Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain
tumors

J 2018

Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors

KOPKOVÁ, Alena, Jiří ŠÁNA, Pavel FADRUS a Ondřej SLABÝ

Základní údaje

Originální název

Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors

Autoři

KOPKOVÁ, Alena (203 Česká republika, domácí), Jiří ŠÁNA (203 Česká republika, domácí), Pavel FADRUS (203 Česká republika, domácí) a Ondřej SLABÝ (203 Česká republika, garant, domácí)

Vydání

Clinical Chemistry and Laboratory medicine, BERLIN, WALTER DE GRUYTER & CO, 2018, 1434-6621

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

20602 Medical laboratory technology ;

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.638

Kód RIV

RIV/00216224:14740/18:00105814

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1515/cclm-2017-0958

UT WoS

000431126000012

Klíčová slova anglicky

biomarker; brain cancer; cerebrospinal fluid (CSF); diagnosis; microRNA; prognosis

Štítky

14110224, 14110811, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 3. 2019 13:04, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Cerebrospinal fluid (CSF) is a body fluid that has many important functions and is in direct contact with the extracellular environment of the central nervous system (CNS). CSF serves as both the communication channel allowing the distribution of various substances among the CNS cells and the storage facility for the waste products these cells release. For these reasons, CSF is a potential source of diagnostic biomarkers of many CNS diseases, including brain tumors. Recent studies have revealed that CSF also contains circulating microRNAs (miRNAs), short non-coding RNAs that have been described as biomarkers in many cancers. However, CSF miRNAs are difficult to detect, which is why researchers face major challenges, including technological difficulties in its detection and its lack of standardization. Therefore, this review aims (i) to highlight the potential of CSF miRNAs as diagnostic, prognostic and predictive biomarkers in brain tumors, and (ii) to summarize technological approaches for detection of CSF miRNAs.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NV15-33158A, projekt VaV

Název: Nová úroveň molekulární taxonomie glioblastomu založená na expresních profilech dlouhých nekódujících RNA: implikace pro diagnostiku a terapii

NV15-34553A, projekt VaV

Název: Využití mikroRNA v mozkomíšním moku pro diagnostiku mozkových nádorů

Citovat

KOPKOVÁ, Alena, Jiří ŠÁNA, Pavel FADRUS a Ondřej SLABÝ. Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors. Clinical Chemistry and Laboratory medicine. BERLIN: WALTER DE GRUYTER & CO, 2018, roč. 56, č. 6, s. 869-879. ISSN 1434-6621. Dostupné z: https://dx.doi.org/10.1515/cclm-2017-0958.

@article{1489412,
   author = {Kopková, Alena and Šána, Jiří and Fadrus, Pavel and Slabý, Ondřej},
   article_location = {BERLIN},
   article_number = {6},
   doi = {http://dx.doi.org/10.1515/cclm-2017-0958},
   keywords = {biomarker; brain cancer; cerebrospinal fluid (CSF); diagnosis; microRNA; prognosis},
   language = {eng},
   issn = {1434-6621},
   journal = {Clinical Chemistry and Laboratory medicine},
   title = {Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors},
   volume = {56},
   year = {2018}
}

TY  - JOUR
ID  - 1489412
AU  - Kopková, Alena - Šána, Jiří - Fadrus, Pavel - Slabý, Ondřej
PY  - 2018
TI  - Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors
JF  - Clinical Chemistry and Laboratory medicine
VL  - 56
IS  - 6
SP  - 869-879
EP  - 869-879
PB  - WALTER DE GRUYTER & CO
SN  - 14346621
KW  - biomarker
KW  - brain cancer
KW  - cerebrospinal fluid (CSF)
KW  - diagnosis
KW  - microRNA
KW  - prognosis
N2  - Cerebrospinal fluid (CSF) is a body fluid that has many important functions and is in direct contact with the extracellular environment of the central nervous system (CNS). CSF serves as both the communication channel allowing the distribution of various substances among the CNS cells and the storage facility for the waste products these cells release. For these reasons, CSF is a potential source of diagnostic biomarkers of many CNS diseases, including brain tumors. Recent studies have revealed that CSF also contains circulating microRNAs (miRNAs), short non-coding RNAs that have been described as biomarkers in many cancers. However, CSF miRNAs are difficult to detect, which is why researchers face major challenges, including technological difficulties in its detection and its lack of standardization. Therefore, this review aims (i) to highlight the potential of CSF miRNAs as diagnostic, prognostic and predictive biomarkers in brain tumors, and (ii) to summarize technological approaches for detection of CSF miRNAs.
ER  -

KOPKOVÁ, Alena, Jiří ŠÁNA, Pavel FADRUS a Ondřej SLABÝ. Cerebrospinal fluid microRNAs as diagnostic biomarkers in brain tumors. \textit{Clinical Chemistry and Laboratory medicine}. BERLIN: WALTER DE GRUYTER \&{}amp; CO, 2018, roč.~56, č.~6, s.~869-879. ISSN~1434-6621. Dostupné z: https://dx.doi.org/10.1515/cclm-2017-0958.

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