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@article{1490257,
author = {Kostolanská, Katarína and Peš, Ondřej and Zendulka, Ondřej and Máchal, Jan and Juřica, Jan},
article_number = {12},
doi = {http://dx.doi.org/10.1007/s11696-019-00682-4},
keywords = {Cytochrome P450; Phenotype; Lansoprazole; 5-Hydroxylansoprazole; Lansoprazole sulfone; Liquid chromatography; Mass spectrometry; Metabolites;},
language = {eng},
issn = {2585-7290},
journal = {Chemical Papers},
title = {Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping},
url = {https://link.springer.com/article/10.1007/s11696-019-00682-4#citeas},
volume = {73},
year = {2019}
}
TY - JOUR
ID - 1490257
AU - Kostolanská, Katarína - Peš, Ondřej - Zendulka, Ondřej - Máchal, Jan - Juřica, Jan
PY - 2019
TI - Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping
JF - Chemical Papers
VL - 73
IS - 12
SP - 2955-2963
EP - 2955-2963
PB - Slovenská akadémia vied
SN - 25857290
KW - Cytochrome P450
KW - Phenotype
KW - Lansoprazole
KW - 5-Hydroxylansoprazole
KW - Lansoprazole sulfone
KW - Liquid chromatography
KW - Mass spectrometry
KW - Metabolites;
UR - https://link.springer.com/article/10.1007/s11696-019-00682-4#citeas
L2 - https://link.springer.com/article/10.1007/s11696-019-00682-4#citeas
N2 - A simple and sensitive liquid chromatography method with absorbance or mass spectrometry detection was developed and validated for the determination of lansoprazole, lansoprazole sulfone, and 5-hydroxylansorpazole in human serum with omeprazole as an internal standard. Analytes were, after an extraction step with a mixture of isopropyl alcohol: dichloromethane (2:8, v/v), separated in a gradient elution (acetonitrile: 20 mM ammonium formate) and detected at 280 and 300 nm or by monitoring selective reactions in a triple quadrupole mass analyzer. The limits of detection were, for all analytes, below 2 ng/mL and 3 pg/mL in the LC UV and LC MS method, respectively. The combined linear dynamic range exceeded 5 orders of magnitude. The method was successfully applied in the assessment of CYP2C19 and CYP3A4 metabolic phenotypes in ST-elevated myocardial infarction patients receiving novel anticoagulant treatment.
ER -
KOSTOLANSKÁ, Katarína, Ondřej PEŠ, Ondřej ZENDULKA, Jan MÁCHAL and Jan JUŘICA. Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping. \textit{Chemical Papers}. Slovenská akadémia vied, 2019, vol.~73, No~12, p.~2955-2963. ISSN~2585-7290. Available from: https://dx.doi.org/10.1007/s11696-019-00682-4.
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