| CAPOOR, Manu, Filip RŮŽIČKA, Gurpreet SANDHU, Jess ROLLASON, Konstantinos MAVROMMATIS, externista FAHAD AHMED, Jonathan E. SCHMITZ, Assaf RAZ, Holger BRUGGEMANN, Peter A. LAMBERT, Vincent A. FISCHETTI a Ondřej SLABÝ. Importance of Propionibacterium acnes hemolytic activity in human intervertebral discs: A microbiological study. Plos one. San Francisco: Public Library of Science, 2018, roč. 13, č. 11, s. 1-10. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0208144. |
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@article{1490117,
author = {Capoor, Manu and Růžička, Filip and Sandhu, Gurpreet and Rollason, Jess and Mavrommatis, Konstantinos and Fahad Ahmed, externista and Schmitz, Jonathan E. and Raz, Assaf and Bruggemann, Holger and Lambert, Peter A. and Fischetti, Vincent A. and Slabý, Ondřej},
article_location = {San Francisco},
article_number = {11},
doi = {http://dx.doi.org/10.1371/journal.pone.0208144},
keywords = {Propionibacterium acnes},
language = {eng},
issn = {1932-6203},
journal = {Plos one},
title = {Importance of Propionibacterium acnes hemolytic activity in human intervertebral discs: A microbiological study},
volume = {13},
year = {2018}
}
TY - JOUR
ID - 1490117
AU - Capoor, Manu - Růžička, Filip - Sandhu, Gurpreet - Rollason, Jess - Mavrommatis, Konstantinos - Fahad Ahmed, externista - Schmitz, Jonathan E. - Raz, Assaf - Bruggemann, Holger - Lambert, Peter A. - Fischetti, Vincent A. - Slabý, Ondřej
PY - 2018
TI - Importance of Propionibacterium acnes hemolytic activity in human intervertebral discs: A microbiological study
JF - Plos one
VL - 13
IS - 11
SP - 1-10
EP - 1-10
PB - Public Library of Science
SN - 19326203
KW - Propionibacterium acnes
N2 - Most patients with chronic lower back pain (CLBP) exhibit degenerative disc disease. Disc specimens obtained during initial therapeutic discectomies are often infected/colonized with Propionibacterium acnes, a Gram-positive commensal of the human skin. Although pain associated with infection is typically ascribed to the body's inflammatory response, the Gram-positive bacterium Staphylococcus aureus was recently observed to directly activate nociceptors by secreting pore-forming alpha-hemolysins that disrupt neuronal cell membranes. The hemolytic activity of P. acnes in cultured disc specimens obtained during routine therapeutic discectomies was assessed through incubation on sheep-blood agar. The beta-hemolysis pattern displayed by P. acnes on sheep-blood agar was variable and phylogroup-dependent. Their molecular phylogroups were correlated with their hemolytic patterns. Our findings raise the possibility that pore-forming proteins contribute to the pathogenesis and/or symptomology of chronic P. acnes disc infections and CLBP, at least in a subset of cases.
ER -
CAPOOR, Manu, Filip RŮŽIČKA, Gurpreet SANDHU, Jess ROLLASON, Konstantinos MAVROMMATIS, externista FAHAD AHMED, Jonathan E. SCHMITZ, Assaf RAZ, Holger BRUGGEMANN, Peter A. LAMBERT, Vincent A. FISCHETTI a Ondřej SLABÝ. Importance of Propionibacterium acnes hemolytic activity in human intervertebral discs: A microbiological study. \textit{Plos one}. San Francisco: Public Library of Science, 2018, roč.~13, č.~11, s.~1-10. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0208144.
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