polymorphisms seem to affect dietary composition; however, they have no effect on total energy intake or any association with obesity.
ER  -

KLÁNOVÁ, Barbara, Filip ZLÁMAL, Aneta POHOŘALÁ, Ondřej SLABÝ, Hynek PIKHART a Julie DOBROVOLNÁ. Association of Glutathione S-Transferase Polymorphisms with Dietary Composition but Not Anthropometry in Obese as Well as Nonobese Individuals. \textit{JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION}. ABINGDON: ROUTLEDGE JOURNALS, TAYLOR \&{}amp; FRANCIS LTD, 2018, roč.~37, č.~2, s.~87-92. ISSN~0731-5724. Dostupné z: https://dx.doi.org/10.1080/07315724.2017.1360807.

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