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@article{1490195,
author = {Kushkevych, Ivan and Dordević, Dani and Vítězová, Monika},
article_location = {WARSAW},
article_number = {1},
doi = {http://dx.doi.org/10.1515/med-2019-0010},
keywords = {pH gut; Ulcerative colitis; Hydrogen sulfide; Toxicity; Sulfate-reducing bacteria},
language = {eng},
issn = {2391-5463},
journal = {Open Medicine formerly Central European Journal of Medicine},
title = {Analysis of pH dose-dependent growth of sulfate-reducing bacteria},
url = {https://www.degruyter.com/view/j/med.2019.14.issue-1/med-2019-0010/med-2019-0010.xml?format=INT&fbclid=IwAR0iUtqHhL0O0bRv8gOsr2afOk_7guS0gYguyr3DDTea1aZpS9AKCcGKMKk},
volume = {14},
year = {2019}
}
TY - JOUR
ID - 1490195
AU - Kushkevych, Ivan - Dordević, Dani - Vítězová, Monika
PY - 2019
TI - Analysis of pH dose-dependent growth of sulfate-reducing bacteria
JF - Open Medicine formerly Central European Journal of Medicine
VL - 14
IS - 1
SP - 66-74
EP - 66-74
PB - DE GRUYTER POLAND SP ZOO
SN - 23915463
KW - pH gut
KW - Ulcerative colitis
KW - Hydrogen sulfide
KW - Toxicity
KW - Sulfate-reducing bacteria
UR - https://www.degruyter.com/view/j/med.2019.14.issue-1/med-2019-0010/med-2019-0010.xml?format=INT&fbclid=IwAR0iUtqHhL0O0bRv8gOsr2afOk_7guS0gYguyr3DDTea1aZpS9AKCcGKMKk
L2 - https://www.degruyter.com/view/j/med.2019.14.issue-1/med-2019-0010/med-2019-0010.xml?format=INT&fbclid=IwAR0iUtqHhL0O0bRv8gOsr2afOk_7guS0gYguyr3DDTea1aZpS9AKCcGKMKk
N2 - Lower intraluminal colonic pH is an indication for the development of inflammatory bowel disease including active ulcerative colitis. Involvement of intestinal sulfate-reducing bacteria in decreasing bowel pH by the production of H2S and acetate as well as their sensitivity has never been reported before. The study of the relative pH and survival of Desulfovibrio piger Vib-7 by monitoring sulfate reduction parameters was the aim of this work. Monitoring was done through the measurement of bacterial growth (biomass), dissimilatory sulfate reduction parameters: sulfate consumption, lactate oxidation, hydrogen sulfide and acetate production. According to our results, we observed that lower pH (<5) significantly inhibited D. piger Vib-7 growth. This inhibition was also noticed when alkaline media (>9 pH) was used, though the reduction was not at the rate as in media with pH of 4. The research indicates that the growth of D. piger Vib-7 is inhibited at pH of 4 which is not as low as the pH found in people with severely developed inflammatory bowel diseases such as ulcerative colitis. Certainly the interaction (synergistic effect) between both hydrogen sulfide and acetate accumulation can also play an important etiological role in the development of bowel inflammation in humans and animals.
ER -
KUSHKEVYCH, Ivan, Dani DORDEVI$\backslash$'C a Monika VÍTĚZOVÁ. Analysis of pH dose-dependent growth of sulfate-reducing bacteria. \textit{Open Medicine formerly Central European Journal of Medicine}. WARSAW: DE GRUYTER POLAND SP ZOO, 2019, roč.~14, č.~1, s.~66-74. ISSN~2391-5463. Dostupné z: https://dx.doi.org/10.1515/med-2019-0010.
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